Zobrazeno 1 - 10 of 42 pro vyhledávání: '"Ingrid Dreveny"'
1
Akademický článek
Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
Autor: Maria Pilar Sanchez-Bailon, Soo-Youn Choi, Elizabeth R. Dufficy, Karan Sharma, Gavin S. McNee, Emma Gunnell, Kelly Chiang, Debashish Sahay, Sarah Maslen, Grant S. Stewart, J. Mark Skehel, Ingrid Dreveny, Clare C. Davies
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Post-translational modifications are critical for regulating the DNA damage response. Here, the authors identify a methylation-deubiquitination crosstalk between methyltransferase PRMT1 and deubiquitinase USP11, showing that the enzymes regulate each
Externí odkaz: https://doaj.org/article/ea281da007d54673887d7d80ba9fed3c
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2
Akademický článek
Enhancing PLP-Binding Capacity of Class-III ω-Transaminase by Single Residue Substitution
Autor: David Roura Padrosa, Raphael Alaux, Phillip Smith, Ingrid Dreveny, Fernando López-Gallego, Francesca Paradisi
Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Transaminases are pyridoxal-5′-phosphate (PLP) binding enzymes, broadly studied for their potential industrial application. Their affinity for PLP has been related to their performance and operational stability and while significant differences in
Externí odkaz: https://doaj.org/article/5ca64782311c4f379926d1612053137f
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6
Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases
Autor: Anastasios, Spiliotopoulos, Sigrun K, Maurer, Maria T, Tsoumpeli, Juan A F, Bonfante, Jonathan P, Owen, Kevin C, Gough, Ingrid, Dreveny
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2591
Phage display (PD) is a powerful method and has been extensively used to generate monoclonal antibodies and identify epitopes, mimotopes, and protein interactions. More recently, the combination of next-generation sequencing (NGS) with PD (NGPD) has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e003b3f0a17b16e88204a493f089ee8
https://pubmed.ncbi.nlm.nih.gov/36350550
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7
Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)
Autor: Emma A. Gunnell, Alaa Al-Noori, Usama Muhsen, Clare C. Davies, James Dowden, Ingrid Dreveny
Publikováno v: 'Biochemical Journal ', vol: 477, pages: 787-800 (2020)
Biochemical Journal
Attenuating the function of protein arginine methyltransferases (PRMTs) is an objective for the investigation and treatment of several diseases including cardiovascular disease and cancer. Bisubstrate inhibitors that simultaneously target binding sit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac78efc3e21d2982fcd15f6eed580f7
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:56173
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8
Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
Autor: Elizabeth R. Dufficy, Karan Sharma, Maria Pilar Sanchez-Bailon, Grant S. Stewart, Kelly Chiang, Sarah L. Maslen, Soo-Youn Choi, Emma A. Gunnell, Clare C. Davies, Debashish Sahay, Ingrid Dreveny, Gavin S. McNee, J. Mark Skehel
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Cross-talk between distinct protein post-translational modifications is critical for an effective DNA damage response. Arginine methylation plays an important role in maintaining genome stability, but how this modification integrates with other enzym
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be0c226075a1ed2bb9cfe81e979b0a9
https://nottingham-repository.worktribe.com/file/6681867/1/S41467-021-26413-6
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9
Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI
Autor: Ingrid Dreveny, Chan Li, Keith R. McCrae, Jonas Emsley, Kayleigh M. Voos, Renhao Li, Monika Pathak, Gareth Hall
Publikováno v: Journal of Thrombosis and Haemostasis
'Journal of Thrombosis and Haemostasis ', vol: 17, pages: 759-770 (2019)
Essentials Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII contributing to bradykinin generation. Monomeric PKa and dimeric homologue FXI utilize the N-terminal apple domains to recruit substrates. A high-resolution 1.3 Å st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c0c038bd4f3d7a5a51f6eb1ff6680c
https://doi.org/10.1111/jth.14418
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10
Exosites expedite blood coagulation
Autor: Ingrid Dreveny, Maria Luiza Vilela Oliva, Jonas Emsley
Publikováno v: J Biol Chem
Factor X activation by the intrinsic Xase complex, composed of factor IXa bound to factor VIIIa on membranes, is essential for the amplified blood coagulation response. The biological significance of this step is evident from bleeding arising from de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a635753a9d6faea705d6dd4d822158f
https://pubmed.ncbi.nlm.nih.gov/32859749
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