Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ingrid C Rulifson"'
Autor:
Jiamiao Lu, Jasper Lee, Eric Yuan, Devin L. Wakefield, Matt Kanke, Danielle Pruitt, Jose Barreda, Ingrid C. Rulifson, Jiansong Xie, John Ferbas, Jason Long, Bryan Meade, Oliver Homann, Wei Guo, Tina Gomes, Hong Zhou, Bin Wu, Jixin Cui, Songli Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102335- (2024)
Small interfering RNAs (siRNAs) hold considerable therapeutic potential to selectively silence previously “undruggable” disease-associated targets, offering new opportunities to fight human diseases. This therapeutic strategy, however, is limited
Externí odkaz:
https://doaj.org/article/65bae3facf284c1b8c31c8c6325702c1
Autor:
Ingrid C Rulifson, Ping Cao, Li Miao, David Kopecky, Linda Huang, Ryan D White, Kim Samayoa, Jonitha Gardner, Xiaosu Wu, Kui Chen, Trace Tsuruda, Oliver Homann, Helene Baribault, Harvey Yamane, Tim Carlson, Jed Wiltzius, Yang Li
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147254 (2016)
Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis. IA
Externí odkaz:
https://doaj.org/article/cc92adda697c42418dff19e2c29370d8
Autor:
Lei Liu, Jason Long, Ingrid C. Rulifson, Brad Herberich, Miki Hardy, Oliver Homann, Monica Florio, Mei-Chu Lo, Jerry Ryan Holder, Shivani Singh, Hui Dou, Michael Ollmann, Elissa Swearingen, Danielle Pruitt, Kelvin K. C. Sham, Bin Wu, Justin K. Murray, Artem Shkumatov
Publikováno v:
Nucleic Acid Therapeutics. 31:324-340
Human genome wide association studies confirm the association of the rs738409 single nucleotide polymorphism (SNP) in the gene encoding protein patatin like phospholipase domain containing 3 (PNPLA...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2000bde8307608b78ff279a1e4c61b
https://doi.org/10.1089/nat.2021.0026
https://doi.org/10.1089/nat.2021.0026
Autor:
Zhen Jiang, Selma Z. Elsarrag, Qiming Duan, Edward L. LaGory, Zhe Wang, Michael Alexanian, Sarah McMahon, Ingrid C. Rulifson, Sarah Winchester, Yi Wang, Christian Vaisse, Jonathan D. Brown, Mattia Quattrocelli, Charles Y. Lin, Saptarsi M. Haldar
Publikováno v:
Science Advances. 8
Circulating corticosteroids orchestrate stress adaptation, including inhibition of inflammation. While pathways governing corticosteroid biosynthesis and intracellular signaling are well understood, less is known about mechanisms controlling plasma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ad248dc083391cd4db6eab4d3d5dcd
https://doi.org/10.1126/sciadv.abj2917
https://doi.org/10.1126/sciadv.abj2917
Autor:
Ingrid C. Rulifson, Mike Ollmann, Cynthia Cam, Ki Jeong Lee, William G. Richards, Dana Nojima, Yang Li, Li Miao, Miki Hardy, Kelly Hensley, Jamila Gupte, Kim Samayoa, Patrick J. Collins, James B. Rottman
The discovery of brown adipose tissue (BAT) as a key regulator of energy expenditure has sparked interest in identifying novel soluble factors capable of activating inducible BAT (iBAT) to combat obesity. Using a high content cell-based screen, we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204eb2aa28f822243f97bf54af65befd
https://europepmc.org/articles/PMC5290965/
https://europepmc.org/articles/PMC5290965/
Autor:
Derk ten Berge, Makoto Mark Taketo, Hainan Chen, Matthias Hebrok, Patrick W. Heiser, Seung K. Kim, Xueying Gu, Roel Nusse, Satyajit K. Karnik, Ingrid C. Rulifson
Publikováno v:
Proceedings of the National Academy of Sciences. 104:6247-6252
There is widespread interest in defining factors and mechanisms that stimulate proliferation of pancreatic islet cells. Wnt signaling is an important regulator of organ growth and cell fates, and genes encoding Wnt-signaling factors are expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ccf2b85d5739c8e2ac9cd3d97eb31e
https://doi.org/10.1073/pnas.0701509104
https://doi.org/10.1073/pnas.0701509104
Autor:
Yang Li, Li Miao, Kim Samayoa, Ingrid C. Rulifson, Ryan White, Helene Baribault, Harvey Yamane, David J. Kopecky, Xiaosu Wu, Jed Wiltzius, Trace Tsuruda, Linda Huang, Oliver Homann, Kui Chen, Ping Cao, Tim Carlson, Jonitha Gardner
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 2, p e0147254 (2016)
PLoS ONE, Vol 11, Iss 2, p e0147254 (2016)
Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis. IA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c93bca9bb70a622325bbe8a89146b5
https://pubmed.ncbi.nlm.nih.gov/26840340
https://pubmed.ncbi.nlm.nih.gov/26840340
Autor:
Ingrid C. Rulifson, Yuichi Hori, Jeremy J Heit, Seung K. Kim, Bernette C. Tsai, John D. Cahoy
Publikováno v:
Proceedings of the National Academy of Sciences. 99:16105-16110
The use of embryonic stem cells for cell-replacement therapy in diseases like diabetes mellitus requires methods to control the development of multipotent cells. We report that treatment of mouse embryonic stem cells with inhibitors of phosphoinositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7ad45bfe834c7ac8bddbf63ccced97
https://doi.org/10.1073/pnas.252618999
https://doi.org/10.1073/pnas.252618999
Publikováno v:
American Journal of Transplantation. 2:510-519
Both the direct and indirect antigen presentation pathways are important mechanisms for T cell-mediated allograft rejection. Studies using knockout mice and monoclonal antibodies have demonstrated that CD4+ T cells are both necessary and sufficient f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80fa6dc53d88e2c50d59245bdc76c60
https://doi.org/10.1034/j.1600-6143.2002.20604.x
https://doi.org/10.1034/j.1600-6143.2002.20604.x
Autor:
William G. Richards, Ingrid C. Rulifson, Jamila Gupte, Ki Jeong Lee, Jonitha Gardner, Xinle Wu, Bryan Lemon, Jun Zhang, Helene Baribault, Zheng Pan, Yang Li, Hongfei Ge, Suzanne Coberly, Yan Gong
Publikováno v:
EBioMedicine
EBioMedicine, Vol 2, Iss 3, Pp 214-224 (2015)
EBioMedicine, Vol 2, Iss 3, Pp 214-224 (2015)
The polarization of tissue resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to positively impact obesity and insulin resistance. Here we show that the soluble form of the extracellular domain (ECD) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c048f731e7fc51f983495da5fe686ca6
https://pubmed.ncbi.nlm.nih.gov/26151067
https://pubmed.ncbi.nlm.nih.gov/26151067