Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ingrid Caras"'
Autor:
Weihua Song, Daniel E. H. Afar, Peter Burger, Yu-Tzu Tai, Hervé Avet-Loiseau, Wanling Xie, Paul G. Richardson, Claire Mathiot, Audie G. Rice, Anne van Abbema, Xian Feng Li, Kenneth C. Anderson, Lynne Jesaitis, Edie Weller, Ingrid Caras, Alfred Ian Lee, Klaus Podar, Teru Hideshima, Nikhil C. Munshi, Myles B.C. Dillon, Merav Leiba, Debbie A. Law
Publikováno v:
Blood. 112:1329-1337
Currently, no approved monoclonal antibody (mAb) therapies exist for human multiple myeloma (MM). Here we characterized cell surface CS1 as a novel MM antigen and further investigated the potential therapeutic utility of HuLuc63, a humanized anti-CS1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f1999048162480a9413aa270f7095b
https://doi.org/10.1182/blood-2007-08-107292
https://doi.org/10.1182/blood-2007-08-107292
Publikováno v:
Journal of Immunological Methods. 315:80-87
Confirmatory assays for immunogenicity testing typically involve testing a sample in the presence or absence of excess drug. A decrease in assay signal in the presence of drug is taken to indicate the presence of anti-drug antibodies (ADAb) and the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03674e2f692d85856fc87a89c1f99aed
https://doi.org/10.1016/j.jim.2006.07.010
https://doi.org/10.1016/j.jim.2006.07.010
Autor:
Steven D. Shapiro, Richard Murray, Harold A. Chapman, Stephen J. Weiss, Sergey Filippov, Lynn M. Matrisian, Ingrid Caras
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 198, iss 6
The Journal of experimental medicine, vol 198, iss 6
Human macrophages found in juxtaposition to fragmented elastin in vivo express the elastolytic matrix metalloproteinases (MMPs) progelatinase B, prometalloelastase, and promatrilysin. Though MMPs can degrade a range of extracellular matrix components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df5b6934485fa4990457974b76d1263
http://europepmc.org/articles/PMC2194197
http://europepmc.org/articles/PMC2194197
Publikováno v:
Cytotechnology. 35:189-196
Genomics-based approaches are increasingly being used to identify disease-associated genes that represent potential new drug targets. As a first step in the validation of genes of unknown function, we describe a method for rapidly determining the sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6912a810ef5f42d8e8ccf5b6fead2e30
https://doi.org/10.1023/a:1013152432069
https://doi.org/10.1023/a:1013152432069
Autor:
Antonello Punturieri, Richard Murray, Edward D. Allen, Stephen J. Weiss, Ingrid Caras, Vivek Y. Reddy, Sergey Filippov
Publikováno v:
The Journal of Experimental Medicine
Human macrophages mediate the dissolution of elastic lamina by mobilizing tissue-destructive cysteine proteinases. While macrophage-mediated elastin degradation has been linked to the expression of cathepsins L and S, these cells also express catheps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae1d8c7fd00133b87f463cddfd3a7b5
https://doi.org/10.1084/jem.192.6.789
https://doi.org/10.1084/jem.192.6.789
Autor:
Vanitha, Ramakrishnan, Vinay, Bhaskar, Debbie A, Law, Melanie H L, Wong, Robert B, DuBridge, Danna, Breinberg, Christopher, O'Hara, David B, Powers, Gao, Liu, Jennifer, Grove, Peter, Hevezi, Kellie M, Cass, Susan, Watson, Ferdinand, Evangelista, Rick A, Powers, Barbara, Finck, Margaret, Wills, Ingrid, Caras, Yuni, Fang, Donald, McDonald, Dale, Johnson, Richard, Murray, Ursula, Jeffry
Publikováno v:
Journal of experimental therapeuticsoncology. 5(4)
Integrin alpha5beta1, the principal fibronectin receptor, is an important survival factor, playing a key role in angiogenesis. Angiogenesis is critical for tumor growth, and anti-angiogenic therapies have met clinical success. To validate the therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c146b31c46a86d3a5bc222268237d22
https://pubmed.ncbi.nlm.nih.gov/17024968
https://pubmed.ncbi.nlm.nih.gov/17024968
Autor:
Gordon F. O'Neill, Susan M. Henshall, Kurt C. Gish, David Golovsky, David I. Quinn, Melanie Wong, James G. Kench, Phillip Brenner, Jennifer Turner, Warick Delprado, John J. Grygiel, Raji Kooner, David H. Mack, Daniel E. H. Afar, Robert L. Sutherland, Phillip D. Stricker, Ingrid Caras, Lisa G. Horvath, C-Soon Lee, Ursula Jeffry, Vanitha Ramakrishnan, K. Rasiah
Publikováno v:
Oncogene. 22(38)
We have utilized oligonucleotide microarrays to identify novel genes of potential clinical and biological importance in prostate cancer. RNA from 74 prostate cancers and 164 normal body samples representing 40 different tissues were analysed using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa8cf691596a3e65dfb149320de44b7
https://pubmed.ncbi.nlm.nih.gov/12955079
https://pubmed.ncbi.nlm.nih.gov/12955079
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991). 9(6)
The development of axonal connections between thalamic nuclei and their cortical target areas occurs in a highly specific manner. To explore the mechanisms of thalamocortical axon pathfinding, we investigated the expression of several members of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d002261d25b86182bc9e0e27ffd4636
https://pubmed.ncbi.nlm.nih.gov/10498278
https://pubmed.ncbi.nlm.nih.gov/10498278
Autor:
William Bensinger, Ann Mohrbacher, Anil Singhal, Nikhil C. Munshi, Jeffrey A. Zonder, Seema Singhal, Mohamad A. Hussein, Frits van Rhee, Ingrid Caras
Publikováno v:
Blood. 112:2773-2773
Elotuzumab is a humanized monoclonal antibody directed against CS1, a cell surface glycoprotein, which is highly and uniformly expressed in multiple myeloma. Elotuzumab has demonstrated significant anti-tumor activity in pre-clinical mouse models of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9c2db1f2c759aac44a3f74aa213acd8
https://doi.org/10.1182/blood.v112.11.2773.2773
https://doi.org/10.1182/blood.v112.11.2773.2773
Autor:
Jordan Hiller, Ingrid Caras, Zhanna Kobalava, Markus Meyer, Wolf-Georg Forssmann, Veselin Mitrovic, Petar M. Seferović, Jadine Moy, Hartmut Lüss
Publikováno v:
Journal of Cardiac Failure. 13:S136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8040b5c61fec009f1b56527601858418
https://doi.org/10.1016/j.cardfail.2007.06.523
https://doi.org/10.1016/j.cardfail.2007.06.523