Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ingrid Gerner"'
Autor:
Ingrid Gerner, Etje Hulzebos
Publikováno v:
Regulatory Toxicology and Pharmacology. 58:131-144
The Integrated Assessment Scheme (IAS) defines weight factors for each piece of toxicological information under REACH in an Integrated Testing Strategy. This IAS is illustrated on skin irritation for Classification and Labelling (C&L) for five substa
Publikováno v:
Scopus-Elsevier
The notification procedure for new chemicals of the European Union (EU) requires protocols on physicochemical and toxicological tests for the evaluation of physico-chemical properties and probable toxic effects of each notified substance. In order to
Autor:
Dieter Traue, Ingrid Gerner, Manfred Liebsch, Helena Kandarova, Elisabeth Schmidt, Elke Genschow, Horst Spielmann
Publikováno v:
Alternatives to Laboratory Animals. 33:351-367
During the past decade, several validation studies have been conducted on in vitro methods for discriminating between skin irritating and non-irritating chemicals. The reconstructed human skin models, EpiDerm and EPISKIN, provided the most promising
Publikováno v:
QSAR & Combinatorial Science. 24:378-384
This paper describes the Skin Irritation Corrosion Rules Estimation Tool (SICRET) that was developed to allow others to estimate whether their chemicals are likely to cause skin irritation or skin corrosion. SICRET uses physicochemical property limit
Publikováno v:
QSAR & Combinatorial Science. 24:332-342
In this paper structural alerts for acute skin lesions were categorized as irritation or corrosion or a combination of corrosion/irritation alerts. Categorizing the alerts according to their mechanisms of skin irritation and corrosion and connecting
Publikováno v:
QSAR & Combinatorial Science. 23:721-725
This paper describes previously-developed (quantitative) structure-activity relationships [(Q)SARs]for predicting skin irritation and corrosion, proposes mechanisms of skin irritation and corrosion, and discusses the transparency and applicability of
Publikováno v:
Scopus-Elsevier
The new European Union (EU) chemicals policy, as described in the White Paper entitled Strategy for a Future Chemicals Policy, has identified a need for computer-based tools suitable for predicting the hazardous properties of chemicals. Two sets of s
Publikováno v:
QSAR & Combinatorial Science. 23:726-733
This is believed to be the first paper to promote the use of rules based on (quantitative) structure-activity relationship [(Q)SAR] models for identifying chemicals that are not likely to cause a specific adverse health effect, viz., skin irritation
Autor:
Klaus Wettig, Ingrid Gerner, Horst Spielmann, Richard Vogel, Agnes Schulte, Thomas Höfer, Ursula Gundert-Remy, Manfred Liebsch
Publikováno v:
Archives of Toxicology. 78:549-564
During the past 20 years the EU legislation for the notification of chemicals has focussed on new chemicals and at the same time failed to cover the evaluation of existing chemicals in Europe. Therefore, in a new EU chemicals policy (REACH, Registrat
Autor:
Ingrid Gerner, E. Schlede
Publikováno v:
Toxicology Letters. 127:169-175
The European legislation on control and evaluation of chemicals requires hazard and risk assessment of chemicals for human health and the environment. Technical guidance on carrying out this assessment includes the use of information based on results