Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Ingo Tornus"'
1
Finerenone and Cardiovascular Outcomes in Patients with Chronic Kidney Disease and Type 2 Diabetes
Autor: Patrick Schloemer, Amer Joseph, Rajiv Agarwal, George Bakris, Peter Rossing, Bertram Pitt, Luis M. Ruilope, Gerasimos Filippatos, Stefan D. Anker, Ingo Tornus, Peter Kolkhof
Publikováno v: FIDELIO-DKD Investigators 2021, ' Finerenone and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Type 2 Diabetes ', Circulation, vol. 143, no. 6, pp. 540-552 . https://doi.org/10.1161/CIRCULATIONAHA.120.051898
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
Circulation
Supplemental Digital Content is available in the text.
Background: The FIDELIO-DKD trial (Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease) evaluated the effect of the nonsteroidal, selective mineralocorti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a524b74c535a185c76bdb9a04a196e
https://hdl.handle.net/11268/9624
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2
Synthesis and Cyclization Reactions of Axially ChiralN-Sulfamoyl-acrylamidines
Autor: Eike G. Hübner, Ernst Schaumann, Andreas Lender, Ingo Tornus
Publikováno v: Heteroatom Chemistry. 25:619-627
N-Sulfonylamines are generated and in situ reacted with 3-dialkylamino-2H-azirines to give N-sulfamoyl-acrylamidines. The magnetic nonequivalence of prochiral groups in the 1H NMR spectrum suggests an axially chiral structure, which is supported by d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bc14fccc38af102e601a0f47f71005d
https://doi.org/10.1002/hc.21190
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4
Biosynthesis of the Validamycins: Identification of Intermediates in the Biosynthesis of Validamycin A by Streptomyces hygroscopicus var. limoneus
Autor: Haijun Dong, Ingo Tornus, Sungsook Lee, Taifo Mahmud, Heinz G. Floss
Publikováno v: Journal of the American Chemical Society. 123:2733-2742
To study the biosynthesis of the pseudotrisaccharide antibiotic, validamycin A (1), a number of potential precursors of the antibiotic were synthesized in (2)H-, (3)H-, or (13)C-labeled form and fed to cultures of Streptomyces hygroscopicus var. limo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe3eed5713e2f76eae935e336412db3
https://doi.org/10.1021/ja003643n
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5
Biosynthetic Studies on the α-Glucosidase Inhibitor Acarbose in Actinoplanes sp.: 2-epi-5-epi-Valiolone Is the Direct Precursor of the Valienamine Moiety
Autor: Charmaine Uy, Erin Egelkrout, Eckardt Wolf, Taifo Mahmud, Heinz G. Floss, Ingo Tornus, Sungsook Lee
Publikováno v: Journal of the American Chemical Society. 121:6973-6983
The biosynthetic pathway leading to the mC7N cyclitol (valienamine) moiety of acarbose (1) in Actinoplanes sp. strain SN 223/29 has been studied using 3H-, 2H-, and 13C-labeled cyclitols. These pre...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5b72ae8b26ad631b956ef9ea7a24efd
https://doi.org/10.1021/ja991102w
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6
Synthesis of [7‐ 3 H]valienamine, [7‐ 3 H]valienone, [7‐ 3 H]valiolamine and [7‐ 3 H]valiolone from validamycin A
Autor: Sungsook Lee, Haijun Dong, Ingo Tornus, Stefan Gröger
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 42:361-372
To investigate the biosynthetic pathway to the cyclitol moieties of acarbose and validamycin A, [7-3H]valienamine, [7-3H]valienone, [7-3H]valiolamine and [7-3H]valiolone were synthesized as plausible precursors. Valienamine together with validamine w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55f48ae21401c5e2f2169e7c06672d9a
https://doi.org/10.1002/(sici)1099-1344(199904)42:4<361::aid-jlcr197>3.0.co
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7
Novel applications of N-sulfonyl-alkylamines in [2+4] cycloadditions
Autor: Ernst Schaumann, Ingo Tornus
Publikováno v: Tetrahedron. 52:725-732
N-Sulfonylamine 2c was generated from the corresponding sulfamoyl chloride 1c at - 78 °C by triethylamine-induced dehydrohalogenation or from the novel precursor 5 with a phthalimidyl leaving group at room temperature. Trapping of 2c from either sou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2125a359c8d332283c91335d1359feba
https://doi.org/10.1016/0040-4020(95)01032-7
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8
Novel reactions of N-sulfonylamines with 3-dimethylamino-2H-azirines. Competitive formation of 1,2,5-thiadiazoles, 1,2,3-oxathiazoles and acrylamidines. X-Ray molecular structure of N-(4-dimethylamino-5-methyl-2-oxo-5-phenyl-5H-1,2λ6,3-oxathiazol-2-ylidene)benzamide
Autor: Ernst Schaumann, Ingo Tornus, Gunadi Adiwidjaja
Publikováno v: J. Chem. Soc., Perkin Trans. 1. :1629-1633
Reaction of 3-dimethylamino-2,2-diphenyl-2H-azirine 3a with N-sulfonylalkyamines 2a,b provides 1,2,5-thiadiazoles 5a,b, whereas use of N-carbonylsulfonylamines 2c,e as reaction partners primarily results in 1,2,3-oxathiazoles 6a,b which isomerise to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d68d09a6137653bf7eae2f268613285b
https://doi.org/10.1039/p19960001629
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9
Reactions ofN-sulfonylalkylamines with ynamines — formation of 2H-1,2-thiazete 1,1-dioxides, novel thioketeneS,S-dioxide dimers, and other s,n-heterocycles
Autor: Ingo Tornus, Gunadi Adiwidjaja, Roland Mayer, Ernst Schaumann
Publikováno v: Liebigs Annalen. 1995:1795-1800
N-Sulfonylalkylamines 2a, b react with ynamines 3 to give primarily 2H-1,2-thiazete 1,1-dioxides 4. But, except for the 4-triphenylsilyl species 4a, b, these products are unstable and undergo electrocyclic ring opening to very reactive amidinosulfene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea3adc1d149fd89e1eb6b078e80e5453
https://doi.org/10.1002/jlac.1995199510251
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10
ChemInform Abstract: Reactions of N-Sulfonylalkylamines with Ynamines - Formation of 2H-1,2- Thiazete 1,1-Dioxides, Novel Thioketene S,S-Dioxide Dimers, and Other S,N-Heterocycles
Autor: Ernst Schaumann, Roland Mayer, Ingo Tornus, Gunadi Adiwidjaja
Publikováno v: ChemInform. 27
N-Sulfonylalkylamines 2a, b react with ynamines 3 to give primarily 2H-1,2-thiazete 1,1-dioxides 4. But, except for the 4-triphenylsilyl species 4a, b, these products are unstable and undergo electrocyclic ring opening to very reactive amidinosulfene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25f10ba0865b49164f48e2e992b5dfc4
https://doi.org/10.1002/chin.199603114
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