Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Ingrid, Dach"'
2
The Na,K-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state
Autor: Marlene U. Fruergaard, Ingrid Dach, Jacob L. Andersen, Mette Ozol, Azadeh Shahsavar, Esben M. Quistgaard, Hanne Poulsen, Natalya U. Fedosova, Poul Nissen
Publikováno v: Fruergaard, M U, Dach, I, Andersen, J L, Ozol, M, Shasavar, A, Quistgaard, E M H, Poulsen, H, Fedosova, N & Nissen, P 2022, ' The Na,K-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. ', Journal of Biological Chemistry, vol. 298, no. 9, 102317 . https://doi.org/10.1016/j.jbc.2022.102317
The journal of biological chemistry 298(9), 102317 (2022). doi:10.1016/j.jbc.2022.102317
JBC papers in press 298(9), 102317 (2022). doi:10.1016/j.jbc.2022.102317
The Na$^+$,K$^+$-ATPase generates electrochemical gradients of Na$^+$ and K$^+$ across the plasma membrane via a functional cycle that includes various phosphoenzyme interm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42c5d3878478c4bbbcd9041ed40d9ee
https://pure.au.dk/portal/da/publications/the-nakatpase-in-complex-with-beryllium-fluoride-mimics-an-atpase-phosphorylated-state(1db2fbbb-0727-405f-83c3-8325e923b576).html
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3
The beryllium fluoride form of the Na+,K+-ATPase and the intermediates of the functional cycle
Autor: Azadeh Shasavar, Hanne Poulsen, Natalya U. Fedosova, Mette Ozol, Marlene U. Fruergaard, Jacob Andersen, Poul Nissen, Esben M. Quistgaard, Ingrid Dach
The Na+,K+-ATPase generates electrochemical gradients of Na+ and K+ across the plasma membrane. Here, we describe a 4.0 Å resolution crystal structure of the pig kidney Na+,K+-ATPase stabilized by beryllium fluoride (denoted E2-BeFx). The structure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc2f8eacb851cca5c4db14deb9fcd1c8
https://doi.org/10.1101/2021.11.08.467847
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4
Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase
Autor: Maike Bublitz, Poul Nissen, Ditte F. Bonde, Ingrid Dach, Eleonora Tenori, Jesper V. Møller, Henriette Elisabeth Autzen, S. Brøgger Christensen, Pankaj Sehgal, Mette Alstrup Lie, Jesper Villadsen, Eleonora S. Paulsen, Claus Olesen, Birgit Schiøtt, Huizhen Liu
Publikováno v: Paulsen, E S, Villadsen, J, Tenori, E, Liu, H, Bonde, D F, Lie, M A, Bublitz, M, Olesen, C, Autzen, H E, Dach, I, Sehgal, P, Nissen, P, Møller, J V, Schiøtt, B & Christensen, SB 2013, ' Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase ', Journal of Medicinal Chemistry, vol. 56, no. 9, pp. 3609-3619 . https://doi.org/10.1021/jm4001083
A crystal structure suggests four water molecules are present in the binding cavity of thapsigargin in sarco/endoplasmic reticulum calcium ATPase (SERCA). Computational chemistry indicates that three of these water molecules mediate an extensive hydr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d802cab50068369f30d05bb5317065
https://pubmed.ncbi.nlm.nih.gov/23574308
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5
Active Detergent-solubilized H+,K+-ATPase Is a Monomer
Autor: Christine Ebel, Jesper V. Møller, Poul Nissen, Claus Olesen, Marc le Maire, Luca Signor, Ingrid Dach
Publikováno v: Dach, I, Olesen, C, Signor, L, Nissen, P, le Maire, M, Møller, J V & Ebel, C 2012, ' Active Detergent-solubilized H +,K +-ATPase Is a Monomer ', Journal of Biological Chemistry, vol. 287, pp. 41963-41978 . https://doi.org/10.1074/jbc.M112.398768
Journal of Biological Chemistry
The H(+),K(+)-ATPase pumps protons or hydronium ions and is responsible for the acidification of the gastric fluid. It is made up of an α-catalytic and a β-glycosylated subunit. The relation between cation translocation and the organization of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78b0075032107e7eb771c8df43316bc
https://pure.au.dk/portal/da/publications/active-detergentsolubilized-hkatpase-is-a-monomer(780b6bce-52c2-4e65-a095-994f0de32df2).html
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7
Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy
Autor: Poul Nissen, George Wilding, Annastasiah Mhaka, Claus Olesen, S. Brøgger Christensen, Craig A. Dionne, W. Nathaniel Brennen, Michael A. Carducci, Jesper V. Møller, Ingrid Dach, Samuel R. Denmeade, Susan L. Dalrymple, Bora Gurel, John T. Isaacs, D. Marc Rosen, Angelo M. DeMarzo
Publikováno v: Denmeade, S R, Mhaka, A M, Rosen, D M, Brennen, W N, Dalrymple, S, Dach, I, Olesen, C, Gurel, B, Demarzo, A M, Wilding, G, Carducci, M A, Dionne, C A, Møller, J V, Nissen, P, Christensen, S B & Isaacs, J T 2012, ' Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy ', Science Translational Medicine, vol. 4, no. 140, pp. 140ra86 . https://doi.org/10.1126/scitranslmed.3003886
Heterogeneous expression of drug target proteins within tumor sites is a major mechanism of resistance to anticancer therapies. We describe a strategy to selectively inhibit, within tumor sites, the function of a critical intracellular protein, the s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c395bd47d66aef53e9308b2fe53c46
https://pure.au.dk/portal/da/publications/engineering-a-prostatespecific-membrane-antigenactivated-tumor-endothelial-cell-prodrug-for-cancer-therapy(9a10fc11-b923-4299-b981-dd290c0310fe).html
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