Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ingo Spreitzer"'
Autor:
Stefan Schülke, Sonja Wolfheimer, Gabriele Gadermaier, Andrea Wangorsch, Susanne Siebeneicher, Peter Briza, Ingo Spreitzer, Dirk Schiller, Bettina Loeschner, Satoshi Uematsu, Bernard Ryffel, Shizuo Akira, Zoe Waibler, Stefan Vieths, Masako Toda, Stephan Scheurer
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87822 (2014)
Conjugated vaccines consisting of flagellin and antigen activate TLR5 and induce strong innate and adaptive immune responses. Objective of the present study was to gain further insight into the mechanisms by which flagellin fusion proteins mediate th
Externí odkaz:
https://doaj.org/article/5bb21d8253d24bf7bfc9cc1b48fd7974
Autor:
Max Bastian, Milena Hasan, Anja Ullrich, Brigitte David-Watine, Stefan Schülke, Spencer Louis Shorte, Bianca Walber, Christel Kamp, Laura Roßmann, Anna-Lisa Gerards, Tharshana Stephen, Ger van Zandbergen, Ingo Spreitzer, Katrin Bagola
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (39), pp.1073-1081. ⟨10.1073/pnas.2103651118⟩
Proceedings of the National Academy of Sciences of the United States of America, 118(39):e2103651118
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (39), pp.1073-1081. ⟨10.1073/pnas.2103651118⟩
Proceedings of the National Academy of Sciences of the United States of America, 118(39):e2103651118
Significance Vaccines profit from the addition of adjuvants to better and more specifically initiate, amplify, and shape immune responses. Although the number of adjuvant candidates has steadily increased, peaking in the current SARS-CoV-2 pandemic,
Autor:
Barbara S. Schnierle, Roland Grzeschik, Olympia E. Anastasiou, Sebastian Schlücker, Vi Tran, Sibylle Pagel-Wieder, Ulf Dittmer, Supriya Srivastav, Tatjana Scholz, Mujo Adanalic, Ingo Spreitzer, Asen Dankov, Frank Gessler
As an immune response to COVID-19 infection, patients develop SARS-CoV-2-specific IgM/IgG antibodies. Here, we compare the performance of a conventional lateral flow assay (LFA) with a surface-enhanced Raman scattering (SERS)-based LFA test for the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef33587a76f9d969fb1f7214b89c1463
https://www.ncbi.nlm.nih.gov/pubmed/34468139
https://www.ncbi.nlm.nih.gov/pubmed/34468139
Autor:
Tina Morris, Friedrich von Wintzingerode, Ingo Spreitzer, Ned M. Mozier, Jay S. Bolden, Chris Knutsen, Jack Levin, Catherine Milne
Publikováno v:
PDA journal of pharmaceutical science and technology. 74(5)
Endotoxin testing by recombinant factor C (rFC) is increasing with the addition of new suppliers of reagents. By use of a recombinantly produced factor C , based on the sequence of a coagulation enzyme present in horseshoe crab amebocyte lysates, the
Autor:
Daniela Ricci, Elena Giacomini, Eliana M. Coccia, Martina Severa, Sara Valentini, Shahjahan Shaid, Christina von Hunolstein, Luisa Galli Stampino, Ingo Spreitzer, Fabiana Rizzo, Marilena P. Etna, Liliana Alleri, Denis Lambrigts, Andrea Gaggioli
Publikováno v:
ALTEX
Alternatives to animal experimentation, 37(4):532-544
Alternatives to animal experimentation, 37(4):532-544
Pyrogen content is a key quality feature that must be checked in all injectable products, including vaccines. Four tests are currently available in the European Pharmacopoeia to monitor pyrogen/endotoxin presence: 1) the Rabbit Pyrogen Test (RPT), 2)
Autor:
Ingo Spreitzer, Laura Rebernik, Sven Benson, Harald Engler, Sigrid Elsenbruch, Manfred Schedlowski, Alexander Wegner
Publikováno v:
Clinical Pharmacology & Therapeutics. 102:141-151
We aimed to identify statistical predictor variables of lipopolysaccharide (LPS)-induced physical sickness symptoms during the acute and late inflammatory phases using multivariate regression analyses. Data from N = 128 healthy volunteers who receive
Autor:
Ingo Spreitzer
Publikováno v:
Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems ISBN: 9783030171476
The MAT as well as the RPT provide information about the biological impact of the sample, whereas the BET determines the Endotoxin content (Table 14.1). Consequently the RPT and the MAT are better performed as end-product assays (a failed batch is lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a00ba68cc1275c2d1de5c0af98ce106d
https://doi.org/10.1007/978-3-030-17148-3_14
https://doi.org/10.1007/978-3-030-17148-3_14
Autor:
L. Häckel, Utta Schurig, U. Sicker, E. Spindler-Raffel, Ingo Spreitzer, I. Bekeredjian-Ding, Jan-Oliver Karo
Publikováno v:
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 58:1225-1232
Ensuring microbiological safety in advanced-therapy medicinal products is still a big challenge for manufacturers. There are fundamental problems, especially in cell-based medicinal products, regarding sterility of source materials, short shelf-life
Autor:
Janina Maluck, Alexander Wegner, Sigrid Elsenbruch, Jan-Sebastian Grigoleit, Harald Engler, Ingo Spreitzer, Sven Benson, Manfred Schedlowski, Marcus Jäger
Publikováno v:
Brain, Behavior, and Immunity. 41:46-54
Background Inflammation-induced pain amplification and hypersensitivity play a role in the pathophysiology of numerous clinical conditions. Experimental endotoxemia has recently been implemented as model to analyze immune-mediated processes in human
Autor:
Sven Benson, Alexander Wegner, Ingo Spreitzer, Laura Rebernik, Sigrid Elsenbruch, Manfred Schedlowski, Marcus Jäger, Harald Engler
Publikováno v:
Innate immunity. 23(5)
Clinical data indicate that inflammatory responses differ across sexes, but the mechanisms remain elusive. Herein, we assessed in vivo and ex vivo cytokine responses to bacterial endotoxin in healthy men and women to elucidate the role of systemic an