Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Ingrid E. Wertz"'
Autor:
Christopher W. Davies, Simon E. Vidal, Lilian Phu, Jawahar Sudhamsu, Trent B. Hinkle, Scott Chan Rosenberg, Frances-Rose Schumacher, Yi Jimmy Zeng, Carsten Schwerdtfeger, Andrew S. Peterson, Jennie R. Lill, Christopher M. Rose, Andrey S. Shaw, Ingrid E. Wertz, Donald S. Kirkpatrick, James T. Koerber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
UBE2W catalyzes the ubiquitination of protein N-termini but its substrate spectrum is largely unknown. Here, the authors discover mAbs selective for peptides derived from N-terminally ubiquitinated proteins, solve the structure of a peptide-bound mAb
Externí odkaz:
https://doaj.org/article/cbfb2674260f4b51a1c495c83e07dcb5
Autor:
David S. Hewings, Johanna Heideker, Taylur P. Ma, Andrew P. AhYoung, Farid El Oualid, Alessia Amore, Gregory T. Costakes, Daniel Kirchhofer, Bradley Brasher, Thomas Pillow, Nataliya Popovych, Till Maurer, Carsten Schwerdtfeger, William F. Forrest, Kebing Yu, John Flygare, Matthew Bogyo, Ingrid E. Wertz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Deubiquitinases are proteases that cleave after the C-terminus of ubiquitin to hydrolyze ubiquitin chains and cleave ubiquitin from substrates. Here the authors describe a reactive-site-centric chemoproteomics approach to studying deubiquitinase acti
Externí odkaz:
https://doaj.org/article/a36fd9ead45149f0b851c7d214b80597
Autor:
Charlene Bashore, Sumit Prakash, Matthew C. Johnson, Ryan J. Conrad, Ivy A. Kekessie, Suzie J. Scales, Noriko Ishisoko, Tracy Kleinheinz, Peter S. Liu, Nataliya Popovych, Aaron T. Wecksler, Lijuan Zhou, Christine Tam, Inna Zilberleyb, Rajini Srinivasan, Robert A. Blake, Aimin Song, Steven T. Staben, Yingnan Zhang, David Arnott, Wayne J. Fairbrother, Scott A. Foster, Ingrid E. Wertz, Claudio Ciferri, Erin C. Dueber
Publikováno v:
Nature Chemical Biology. 19:55-63
Engineered destruction of target proteins by recruitment to the cell’s degradation machinery has emerged as a promising strategy in drug discovery. The majority of molecules that facilitate targeted degradation do so via a select number of ubiquiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cffe718a8e978d9932a3400ef0703fa
https://doi.org/10.1038/s41589-022-01218-w
https://doi.org/10.1038/s41589-022-01218-w
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/d1935c5b03e6433ea06acf491e7dc6f2
Autor:
Si-Han Chen, Sumit Prakash, Elizabeth Helgason, Caroline L. Gilchrist, Lillian R. Kenner, Rajini Srinivasan, Tim Sterne-Weiler, Marc Hafner, Robert Piskol, Erin C. Dueber, Habib Hamidi, Nicholas Endres, Xin Ye, Wayne J. Fairbrother, Ingrid E. Wertz
Modulation of proteolysis is an emerging therapeutic mainstay. The clinical success of thalidomide and analogs has inspired development of rationally-designed therapeutics that repurpose endogenous degradation machinery to target pathogenic proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::263fcd1748657baa60bcc9f96316c6b2
https://doi.org/10.1101/2023.02.06.527237
https://doi.org/10.1101/2023.02.06.527237
Autor:
Wayne J. Fairbrother, Sayumi Yamazoe, Ingrid E. Wertz, Nicole Blaquiere, Steven T. Staben, Willem den Besten, Domagoj Vucic, Kebing Yu, Melinda M. Mulvihill, Elizabeth Helgason, Erin C. Dueber, Kshitij Verma, Wilson Phung, Tatiana Goncharov, Sumit Prakash, Anita Izrael-Tomasevic
Publikováno v:
Journal of the American Chemical Society. 143:10571-10575
We hypothesized that the proximity-driven ubiquitylation of E3-interacting small molecules could affect the degradation of E3 ubiquitin ligases. A series of XIAP BIR2 domain-binding small molecules was modified to append a nucleophilic primary amine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f843d2ea05f107972c8984483e27ea
https://doi.org/10.1021/jacs.1c05269
https://doi.org/10.1021/jacs.1c05269
Autor:
Edmond R. Watson, Scott J. Novick, Mary E. Matyskiela, Philip P. Chamberlain, Andres Hernandez de la Peña, Jin-Yi Zhu, Eileen Tran, Patrick R. Griffin, Ingrid E. Wertz, Gabriel C. Lander
Cereblon (CRBN) is an ubiquitin ligase (E3) adaptor protein co-opted by CRBN E3 Ligase Modulatory Drugs (CELMoD) agents that target therapeutically-relevant proteins for degradation. Prior crystallographic studies defined the drug-binding site within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6725d3acc0caf347d97d1c4f855d6401
https://doi.org/10.1101/2022.07.02.498551
https://doi.org/10.1101/2022.07.02.498551
Autor:
Ingrid E Wertz, Alessio Ciulli
Publikováno v:
Current Opinion in Chemical Biology. 62:A1-A3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca2b91d2908ccc26d282126761c28b9
https://doi.org/10.1016/j.cbpa.2021.04.010
https://doi.org/10.1016/j.cbpa.2021.04.010
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Publikováno v:
eLife, Vol 5 (2016)
ER-targeted therapeutics provide valuable treatment options for patients with ER+ breast cancer, however, current relapse and mortality rates emphasize the need for improved therapeutic strategies. The recent discovery of prevalent ESR1 mutations in
Externí odkaz:
https://doaj.org/article/e0d8a246d19143f9bd877f0b6caa0659
Autor:
Jennifer Cable, Eilika Weber‐Ban, Tim Clausen, Kylie J. Walters, Michal Sharon, Daniel J. Finley, Yangnan Gu, John Hanna, Yue Feng, Sascha Martens, Anne Simonsen, Malene Hansen, Hong Zhang, Jonathan M. Goodwin, Alessio Reggio, Chunmei Chang, Liang Ge, Brenda A. Schulman, Raymond J. Deshaies, Ivan Dikic, J. Wade Harper, Ingrid E. Wertz, Nicolas H. Thomä, Mikołaj Słabicki, Judith Frydman, Ursula Jakob, Della C. David, Eric J. Bennett, Carolyn R. Bertozzi, Richa Sardana, Vinay V. Eapen, Serena Carra
Publikováno v:
Annals of the New York Academy of Sciences 1510(1), 79-99 (2022). doi:10.1111/nyas.14745
Targeted protein degradation is critical for proper cellular function and development. Protein degradation pathways, such as the ubiquitin proteasomes system, autophagy, and endosome-lysosome pathway, must be tightly regulated to ensure proper elimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88110e83b56645cb723743deb2706a33