Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ingo H. Engels"'
Autor:
Ruhma Syeda, Jie Xu, Adrienne E Dubin, Bertrand Coste, Jayanti Mathur, Truc Huynh, Jason Matzen, Jianmin Lao, David C Tully, Ingo H Engels, H Michael Petrassi, Andrew M Schumacher, Mauricio Montal, Michael Bandell, Ardem Patapoutian
Publikováno v:
eLife, Vol 4 (2015)
Piezo ion channels are activated by various types of mechanical stimuli and function as biological pressure sensors in both vertebrates and invertebrates. To date, mechanical stimuli are the only means to activate Piezo ion channels and whether other
Externí odkaz:
https://doaj.org/article/20a3d73548454cefb9bd2e849079a1d3
Autor:
Debra A O'Leary, Orzala Sharif, Paul Anderson, Buu Tu, Genevieve Welch, Yingyao Zhou, Jeremy S Caldwell, Ingo H Engels, Achim Brinker
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8348 (2009)
One therapeutic approach to Duchenne Muscular Dystrophy (DMD) recently entering clinical trials aims to convert DMD phenotypes to that of a milder disease variant, Becker Muscular Dystrophy (BMD), by employing antisense oligonucleotides (AONs) target
Externí odkaz:
https://doaj.org/article/59c4f7f2bd7f4cf6ad72b1fe9520a840
Autor:
Ted Liefeld, Li Wang, Michael R. Reich, Guoying K. Yu, Felipa A. Mapa, Judit Jané-Valbuena, Giordano Caponigro, Joseph Thibault, Michael F. Berger, Jill Cheng, Kavitha Venkatesan, Kalpana Jagtap, Nicolas Stransky, Nanxin Li, Ingo H. Engels, Lauren Murray, Anupama Reddy, Gad Getz, Dmitriy Sonkin, Barbara L. Weber, Aaron Shipway, Jodi Meltzer, Peter Finan, Todd R. Golub, Jianjun Yu, Adam A. Margolin, Robert C. Onofrio, Peter Aspesi, Michael D. Jones, Kristin G. Ardlie, Scott Mahan, Vivien W. Chan, Jennifer L. Harris, Gregory V. Kryukov, Wendy Winckler, Vic E. Myer, Manway Liu, Pichai Raman, Matthew Meyerson, Jill P. Mesirov, William R. Sellers, Christine D. Wilson, Stacey Gabriel, Joseph Lehar, Michael Morrissey, Robert Schlegel, Jeffrey A. Porter, Supriya Gupta, Emanuele Palescandolo, John Monahan, Charlie Hatton, Levi A. Garraway, Paula Morais, Laura E. MacConaill, Sungjoon Kim, Jordi Barretina, Eva Bric-Furlong, Markus Warmuth, Melanie de Silva, Adam Korejwa, Carrie Sougnez
Publikováno v:
Nature. 565:E5-E6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ecff74715ae5662d9f7ecce4b2fbac5
https://doi.org/10.1038/s41586-018-0722-x
https://doi.org/10.1038/s41586-018-0722-x
Autor:
Achim Brinker, Hsiao Ting Wang, Puiying Annie Mak, Eli Chapman, Ingo H. Engels, Orzala Sharif, Arthur L. Horwich, Peter G. Schultz, Steven M. Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:786-789
High-throughput screening of 700,000 small molecules has identified 235 inhibitors of the GroEL/GroES-mediated refolding cycle. Dose-response analysis of a subset of these hits revealed that 21 compounds are potent inhibitors of GroEL/GroES-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bcdefe6af05be6b54aab588e539888
https://doi.org/10.1016/j.bmcl.2013.12.100
https://doi.org/10.1016/j.bmcl.2013.12.100
Autor:
Joseph Thibault, Michael F. Berger, Markus Warmuth, Adam A. Margolin, Laura E. MacConaill, Scott Mahan, Vivien W. Chan, Levi A. Garraway, Vic E. Myer, Christine D. Wilson, Stacey Gabriel, Jill P. Mesirov, Dmitriy Sonkin, Eva Bric-Furlong, Aaron Shipway, Wendy Winckler, Anupama Reddy, Adam Korejwa, Carrie Sougnez, Felipa A. Mapa, Judit Jané-Valbuena, Gad Getz, John Monahan, Peter Aspesi, Kristin G. Ardlie, Barbara L. Weber, Jianjun Yu, Nicolas Stransky, Michael R. Reich, Ted Liefeld, Emanuele Palescandolo, Michael D. Jones, Charlie Hatton, William R. Sellers, Lauren Murray, Melanie de Silva, Paula Morais, Michael Morrissey, Robert Schlegel, Jordi Barretina, Joseph Lehar, Jeffrey A. Porter, Supriya Gupta, Nanxin Li, Robert C. Onofrio, Gregory V. Kryukov, Pichai Raman, Matthew Meyerson, Jennifer L. Harris, Guoying K. Yu, Jill Cheng, Kavitha Venkatesan, Kalpana Jagtap, Jodi Meltzer, Peter Finan, Sungjoon Kim, Li Wang, Ingo H. Engels, Giordano Caponigro, Todd R. Golub, Manway Liu
