Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Ingrid Boekhoff"'
Autor:
Barbara Spix, Elisabeth S. Butz, Cheng-Chang Chen, Anna Scotto Rosato, Rachel Tang, Aicha Jeridi, Veronika Kudrina, Eva Plesch, Philipp Wartenberg, Elisabeth Arlt, Daria Briukhovetska, Meshal Ansari, Gizem Günes Günsel, Thomas M. Conlon, Amanda Wyatt, Sandra Wetzel, Daniel Teupser, Lesca M. Holdt, Fabien Ectors, Ingrid Boekhoff, Ulrich Boehm, Jaime García-Añoveros, Paul Saftig, Martin Giera, Sebastian Kobold, Herbert B. Schiller, Susanna Zierler, Thomas Gudermann, Christian Wahl-Schott, Franz Bracher, Ali Önder Yildirim, Martin Biel, Christian Grimm
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the l
Externí odkaz:
https://doaj.org/article/7d029bd581f74fcaa96bcacc1faef5b8
Autor:
Wiebke Nadolni, Roland Immler, Kilian Hoelting, Marco Fraticelli, Myriam Ripphahn, Simone Rothmiller, Masayuki Matsushita, Ingrid Boekhoff, Thomas Gudermann, Markus Sperandio, Susanna Zierler
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
During inflammation, neutrophils are one of the first responding cells of innate immunity, contributing to a fast clearance of infection and return to homeostasis. However, excessive neutrophil infiltration accelerates unsolicited disproportionate in
Externí odkaz:
https://doaj.org/article/7c8ee04e5a11479d9b310f0f5b376134
Publikováno v:
Cells, Vol 11, Iss 9, p 1465 (2022)
Two-pore channels (TPCs) are ligand-gated cation-selective ion channels that are preserved in plant and animal cells. In the latter, TPCs are located in membranes of acidic organelles, such as endosomes, lysosomes, and endolysosomes. Here, we focus o
Externí odkaz:
https://doaj.org/article/427d966c0021464a8c568bd4c22aa8ca
Autor:
Nele Zitranski, Heike Borth, Frauke Ackermann, Dorke Meyer, Laura Vieweg, Andreas Breit, Thomas Gudermann, Ingrid Boekhoff
Publikováno v:
Communicative & Integrative Biology, Vol 3, Iss 6, Pp 513-521 (2010)
Mammalian spermatozoa are highly polarized cells composed of two morphological and functional compartments, each optimized for a special task. Although the compartmentalization into head and tail may as such represent the anatomical basis to avoid ra
Externí odkaz:
https://doaj.org/article/ae5d520f1527421a97643f9c12545e8c
Publikováno v:
Pharmaceuticals, Vol 11, Iss 4, p 90 (2018)
Transient receptor potential (TRP) channels represent a large family of cation channels and many members of the TRP family have been shown to act as polymodal receptor molecules for irritative or potentially harmful substances. These chemosensory TRP
Externí odkaz:
https://doaj.org/article/9109868266ca4e6aba6edfbdfc65c86a
Autor:
Hans Jürgen Solinski, Franziska Petermann, Kathrin Rothe, Ingrid Boekhoff, Thomas Gudermann, Andreas Breit
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58756 (2013)
Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activ
Externí odkaz:
https://doaj.org/article/9c14ef663beb4416a56d4061dea2e544
Autor:
Dorke Meyer, Anja Voigt, Patricia Widmayer, Heike Borth, Sandra Huebner, Andreas Breit, Susan Marschall, Martin Hrabé de Angelis, Ulrich Boehm, Wolfgang Meyerhof, Thomas Gudermann, Ingrid Boekhoff
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32354 (2012)
BackgroundDuring their transit through the female genital tract, sperm have to recognize and discriminate numerous chemical compounds. However, our current knowledge of the molecular identity of appropriate chemosensory receptor proteins in sperm is
Externí odkaz:
https://doaj.org/article/fb4ac851ee8d40d4a02f591f1fcab6f0
Autor:
Birgit Hoeger, Wiebke Nadolni, Sarah Hampe, Kilian Hoelting, Marco Fraticelli, Nadja Zaborsky, Anna Madlmayr, Viktoria Sperrer, Laura Fraticelli, Lynda Addington, Dirk Steinritz, Vladimir Chubanov, Roland Geisberger, Richard Greil, Andreas Breit, Ingrid Boekhoff, Thomas Gudermann, Susanna Zierler
Cyclooxygenase-2 (COX-2) is a key regulator of inflammation. High constitutive COX-2 expression enhances survival and proliferation of tumor cells, whereas it adversely impacts anti-tumor immunity. We recently identified the melastatin-like transient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8374d52eaed27635ab2c7d59a5de35ff
https://doi.org/10.21203/rs.3.rs-2405917/v1
https://doi.org/10.21203/rs.3.rs-2405917/v1
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783031315220
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3513e7d3b92d7e8dba5cd5d4ac115d72
https://doi.org/10.1007/164_2022_634
https://doi.org/10.1007/164_2022_634
Publikováno v:
Molecular Pharmacology. 100:203-216
Norepinephrine (NE) controls many vital body functions by activating adrenergic receptors (AR). Average core body temperature (CBT) in mice is 37 {degree sign}C. Of note, CBT fluctuates between 36 and 38 {degree sign}C within 24 h, but little is know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e859f67ce813520b6d7acfae52435c2c
https://doi.org/10.1124/molpharm.121.000309
https://doi.org/10.1124/molpharm.121.000309