Topical iontophoretic delivery of ionizable, biolabile aciclovir prodrugs: A rational approach to improve cutaneous bioavailability

Autor: Yong Chen, Ingo Alberti, Yogeshvar N. Kalia

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 99:103-113

The objective was to investigate the topical iontophoretic delivery of a series of amino acid ester prodrugs of aciclovir (ACV-X, where ACV=aciclovir and X=Arg, Gly, Ile, Phe, Trp and Val) as a means to enhance cutaneous delivery of ACV. The newly sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26fdff297d776908b213d8ad2de03e3
https://doi.org/10.1016/j.ejpb.2015.12.002

In vivo assessment of enhanced topical delivery of terbinafine to human stratum corneum

Autor: Richard H. Guy, Yogeshvar N. Kalia, Aarti Naik, Jean-Daniel Bonny, Ingo Alberti

Publikováno v: Journal of Controlled Release, Vol. 71, No 3 (2001) pp. 319-27

Purpose: The objective of this study was to evaluate, using attenuated total reflectance Fourier transform infrared spectroscopy, the stratum corneum (SC) bioavailability of terbinafine (TBF) following topical treatment with four different formulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1822b59812b88cd490458d6147e3ee4
https://doi.org/10.1016/s0168-3659(01)00244-9

Transdermal and Skin-Targeted Drug Delivery

Autor: Richard H. Guy, Yogeshvar N. Kalia, Virginia Merino, Ingo Alberti

Publikováno v: Journal of Cutaneous Medicine and Surgery, Vol. 2, No 2 (1997) pp. 108-119

Background: The application of therapeutic agents to the skin addresses three general objectives: (a) the treatment of a variety of dermatologic diseases; (b) the “targeted” delivery of drugs to deeper subcutaneous tissues, with a concomitant red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ce714d04828664ddda7a348f7307aa
https://doi.org/10.1177/120347549700200212

Next generation intra- and transdermal therapeutic systems: using non- and minimally-invasive technologies to increase drug delivery into and across the skin

Autor: Maria Lapteva, Ingo Alberti, Tais Gratieri, Yogeshvar N. Kalia

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 50(5)

The number of drug molecules approved by the regulatory authorities for transdermal administration is relatively modest - less than two dozen. Many other therapies might benefit from the advantages offered by the transdermal route. That they have not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1144f2b1fb42c44e421a2448e536b8d
https://pubmed.ncbi.nlm.nih.gov/23567467

In vivo methods for the assessment of topical drug bioavailability

Autor: François-Xavier Mathy, Véronique Préat, Yogeshvar N. Kalia, Christophe Herkenne, Ingo Alberti, Richard H. Guy, Aarti Naik

Publikováno v: Pharmaceutical Research, Vol. 25, no. 1, p. 87-103 (2008)
Herkenne, C, Alberti, I, Naik, A, Kalia, Y N, Mathy, F X, Préat, V & Guy, R H 2008, ' In vivo methods for the assessment of topical drug bioavailability ', Pharmaceutical Research, vol. 25, no. 1, pp. 87-103 . https://doi.org/10.1007/s11095-007-9429-7
Pharmaceutical Research
Pharmaceutical Research, Vol. 25, No 1 (2008) pp. 87-103

This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c82305e4e633569a11be5912170402
https://hdl.handle.net/2078.1/25817