Tristetraprolin expression by keratinocytes protects against skin carcinogenesis

Autor: Assiya Assabban, Ingrid Dubois-Vedrenne, Laurye Van Maele, Rosalba Salcedo, Brittany L. Snyder, Lecong Zhou, Abdulkader Azouz, Bérengère de Toeuf, Gaëlle Lapouge, Caroline La, Maxime Melchior, Muriel Nguyen, Séverine Thomas, Si Fan Wu, Wenqian Hu, Véronique Kruys, Cédric Blanpain, Giorgio Trinchieri, Cyril Gueydan, Perry J. Blackshear, Stanislas Goriely

Publikováno v: JCI Insight, Vol 6, Iss 5 (2021)

Cancer is caused primarily by genomic alterations resulting in deregulation of gene regulatory circuits in key growth, apoptosis, or DNA repair pathways. Multiple genes associated with the initiation and development of tumors are also regulated at th

Externí odkaz: https://doaj.org/article/5f7e68b7fa75438a96e412ef4ca0c6e9

Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis

Autor: Ingrid Dubois-Vedrenne, Olivier De Henau, Virginie Robert, Francina Langa, Joaquim Javary, Diana Al Delbany, Olivier Vosters, Edgar Angelats-Canals, Maxime Vernimmen, Souphalone Luangsay, Valérie Wittamer, Marc Parmentier

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Chemerin is a multifunctional protein acting mainly through the G protein-coupled receptor ChemR23/CMKLR1/Chemerin1. Its expression is frequently downregulated in human tumors, including in melanoma and squamous cell carcinoma of the skin and anti-tu

Externí odkaz: https://doaj.org/article/d7ef417c3af24815916815e94ed14885

The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis

Autor: Diana Al Delbany, Anne Lefort, Virginie Robert, Marc Parmentier, Francina Langa, Maxime Vernimmen, Valérie Wittamer, Ingrid Dubois-Vedrenne, Olivier De Henau, Frédérick Libert

Publikováno v: Oncotarget
Oncotarget, 12 (19
Oncotarget, 2021, 12 (19), pp.1903-1919. ⟨10.18632/oncotarget.28056⟩

International audience; Chemerin, a multifunctional protein acting through the receptor ChemR23/CMKLR1, is downregulated in various human tumors and was shown to display antitumoral properties in mouse models of cancer. In the present study, we repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b167137d86f0349e45569aead05af60e
https://pubmed.ncbi.nlm.nih.gov/34548907

Internalization and desensitization of the human glucose-dependent-insulinotropic receptor is affected by N-terminal acetylation of the agonist

Autor: Pascal Clerc, Daniel Fourmy, Remi Magnan, Ingrid Dubois-Vedrenne, Véronique Gigoux, Marie-Julie Gherardi, Claire Sanchez, Marie Laval, Irina G. Tikhonova, Sadek Ismail, Romina D'Angelo

Publikováno v: Ismail, S, Dubois-Vedrenne, I, Laval, M, Tikhonova, I G, D'Angelo, R, Sanchez, C, Clerc, P, Gherardi, M-J, Gigoux, V, Magnan, R & Fourmy, D 2015, ' Internalization and desensitization of the human glucose-dependent-insulinotropic receptor is affected by N-terminal acetylation of the agonist ', Molecular and Cellular Endocrinology, vol. 414, pp. 202-215 . https://doi.org/10.1016/j.mce.2015.07.001

How incretins regulate presence of their receptors at the cell surface and their activity is of paramount importance for the development of therapeutic strategies targeting these receptors. We have studied internalization of the human Glucose-Insulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96623244a4a20b32c7d2995765f00c58
https://pubmed.ncbi.nlm.nih.gov/26225752