Scavengers of hemoproteins as potential biomarkers for severe sepsis and septic shock

Autor: Myrddin W. Verheij, Ingrid Bulder, Walter A. Wuillemin, Carlijn Voermans, Sacha S. Zeerleder

Publikováno v: Translational Medicine Communications, Vol 6, Iss 1, Pp 1-5 (2021)

Abstract Background Despite improvements in diagnosis, interventions and supportive care, mortality among sepsis patients is still high. Research of the past decade has attempted to identify biomarkers that can accurately discriminate sepsis from oth

Externí odkaz: https://doaj.org/article/9e36bd0d41414566aa950c4df6429d83

Cell-free DNA levels are increased in acute graft-versus-host disease

Autor: Anna Kroeze, Anne S. Cornelissen, M. Fernanda Pascutti, Myrddin Verheij, Ingrid Bulder, Sjoerd Klarenbeek, Aicha Ait Soussan, Mette D. Hazenberg, Erfan Nur, C. Ellen van der Schoot, Carlijn Voermans, Sacha S. Zeerleder

Publikováno v: European Journal of Haematology, 109(3), 271-281. Wiley-Blackwell
Kroeze, A, Cornelissen, A S, Pascutti, M F, Verheij, M, Bulder, I, Klarenbeek, S, Ait Soussan, A, Hazenberg, M D, Nur, E, van der Schoot, C E, Voermans, C & Zeerleder, S S 2022, ' Cell-free DNA levels are increased in acute graft-versus-host disease ', European Journal of Haematology, vol. 109, no. 3, pp. 271-281 . https://doi.org/10.1111/ejh.13806
European journal of haematology, 109(3), 271-281. Wiley-Blackwell

BACKGROUND Cell-free DNA (cfDNA) and nucleosomes, consisting of cfDNA and histones, are markers of cell activation and damage. In systemic inflammation these markers predict severity and fatality. However, the role of cfDNA in acute Graft-versus-Host

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe09d857d38b253da75a8aaf2d9e29e1
https://research.vumc.nl/en/publications/c7584cf8-43f4-451e-945b-abdf7a6669c5

Platelet concentrates in platelet additive solutions generate less complement activation products during storage than platelets stored in plasma

Autor: Yasmin E S, de Wit, Richard, Vlaar, Eric, Gouwerok, Hind, Hamzeh-Cognasse, Gerard, van Mierlo, Ingrid, Bulder, Johan W M, Lagerberg, Dirk, de Korte, Fabrice, Cognasse, Anja, Ten Brinke, Sacha S, Zeerleder

Publikováno v: Blood Transfus

BACKGROUND: Platelet transfusions can be associated with adverse reactions, such as febrile non-haemolytic transfusion reaction (FNHTR). It has been suggested that damage-associated molecular patterns (DAMP) and complement play a role in FNHTR. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db6b7d59ac0ac6ccacef89a3d1b0858a
https://pubmed.ncbi.nlm.nih.gov/35302481

Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos.

Autor: Daniel H Paris, Femke Stephan, Ingrid Bulder, Diana Wouters, Tom van der Poll, Paul N Newton, Nicholas P J Day, Sacha Zeerleder

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0003990 (2015)

Cell-mediated immunity is essential in protection against rickettsial illnesses, but the role of neutrophils in these intracellular vasculotropic infections remains unclear. This study analyzed the plasma levels of nucleosomes, FSAP-activation (nucle

Externí odkaz: https://doaj.org/article/74103ff23ebd4511b8df58cc6b3fe91b

FSAP-mediated nucleosome release from late apoptotic cells is inhibited by autoantibodies present in SLE

Autor: Femke Stephan, Cees G. M. Kallenberg, Irene E. M. Bultink, Lucien A. Aarden, Alexandre E. Voskuyl, Jan de Jong, Ingrid Bulder, Johanna Westra, Sacha Zeerleder, Brenda M. Luken, Karina de Leeuw, Jessica T Ruinard, Gerben Marsman

Publikováno v: European Journal of Immunology, 46(3), 762-771. Wiley-VCH Verlag
Marsman, G, Stephan, F, de Leeuw, K, Bulder, I, Ruinard, J T, Westra, J, Bultink, I E M, Voskuyl, A E, Aarden, L A, Luken, B M, Kallenberg, C G M & Zeerleder, S 2016, ' FSAP-mediated nucleosome release from late apoptotic cells is inhibited by autoantibodies present in SLE ', European Journal of Immunology, vol. 46, no. 3, pp. 762-771 . https://doi.org/10.1002/eji.201546010
European Journal of Immunology, 46(3), 762-771. Wiley
European journal of immunology, 46(3), 762-771. Wiley-VCH Verlag

Inefficient clearance of apoptotic cells and the subsequent exposure of the immune system to nuclear contents are crucially involved in the pathogenesis of systemic lupus erythematosus (SLE). Factor VII-activating protease (FSAP) is activated in seru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2bb948a7619ae02d6ca4c2b7a20604
https://doi.org/10.1002/eji.201546010