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177Lu-3BP-227 for Neurotensin Receptor 1–Targeted Therapy of Metastatic Pancreatic Adenocarcinoma: First Clinical Results

Autor: Christiane Smerling, Ulrich Reineke, Christiane Schuchardt, Aviral Singh, Harshad R. Kulkarni, Richard P. Baum, Stefan Wiessalla, Frank Osterkamp, Ingo Klette

Publikováno v: Journal of Nuclear Medicine. 59:809-814

Neurotensin receptor 1 (NTR1) is overexpressed in ductal pancreatic adenocarcinoma, which is still one of the deadliest cancers, with a very poor prognosis. Eligible patients were offered salvage radiopharmaceutical therapy with the novel NTR1 antago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ac3a07cb03a3c7b37ebf861f59b68f7
https://doi.org/10.2967/jnumed.117.193847

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First-in-Human PET/CT Imaging of Metastatic Neuroendocrine Neoplasms with Cyclotron-Produced 44Sc-DOTATOC: A Proof-of-Concept Study

Autor: Harshad R. Kulkarni, Nicholas P. van der Meulen, Aviral Singh, Andreas Türler, Ingo Klette, Richard P. Baum, Cristina Müller, Roger Schibli

Publikováno v: Cancer Biotherapy and Radiopharmaceuticals. 32:124-132

44Sc is a promising positron emission tomography (PET) radionuclide (T1/2 = 4.04 hours, Eβ+average = 632 keV) and can be made available, using a cyclotron production route, in substantial quantities as a highly pure product. Herein, the authors repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a500dbd3f56843b9f03a9045f68d41c4
https://doi.org/10.1089/cbr.2016.2173

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177Lu-Labeled Prostate-Specific Membrane Antigen Radioligand Therapy of Metastatic Castration-Resistant Prostate Cancer: Safety and Efficacy

Autor: Hans-Jürgen Wester, Christiane Schuchardt, Dirk Mueller, Stefan Wiessalla, Richard P. Baum, Martina Wirtz, Margret Schottelius, Aviral Singh, Ingo Klette, Harshad R. Kulkarni

Publikováno v: Journal of Nuclear Medicine. 57:1006-1013

The objective of this study was to analyze the safety and efficacy of the 177Lu-labeled DOTAGA-based prostate-specific membrane antigen (PSMA) ligand 177Lu-DOTAGA-(I-y)fk(Sub-KuE) (177Lu-PSMA) in patients with metastatic castration-resistant prostate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86e5fa083acb20dc84ab0932ce734e9
https://doi.org/10.2967/jnumed.115.168443

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Radiolabeling of DOTA-like conjugated peptides with generator-produced Ga-68 and using NaCl-based cationic elution method

Autor: Andreas Odparlik, Ingo Klette, Dirk Mueller, Michael K. Schultz, Wouter A.P. Breeman, Michael Gottschaldt, Manfred Baehre, Izabela Tworowska

Publikováno v: Nature protocols
Nature Protocols, 11(6), 1057-1066. Nature Publishing Group

Gallium-68 ((68)Ga) is a generator-produced radionuclide with a short half-life (t½ = 68 min) that is particularly well suited for molecular imaging by positron emission tomography (PET). Methods have been developed to synthesize (68)Ga-labeled imag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce4b0397fbe017824add332f38b6c0b
https://doi.org/10.1038/nprot.2016.060

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68Ga- and 177Lu-Labeled PSMA I&T: Optimization of a PSMA-Targeted Theranostic Concept and First Proof-of-Concept Human Studies

Autor: Martina Weineisen, Matthias Eiber, Akin Yildiz, Jakub Šimeček, Hans-Jürgen Wester, Michael Lassmann, Markus Schwaiger, Seval Beykan, Margret Schottelius, Ingo Klette, Richard P. Baum, Harshad R. Kulkarni

Publikováno v: Journal of Nuclear Medicine. 56:1169-1176

On the basis of the high and consistent expression of prostate-specific membrane antigen (PSMA) in metastatic prostate cancer (PC), the goal of this study was the development, preclinical evaluation, and first proof-of-concept investigation of a PSMA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ca5fb58834b786b6418392cfa57b9b
https://doi.org/10.2967/jnumed.115.158550

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Theranostic Perspectives in Prostate Cancer with the Gastrin Releasing Peptide Receptor Antagonist NeoBOMB1: Preclinical and First Clinical Results

Autor: Harshad R. Kulkarni, Theodosia Maina, Richard P. Baum, Emmanouil Lymperis, Marion de Jong, Athina Giarika, Ingo Klette, Aikaterini Kaloudi, Aviral Singh, Berthold A. Nock, Eric P. Krenning

Publikováno v: Journal of Nuclear Medicine, 58(1), 75-80. Society of Nuclear Medicine and Molecular Imaging

textabstractWe recently introduced the potent gastrin-releasing peptide receptor (GRPR) antagonist 68Ga-SB3 (68Ga-DOTA-p-Aminomethylaniline-diglycolic acid-DPhe-Gln-Trp-Ala-Val-Gly-His-Leu-NHEt), showing excellent tumor localizing efficacy in animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37743a407b935e66291df37649cf22e
https://pure.eur.nl/en/publications/7c0fef68-5c23-41a3-939c-c5bab5846ab4

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Simplified NaCl Based Ga-68 Concentration and Labeling Procedure for Rapid Synthesis of Ga-68 Radiopharmaceuticals in High Radiochemical Purity

Autor: Richard P. Baum, Michael K. Schultz, Dirk Mueller, Michael Gottschaldt, Ingo Klette, Wouter A.P. Breeman

Publikováno v: Bioconjugate Chemistry, 23(8), 1712-1717. American Chemical Society

A simple sodium chloride (NaCl) based (68)Ga eluate concentration and labeling method that enables rapid, high-efficiency labeling of DOTA conjugated peptides in high radiochemical purity is described. The method utilizes relatively few reagents and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8838302edc2782391d39fe695454781a
https://doi.org/10.1021/bc300103t

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Synthesis of O-(2-[18F]fluoroethyl)-l-tyrosine based on a cartridge purification method

Autor: Dirk Mueller, Ingo Klette, Richard P. Baum, Fabrizia Kalb

Publikováno v: Nuclear Medicine and Biology. 38:653-658

Introduction O -(2-[ 18 F]fluoroethyl)-l-tyrosine (FET) is widely used as a positron emission tomography tracer for brain tumors. Usually, a high-performance liquid chromatography (HPLC) purification at the end of the two-step synthesis is applied. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a497bf716479290c2d3377c6255d73bf
https://doi.org/10.1016/j.nucmedbio.2011.01.006

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InIII GaIII complexes of sugar-substituted tripodal trisalicylidene imines: The first68Ga-labelled sugar derivative

Autor: Richard P. Baum, Michael Gottschaldt, Ulrich S. Schubert, Dirk Müller, Martin Walther, Helmar Görls, Anne Pospiech, Carmen Bohlender, Ingo Klette

Publikováno v: European Journal of Inorganic Chemistry, 4298-4307. Wiley-VCH Verlag
ISSUE=28;STARTPAGE=4298;ENDPAGE=4307;ISSN=1434-1948;TITLE=European Journal of Inorganic Chemistry

Gallium and indium complexes derived from salicylaldimines of 1,1,1-tris(aminomethyl)ethane (TAME) with pendantxylose, glucose and galactose units have been synthesised as model compounds for potential application as radiotracers. The formed neutral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a93210f75a1d88b9c56510e31dd9702
https://doi.org/10.1002/ejic.200900561

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