Výsledky vyhledávání - "Ingrid C. Dunlop"

Plasma pharmacokinetics of N -[2-(dimethylamino)ethyl]acridine-4-carboxamide in a phase I trial

Autor: James W. Paxton, Philip Kestell, Michael R. McCrystal, Bruce C. Baguley, Ranjith S.K.A. Gamage, Barrie D. Evans, Ingrid C. Dunlop

Publikováno v: Cancer Chemotherapy and Pharmacology. 44:45-50

DACA [N-[2-(dimethylamino)ethyl]acridine-4-carboxamide] is an acridine derivative with high activity against solid tumours in mice and a dual mode of cytotoxic action involving topoisomerases I and II. The plasma pharmacokinetics of DACA were studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3cf6a43c59fffd82205903788e1636
https://doi.org/10.1007/s002800050943

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Plasma disposition, metabolism and excretion of the experimental antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the mouse, rat and rabbit

Autor: James W. Paxton, Philip Kestell, Gordon W. Rewcastle, Bruce C. Baguley, Ingrid C. Dunlop

Publikováno v: Cancer chemotherapy and pharmacology. 43(4)

5,6-Dimethylxanthenone-4-acetic acid (DMXAA), an experimental antitumour agent currently undergoing phase I clinical trial, has a maximum tolerated dose (MTD) in male BDF1 mice of 99 micromol/kg. We have found the male Sprague-Dawley rat and the New

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d8d259f4be454838a3e89750434008
https://pubmed.ncbi.nlm.nih.gov/10071984

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