Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ingo Presser"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2783 (2023)
Microwave-assisted freeze-drying (MFD) offers significant time savings compared to conventional freeze-drying (CFD). While a few studies have investigated the stability of biopharmaceuticals with low protein concentrations after MFD and storage, the
Externí odkaz:
https://doaj.org/article/9aa49e8e48554893afb0b1f816931131
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1342 (2023)
Recently, attention has been drawn to microwave-assisted freeze-drying (MFD), as it drastically reduces the typically long drying times of biopharmaceuticals in conventional freeze-drying (CFD). Nevertheless, previously described prototype machines l
Externí odkaz:
https://doaj.org/article/e10af07b3fe84658a20c98b1fbd1092c
Autor:
Daniel Molnar, Martina Röhm, Johannes Wutz, Ingrid Rivec, Annika Michel, Gina Klotz, Jürgen Hubbuch, Katharina Schindowski, Ingo Presser
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics, 178, 117–130
During the filling process of a biopharmaceutical drug product (DP), a liquid DP film might creep up the inner vial wall which is barely discernible, appears as milky-white haze after lyophilisation and is known as fogging. Creeping and fogging are m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662b433a507bdaa245a8a68b22693db2
https://doi.org/10.1016/j.ejpb.2022.08.003
https://doi.org/10.1016/j.ejpb.2022.08.003
Publikováno v:
PDA journal of pharmaceutical science and technology. 76(2)
Freeze-drying is the drying technology of choice for sensitive biological drugs. On the one side, it is admired for its suitability for the stabilization of sensitive molecules. On the other side, it is a time-consuming production step posing challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52394614c29303a46d4c80685433af28
https://pubmed.ncbi.nlm.nih.gov/34131013
https://pubmed.ncbi.nlm.nih.gov/34131013
Publikováno v:
Journal of Pharmaceutical Sciences. 107:2748-2754
The aim of this study was to investigate if mechanistically different controlled ice nucleation techniques in freeze-drying are comparable to each other with respect to drying process performance and product quality attributes. Therefore, we studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f2270e5cbd9795162d4951b25c8876
https://doi.org/10.1016/j.xphs.2018.07.019
https://doi.org/10.1016/j.xphs.2018.07.019
Autor:
Patrick Garidel, Ingo Presser
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781493989270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9954954a523ec2015e0b0d5465397b95
https://doi.org/10.1007/978-1-4939-8928-7_12
https://doi.org/10.1007/978-1-4939-8928-7_12
Publikováno v:
International journal of pharmaceutics. 552(1-2)
Biotherapeutic protein formulations are often high concentration liquid protein solutions, which are required to be stable under pharmaceutically relevant storage conditions and presence of external stress. Non-ionic detergents like polysorbate have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f41b9cafd9bb5c0c51c886ced8e350f
https://pubmed.ncbi.nlm.nih.gov/30300706
https://pubmed.ncbi.nlm.nih.gov/30300706
Publikováno v:
Journal of pharmaceutical sciences. 107(10)
Microwave-assisted freeze-drying (MFD) is a rapid drying process well known in food technology. However, little is known about its application to biologicals. In this study, we investigated the applicability and feasibility of this technology to diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b94c53157e9198c2559b6219fbfd97c
https://pubmed.ncbi.nlm.nih.gov/29890173
https://pubmed.ncbi.nlm.nih.gov/29890173
Publikováno v:
Pharmaceutics
Volume 11
Issue 12
Volume 11
Issue 12
In order to overcome the downside of long conventional freeze-drying (CFD) process times for monoclonal antibody formulations, microwave-assisted freeze-drying (MFD) was introduced. Recently, the general applicability and potential shortening of dryi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e2c9f90e968b8bf3b9b353b5830634
https://doi.org/10.3390/pharmaceutics11120674
https://doi.org/10.3390/pharmaceutics11120674
Autor:
Barbara Enenkel, Mathias Knappenberger, Ingo Presser, Alexander Jacobi, Hitto Kaufmann, Christian Eckermann, Patrick Garidel
Publikováno v:
Handbook of Therapeutic Antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba40bc8d618ea069bd4aeb16cab4d71f
https://doi.org/10.1002/9783527682423.ch22
https://doi.org/10.1002/9783527682423.ch22