Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ingo Bartholomäus"'
Autor:
Stephanie Everts, Nikolaos I. Kyratsous, Ingo Bartholomäus, Guokun Zhang, Marija Pesic, Joanna M. Watt, Naoto Kawakami, Miriam Wörner, Ping Fang, Reinhard Hohlfeld, H. Wekerle, Marsilius Mues, Joachim W. Ellwart, Isabel J. Bauer, Barry V. L. Potter
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proc. Natl. Acad. Sci. U.S.A. 114, E6381-E6389 (2017)
Proc. Natl. Acad. Sci. U.S.A. 114, E6381-E6389 (2017)
In experimental autoimmune encephalitis (EAE), autoimmune T cells are activated in the periphery before they home to the CNS. On their way, the T cells pass through a series of different cellular milieus where they receive signals that instruct them
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b476f2bc673a22acb3cea6e6db102b
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Clinical and Experimental Neuroimmunology. 4:27-35
To visualize the entire process of encephalitogenic T cell infiltration into the target organ, we performed intravital imaging by using two-photon microscopy in experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis. Intrav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6c31d82c2241e97b106cfaaf4c2eac4
https://doi.org/10.1111/cen3.12060
https://doi.org/10.1111/cen3.12060
Autor:
Hartmut Wekerle, Vigo Heissmeyer, Naoto Kawakami, Marija Pesic, Nikolaos I. Kyratsous, Ingo Bartholomäus
Publikováno v:
J. Clin. Invest. 123, 1192-1201 (2013)
Journal of Clinical Investigation
Journal of Clinical Investigation
Autoreactive T cells can infiltrate the CNS to cause disorders such as multiple sclerosis. In order to visualize T cell activation in the CNS, we introduced a truncated fluorescent derivative of nuclear factor of activated T cells (NFAT) as a real-ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8015fe333bc4030864e3134346cef39
https://doi.org/10.1172/jci67233
https://doi.org/10.1172/jci67233
Autor:
Thomas Thestrup, Naoto Kawakami, Ingo Bartholomäus, Gurumoorthy Krishnamoorthy, Marsilius Mues, Oliver Griesbeck, Hartmut Wekerle
Publikováno v:
Nature Medicine
Nature Medicine; Vol 19
Nature Medicine; Vol 19
To study T cell activation in vivo in real time, we introduced a newly developed fluorescence resonance energy transfer-based, genetically encoded calcium indicator into autoantigen-specific and non-autoantigen-specific CD4(+) T cells. Using two-phot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b31980012779ecb9d8016b207e26988
Publikováno v:
Immunological Reviews. 248:140-155
Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model of multiple sclerosis (MS), a human autoimmune disease. To explore how EAE and ultimately MS is induced, autoantigen-specific T cells were established, were labeled with fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24eb68f99af631a652578daa89c5d6fb
https://doi.org/10.1111/j.1600-065x.2012.01133.x
https://doi.org/10.1111/j.1600-065x.2012.01133.x
Autor:
Francesca Odoardi, Ingo Bartholomäus, Naoto Kawakami, Cassandra Flügel-Koch, Alexander Flügel, Wolfgang E. F. Klinkert, Thomas B. Issekutz, Hartmut Wekerle, Djordje Miljković, Christian Schläger, Joachim W. Ellwart
Publikováno v:
Nature. 462:94-98
The tissues of the central nervous system are effectively shielded from the blood circulation by specialized vessels that are impermeable not only to cells, but also to most macromolecules circulating in the blood. Despite this seemingly absolute sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addffd4ecde76e793a120cc9652a3ca4
https://doi.org/10.1038/nature08478
https://doi.org/10.1038/nature08478
Autor:
Sébastien Dutertre, Hanne Hastrup, Heinrich Betz, Alok Jha, Ingo Bartholomäus, Ulrik Gether, Volker Eulenburg, Annette Nicke, Laura Milan-Lobo, Harald H. Sitte
Publikováno v:
Journal of Biological Chemistry. 283:10978-10991
Different Na+/Cl--dependent neurotransmitter transporters of the SLC6a family have been shown to form dimers or oligomers in both intracellular compartments and at the cell surface. In contrast, the glycine transporters (GlyTs) GlyT1 and -2 have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9661c05df26aed027ee7c5871de2e90e
https://doi.org/10.1074/jbc.m800622200
https://doi.org/10.1074/jbc.m800622200
Publikováno v:
Biochemical and Biophysical Research Communications. 354:102-108
Calcium-permeable N-methyl-d-aspartate (NMDA) receptors are tetrameric cation channels composed of glycine-binding NR1 and glutamate-binding NR2 subunits, which require binding of both glutamate and glycine for efficient channel gating. In contrast,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5236f5c951b68b6e2bb56400f0182150
https://doi.org/10.1016/j.bbrc.2006.12.153
https://doi.org/10.1016/j.bbrc.2006.12.153
Autor:
Hod Dana, Gregor Witte, Lawrence C. Rome, Olga Garaschuk, Thomas Thestrup, Douglas S. Kim, Luigi Russo, Yuri Kovalchuk, Taylor Allen, Yajie Liang, Julia Litzlbauer, Marsilius Mues, Tsai Wen Chen, Oliver Griesbeck, Yvonne Laukat, Stefan Becker, Anselm Geiger, Christian Griesinger, Georgios Kalamakis, Ingo Bartholomäus
Publikováno v:
Nature Methods
The quality of genetically encoded calcium indicators (GECIs) has improved dramatically in recent years, but high-performing ratiometric indicators are still rare. Here we describe a series of fluorescence resonance energy transfer (FRET)-based calci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58ee0e7e685b9bf3d74a37ef35fc2f2
https://pubmed.ncbi.nlm.nih.gov/24481218
https://pubmed.ncbi.nlm.nih.gov/24481218
Publikováno v:
Methods in cell biology. 113
Developing technologies now allow observing cellular motility and functions in the living animal. Here, we introduce the method of intravital imaging by using two-photon microscopy. To acquire images with good quality, a highly stablilized tissue is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59a95278fb9d999a08c6ca388fa36a50
https://pubmed.ncbi.nlm.nih.gov/23317902
https://pubmed.ncbi.nlm.nih.gov/23317902