Publikováno v:
Nature
The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust preclinical model systems that reflect the genomic diversity of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea2b343d8b7c92d22e0d943912cb141
http://europepmc.org/articles/PMC3320027
http://europepmc.org/articles/PMC3320027
Autor:
Ingo H. Engels, Jie Xu, Andrew M. Schumacher, Mauricio Montal, Ardem Patapoutian, David C. Tully, Michael Bandell, Bertrand Coste, H. Michael Petrassi, Truc Huynh, Adrienne E. Dubin, Jianmin Lao, Jayanti Mathur, Jason T. Matzen, Ruhma Syeda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccc77fd24b055190a28d6739a4e590f2
https://doi.org/10.7554/elife.07369.008
https://doi.org/10.7554/elife.07369.008
Autor:
Jianmin Lao, Michael Bandell, H. Michael Petrassi, David C. Tully, Truc Huynh, Adrienne E. Dubin, Jie Xu, Jason T. Matzen, Jayanti Mathur, Mauricio Montal, Ruhma Syeda, Bertrand Coste, Andrew M. Schumacher, Ardem Patapoutian, Ingo H. Engels
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife, eLife Sciences Publication, 2015, 4, ⟨10.7554/eLife.07369⟩
eLife, 2015, 4, ⟨10.7554/eLife.07369⟩
eLife
eLife, eLife Sciences Publication, 2015, 4, ⟨10.7554/eLife.07369⟩
eLife, 2015, 4, ⟨10.7554/eLife.07369⟩
Within our bodies, cells and tissues are constantly being pushed and pulled by their surrounding environment. These mechanical forces are then transformed into electrical or chemical signals by cells. This process is crucial for many biological struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ea2dc5b561868248bd11761649e432
https://elifesciences.org/articles/07369
https://elifesciences.org/articles/07369
Publikováno v:
Journal of Biological Chemistry. 279:35047-35052
In many mammalian cell types, engagement of the TRAIL/Apo2L death receptors DR4 and DR5 alters mitochondrial physiology, thereby promoting the release of pro-apoptotic proteins normally contained within this organelle. A contemporary view of this pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846ce43438fff1cae63a0ab501e6db6a
https://doi.org/10.1074/jbc.m400708200
https://doi.org/10.1074/jbc.m400708200
Autor:
Reiner U. Jänicke, Sebastian Wesselborg, Gerburg M. Stein, Kirsten Lauber, Andreas Rothbart, Christoph P. Berg, Claus Belka, Ingo H. Engels, Klaus Schulze-Osthoff
Publikováno v:
Oncogene. 22:775-780
Activation of caspases has been demonstrated to be involved in thrombocytopenia and prolonged storage of platelet concentrates. Platelets represent enucleate cells that comprise all elements of the mitochondrial apoptosis pathway. However, no apoptot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a1ff5646df3c7c4c0b1bc212b080db
https://doi.org/10.1038/sj.onc.1206221
https://doi.org/10.1038/sj.onc.1206221
Autor:
Sebastian Wesselborg, Kirsten Lauber, A Rothbart, Christoph P. Berg, Stephan F. Schlosser, Ingo H. Engels, Klaus Schulze-Osthoff, Andrea Renz
Publikováno v:
Cell Death & Differentiation. 8:1197-1206
Although proteases of the caspase family are essential mediators of apoptosis in nucleated cells, in anucleate cells their presence and potential functions are almost completely unknown. Human erythrocytes are a major cell population that does not co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2444dabaaf611d96744044fb442aee1
https://doi.org/10.1038/sj.cdd.4400905
https://doi.org/10.1038/sj.cdd.4400905