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Akademický článek

Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

Autor: Matthias Weuster, Philipp Mommsen, Roman Pfeifer, Juliane Mohr, Steffen Ruchholtz, Sascha Flohé, Matthias Fröhlich, Claudia Keibl, Andreas Seekamp, Martijn van Griensven, Ingo Witte

Publikováno v: Mediators of Inflammation, Vol 2015 (2015)

Background. The deterioration of hemodynamics instantly endangers the patients’ life after polytrauma. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the cardiop

Externí odkaz: https://doaj.org/article/81e895caea3b4a27990bad9c8d44e8d1

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Akademický článek

Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma

Autor: Wei Meng, Adnana Paunel-Görgülü, Sascha Flohé, Ingo Witte, Michael Schädel-Höpfner, Joachim Windolf, Tim Tobias Lögters

Publikováno v: Mediators of Inflammation, Vol 2012 (2012)

Introduction. Neutrophil extracellular traps (NET) consist of a DNA scaffold that can be destroyed by Deoxyribonuclease (DNase). Thus DNases are potential prerequisites for natural counter regulation of NETs formation. In the present study, we determ

Externí odkaz: https://doaj.org/article/18e38d8a1cec4e95945c3acc3842e157

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Induced hypothermia does not impair coagulation system in a swine multiple trauma model

Autor: Martijn van Griensven, Claudia Keibl, Juliane Mohr, Matthias Weuster, Michael Frink, Matthias Fröhlich, Sascha Flohé, Frank Hildebrand, Philipp Mommsen, Steffen Ruchholtz, Ingo Witte

Publikováno v: Journal of Trauma and Acute Care Surgery. 74(4):1014-1020

BACKGROUND: Accidental hypothermia, acidosis, and coagulopathy represent the lethal triad in severely injured patients. Therapeutic hypothermia however is commonly used in transplantations, cardiac and neurosurgical surgery, or after cardiac arrest.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46c126a2bd66981622469193d24e4b3
https://doi.org/10.1097/TA.0b013e3182826edd

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A Combined Trauma Model of Chest and Abdominal Trauma With Hemorrhagic Shock—Description of a New Porcine Model

Autor: Sascha Flohé, Matthias Fröhlich, Martijn van Griensven, Andreas Seekamp, Ingo Witte, Frank Hildebrand, Matthias Weuster, Hans-Christoph Pape, Steffen Ruchholtz, Claudia Keibl, Philipp Mommsen, Juliane Mohr

Publikováno v: Shock. 38:664-670

Despite the high incidence and prognostic relevance of hemorrhagic shock and abdominal and blunt chest trauma in multiply injured patients, there are no animal models combining these injuries. Therefore, we established a new porcine multiple trauma m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1d3c29331af4689d1f99242a7159e8
https://doi.org/10.1097/shk.0b013e3182709c90

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Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

Autor: Claudia Keibl, Roman Pfeifer, Andreas Seekamp, Matthias Weuster, Sascha Flohé, Philipp Mommsen, Martijn van Griensven, Ingo Witte, Juliane Mohr, Matthias Fröhlich, Steffen Ruchholtz

Publikováno v: Mediators of Inflammation
Mediators of Inflammation, Vol 2015 (2015)
Mediators of Inflammation, 2015. Hindawi Publishing Corporation
Mediators of inflammation 2015, 1-11 (2015). doi:10.1155/2015/829195

Mediators of inflammation 2015, 1-11 (2015). doi:10.1155/2015/829195
Published by Hindawi Publishing Corp., Sylvania, Ohio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74afd9eba08057d4965d5b1d0e258b89

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Induced hypothermia reduces the hepatic inflammatory response in a swine multiple trauma model

Autor: Hans-Christoph Pape, Sascha Flohé, Matthias Weuster, Roman Pfeifer, Ingo Witte, Steffen Ruchholtz, Martijn van Griensven, Pierre Raeven, Frank Hildebrand, Philipp Mommsen, Matthias Fröhlich, Juliane Mohr

Publikováno v: Journal of Trauma and Acute Care Surgery, 76(6), 1425-32. LIPPINCOTT WILLIAMS & WILKINS

BACKGROUND: Mild therapeutic hypothermia following trauma has been introduced in several studies to reduce the posttraumatic inflammation and organ injury. In this study, we analyzed the effects of induced mild hypothermia (34-C) on the inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468fbfd8476398f751bac10ee96f1e0b
https://pubmed.ncbi.nlm.nih.gov/24854311

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Induced Hypothermia Preserves the Functional Enterocyte Mass in A Porcine Multiple Trauma Model

Autor: Ingo Witte, Sascha Flohé, Frank Hildebrand, Juliane Mohr, Philipp Mommsen, Martijn van Griensven, Roman Pfeifer, Georg A. Feichtinger, Matthias Weuster, Matthias Fröhlich, Claudia Keibl, Marc Maegele

Publikováno v: SHOCK. :1

INTRODUCTION Multiple organ dysfunction syndrome (MODS) and the resulting multiple organ failure (MOF) following severe trauma are associated with increased morbidity and mortality. Due to intestinal mucosal lesions and gut barrier disorders, the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a108aa4ed3f8e2fe6c3100e6f7180adc
https://doi.org/10.1097/shk.0000000000000626

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Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma

Autor: Sascha Flohé, Tim Lögters, Wei Meng, Ingo Witte, M. Schädel-Höpfner, Adnana Paunel-Görgülü, Joachim Windolf

Publikováno v: Mediators of Inflammation, Vol 2012 (2012)
Mediators of Inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a223ad8e2faf3767aa0276c8a121d3b
https://doaj.org/article/18e38d8a1cec4e95945c3acc3842e157

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