Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ingmar B Schäfer"'
Autor:
Ksenia Finogenova, Jacques Bonnet, Simon Poepsel, Ingmar B Schäfer, Katja Finkl, Katharina Schmid, Claudia Litz, Mike Strauss, Christian Benda, Jürg Müller
Publikováno v:
eLife, Vol 9 (2020)
Repression of genes by Polycomb requires that PRC2 modifies their chromatin by trimethylating lysine 27 on histone H3 (H3K27me3). At transcriptionally active genes, di- and tri-methylated H3K36 inhibit PRC2. Here, the cryo-EM structure of PRC2 on din
Externí odkaz:
https://doaj.org/article/b56404b7d88d4c11888da6a19bb84f37
Autor:
Michael C. Lawrence, Carlie Delaine, Heidi L. Schubert, Allanah Merriman, Xiaochun Xiong, Ünal Coskun, Theresia Gutmann, Briony E. Forbes, Rahul Agrawal, Helena Safavi-Hemami, Alan Blakely, John G. Menting, Jin Hwan Kim, Christopher P. Hill, Gizem Artik, Yi Zhang, Simon J. Fisher, Danny Hung-Chieh Chou, Ingmar B. Schäfer
Cone snail venoms contain a wide variety of bioactive peptides, including insulin-like molecules with distinct structural features, binding modes, and biochemical properties. Here, we report a fully active humanized cone snail venom insulin with an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f22807bbb2352e33e6651bd89c5b6d0
https://doi.org/10.21203/rs.3.rs-501661/v1
https://doi.org/10.21203/rs.3.rs-501661/v1
Autor:
Xiaochun Xiong, Alan Blakely, Jin Hwan Kim, John G. Menting, Ingmar B. Schäfer, Heidi L. Schubert, Rahul Agrawal, Theresia Gutmann, Carlie Delaine, Yi Wolf Zhang, Gizem Olay Artik, Allanah Merriman, Debbie Eckert, Michael C. Lawrence, Ünal Coskun, Simon J. Fisher, Briony E. Forbes, Helena Safavi-Hemami, Christopher P. Hill, Danny Hung-Chieh Chou
Publikováno v:
Nat. Chem. Biol. 18, 511-519 (2022)
Cone snail venoms contain a wide variety of bioactive peptides, including insulin-like molecules with distinct structural features, binding modes and biochemical properties. Here, we report an active humanized cone snail venom insulin with an elongat
Autor:
Katja Finkl, Christian Benda, Claudia Litz, Mike Strauss, Ksenia Finogenova, Jürg Müller, Jacques Bonnet, Katharina Schmid, Ingmar B. Schäfer, Simon Poepsel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::269987359eb04526015cceea369d93d9
https://doi.org/10.7554/elife.61964.sa2
https://doi.org/10.7554/elife.61964.sa2
Publikováno v:
Molecular Cell
The superkiller (SKI) complex is the cytoplasmic co-factor and regulator of the RNA-degrading exosome. In human cells, the SKI complex functions mainly in co-translational surveillance-decay pathways, and its malfunction is linked to a severe congeni
Autor:
Chetan Poojari, Ünal Coskun, Beate Brankatschk, Ingmar B. Schäfer, Ilpo Vattulainen, Mike Strauss, Theresia Gutmann
Publikováno v:
J. Cell Biol. 219:e201907210 (2020)
The Journal of Cell Biology
The Journal of Cell Biology
The cryo-EM structure of the complete insulin receptor ectodomain saturated with four insulin ligands reveals a T-like conformation with converging membrane-proximal domains and structural evidence of insulin binding sites 2/2′.
Glucose homeos
Glucose homeos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c091316a35b14a353af8790cabf503
http://hdl.handle.net/10138/310454
http://hdl.handle.net/10138/310454
Centromeres are defined epigenetically by nucleosomes containing the histone H3 variant CENP-A, upon which the constitutive centromere-associated network of proteins (CCAN) is built. CENP-C, is considered to be a central organizer of the CCAN. We pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19df170e062f07e22132aab25a50bc60
https://doi.org/10.1101/705699
https://doi.org/10.1101/705699
Publikováno v:
EMBO Reports
EMBO REPORTS
EMBO REPORTS
Centromeres are defined epigenetically by nucleosomes containing the histone H3 variant CENP ‐A, upon which the constitutive centromere‐associated network of proteins (CCAN ) is built. CENP ‐C is considered to be a central organizer of the CCAN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf8c66bb4ee1fdae263329838e9032c
http://hdl.handle.net/10852/76232
http://hdl.handle.net/10852/76232
Autor:
Jan M. Schuller, Mike Strauss, Elena Conti, Ingmar B. Schäfer, Steffen Schüssler, Masami Yamashita, Peter Reichelt
Publikováno v:
Cell
Summary The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail. This poly(A) RNP not only protects mRNAs from premature degradation but also stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de720de8e6962aed455a732255c4406
https://hdl.handle.net/21.11116/0000-0003-E98D-821.11116/0000-0003-E98F-621.11116/0000-0003-E990-3
https://hdl.handle.net/21.11116/0000-0003-E98D-821.11116/0000-0003-E98F-621.11116/0000-0003-E990-3
Autor:
Christopher M. Sanderson, Andrew A. Peden, Helen M. Kent, J. Paul Luzio, Ingmar B. Schäfer, Sally R. Gray, David J. Owen, Philip R. Evans
Publikováno v:
Developmental Cell
Summary VAMP7 is involved in the fusion of late endocytic compartments with other membranes. One possible mechanism of VAMP7 delivery to these late compartments is via the AP3 trafficking adaptor. We show that the linker of the δ-adaptin subunit of