Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Ingrid, Granelli"'
1
A Bioanalytical Method for Quantification of Thioredoxins in Bacillus anthracis by Digestion with Immobilized Pepsin and LC–MS/MS and On-line LC/LC–MS/MS
Autor: Aljona Saleh, Tomas N. Gustafsson, Per-Olof Edlund, Britt-Marie Sjöberg, Ingrid Granelli, Margareta Sahlin
Publikováno v: Chromatographia. 79:383-393
We describe a method for the quantification of proteins in a biological matrix through digestion with pepsin. Pepsin is a gastric protease that efficiently cleaves proteins in an acidic environment ...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d723f4a6045b3ede9b403dc4923854b1
https://doi.org/10.1007/s10337-016-3048-6
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2
Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma
Autor: Thomas Helleday, Camilla Göktürk, Ulrika Warpman-Berglund, Ingrid Granelli, Aljona Saleh
Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 104:1-11
MTH1 is a protein that is required for cancer cell survival and is overexpressed in cancer cells. TH588 and TH287 are two new compounds that inhibit the MTH1 protein. The inhibitors were tested in pharmacokinetic studies on mice. A bioanalytical meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35874f0c7843fbcfd11fc36c37420c2f
https://doi.org/10.1016/j.jpba.2014.11.009
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4
Digestion of Enolase and Carbonic Anhydrase as Model Proteins for Therapeutic Proteins in Blood Plasma with Immobilized Thermolysin and Quantification of Some of the Peptides by LC/LC–MS/MS
Autor: Per-Olof Edlund, Ingrid Granelli, Aljona Saleh, Oscar Bruno
Publikováno v: Chromatographia. 77:59-74
There is a need for fast method development in the early drug discovery phase of therapeutic proteins. Thermolysin has not been used for quantification of proteins in blood plasma earlier. It is a thermostable protease which permits the use of high t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85a0b41233de30954bd221d312fdcb51
https://doi.org/10.1007/s10337-013-2562-z
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5
Development of an HPLC Method for Determination of Related Impurities in Prilocaine Substance
Autor: Linda C. Johansson, Magnus B.O. Andersson, Ingrid Granelli, Janina Sroka-Markovic
Publikováno v: Chromatographia. 75:329-336
Development of a reversed phase high performance liquid chromatographic method for determination of six related impurities in prilocaine substance is reported. The test of related impurities in European Pharmacopoeia (Ph. Eur.) cannot meet the demand
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f80d44a23345508d2406935964ea7b5f
https://doi.org/10.1007/s10337-012-2212-x
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6
Enantiomeric separation of TAPP, H–Tyr–(d)Ala–Phe–Phe–NH2, by capillary electrophoresis using 18-crown-6-tetracarboxylic acid as a chiral selector
Autor: Helena Brunnkvist, Bo Karlberg, Ingrid Granelli
Publikováno v: Journal of Chromatography B. 793:343-350
A capillary electrophoresis method for the enantiomeric separation of the tetrapeptide H–Tyr–( d )Ala–Phe–Phe–NH 2 (TAPP), has been developed and validated. The preferred background electrolyte (BGE) consisted of 0.1 M aqueous phosphoric ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8664f6d0bc84351c36180b23d1f4b1ff
https://doi.org/10.1016/s1570-0232(03)00354-4
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7
Correction: Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Autor: Ronnie P.-A. Berntsson, Aljona Saleh, Helge Gad, Martin Henriksson, Ingrid Almlöf, Cecilia E. Ström, Jordi Carreras Puigvert, Pål Stenmark, Fabienne Z. Gaugaz, Cecilia Lundin, Marie-Caroline Jacques-Cordonnier, Ulrika Warpman Berglund Thomas Helleday, Berglind Osk Einarsdottir, Roger Olofsson, Camilla Göktürk, Niklas Schultz, Maria Häggblad, Pawel Baranczewski, Anna-Lena Gustavsson, Olga Loseva, Per Artursson, Karl S. A. Vallin, Hanna Axelsson, Bo Lundgren, Tobias Koolmeister, Kia Strömberg, Christina Kalderén, Ulf Martens, Saeed Eshtad, Jonas Nilsson, Fredrik Johansson, Mikael Altun, Fredrik Jeppsson, Thomas Lundbäck, Evert Homan, Ann-Sofie Jemth, Martin Scobie, Anna Hagenkort, Lars Bräutigam, Annika Jenmalm Jensen, Andreas Höglund, Matthieu Desroses, Linda M. Svensson, Therese M. Pham, Richard Svensson, Kumar Sanjiv, Sylvain A. Jacques, Lars Hammarström, Elisee Wiita, Robert Gustafsson, Tatjana Djureinovic, Olov A. Wallner, Bastiaan Evers, Ingrid Granelli, Svante Vikingsson, Lars Johansson
Publikováno v: Nature. 544:508-508
Nature 508, 215–221 (2014); doi:10.1038/nature13181 In this Article, the structure of compound TH650 (4) in Fig. 4a was drawn incorrectly; the correct structure is shown as Fig. 1 to this Corrigendum. Preparative, spectroscopic and biological data
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e64f6574623c18f705fb61d14465e8fb
https://doi.org/10.1038/nature22083
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8
Evaluation of a direct high-capacity target screening approach for urine drug testing using liquid chromatography-time-of-flight mass spectrometry
Autor: Olof Beck, Aljona Saleh, Ingrid Granelli, Tomas Villén, Niclas Stephanson
Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 909
In this study a rapid liquid chromatography-time-of-flight mass spectrometry method was developed, validated and applied in order to evaluate the potential of this technique for routine urine drug testing. Approximately 800 authentic patient samples
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41866db44f0619af0c17d377773b836
https://pubmed.ncbi.nlm.nih.gov/23153637
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9
Development of a two-dimensional liquid chromatography system for isolation of drug metabolites
Autor: Mala Jayamanne, Agneta Tjernberg, Ingrid Granelli, Per-Olof Edlund
Publikováno v: Journal of pharmaceutical and biomedical analysis. 51(3)
The separation, isolation and identification of drug metabolites from complex endogenous matrices like urine, plasma and tissue extracts are challenging tasks. Metabolites are usually first identified by mass spectrometry and tentative structures pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c773a620720bbb93ff0ce863ed3ced
https://pubmed.ncbi.nlm.nih.gov/19815360
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10
Experimental design as a tool when evaluating stationary phases for the capillary electrochromatographic separation of basic peptides
Autor: Bo Karlberg, Linda Gunnarsson, Helena Brunnkvist, Ingrid Granelli
Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 813(1-2)
Two different capillary electrochromatography (CEC) stationary phases, Hypersil phenyl and Hypersil C(18), have been characterised with respect to their ability to separate the four basic peptides H-Tyr-(D)Ala-Phe-Phe-NH(2) (TAPP), H-Tyr-(D)Ala-Phe-N
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00496ac40dbec926de993e4d4c297d2
https://pubmed.ncbi.nlm.nih.gov/15556517
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