Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Inger Thorup"'
1
Evaluation of Cell Proliferation in Rat Mammary Glands Is Not Predictive of the Carcinogenic Potential of Insulin In Vivo
Autor: Anne-Marie Mølck, Ingrid Sjögren, Jette Nowak, Vivi F. H. Jensen, Inger Thorup, Peter R. Brinck
Publikováno v: International Journal of Toxicology. 39:560-576
For nonclinical safety-assessment of insulin analogues in vivo, mitogenic effects are compared to that of human insulin. Besides histopathologic evaluation, this usually includes assessment of cell proliferation (CP) in mammary glands. Insulin analog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a354a664c636addf55ba41b1319f3c0
https://doi.org/10.1177/1091581820941776
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2
The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model
Autor: Johannes Josef Fels, Henrik Søeborg, Inger Thorup, Mikala Skydsgaard, Lærke W. Andersen, Hanne Offenberg, Kevin A. Keane, Charlotte M. Dalsgaard, Ingrid Sjögren, Jennifer M. Rojas, Line Olrik Berthelsen, Jette Nowak, Florian Bolze, Jes Tovborg Jensen, Majken Dalgaard
Publikováno v: Toxicologic Pathology. 46:777-798
The obese rodent serves as an indispensable tool for proof-of-concept efficacy and mode-of-action pharmacology studies. Yet the utility of this disease model as an adjunct to the conventional healthy animal in the nonclinical safety evaluation of ant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720b22f18b55257c12209b4651c6fd5d
https://doi.org/10.1177/0192623318803557
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3
Cholecystokinin-1 receptor agonist induced pathological findings in the exocrine pancreas of non-human primates
Autor: Anne Sietske de Boer, David Wederkinck Andersen, Birgitte Schjellerup Wulff, Anne Bugge, Inger Thorup, Trine R. Clausen, Niels C. Berg Nyborg, Rikke Kaae Kirk
Publikováno v: Toxicology and Applied Pharmacology. 399:115035
Background and aims Cholecystokinin (CCK) may potentially be used to treat obesity. However, it is well-known to induce acute pancreatitis and pancreas neoplasia in rodents, but not in primates. Here we report the nonclinical safety profile of a long
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcc8df3b05823d60dcfb6ca23913b2a
https://doi.org/10.1016/j.taap.2020.115035
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4
The Human GLP-1 Analogs Liraglutide and Semaglutide: Absence of Histopathological Effects on the Pancreas in Nonhuman Primates
Autor: Carsten F. Gotfredsen, Marianne O. Larsen, Zaki Salanti, Lotte Bjerre Knudsen, Anne-Marie Mølck, Inger Thorup, Niels C. Berg Nyborg
Publikováno v: Diabetes. 63:2486-2497
Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight and histolo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2e0b4ff360dbfc2e250989915b260b
https://doi.org/10.2337/db13-1087
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5
The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis
Autor: Inger Thorup, Andres Eskjær Jensen, Niels Vrang, Henrik Søeborg, Lotte Simonsen, Lotte Bjerre Knudsen, Jacob Jelsing
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 303:E253-E264
A possible association between glucagon-like peptide-1 (GLP-1) analogs and incidences of pancreatitis has been suggested based on clinical studies. In male and female diabetic Zucker diabetic fatty (ZDF) rats, we investigated the effects of continuou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332805059f3a5c97845a6398b0f828f5
https://doi.org/10.1152/ajpendo.00182.2012
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6
Unique expression pattern of the three insulin receptor family members in the rat mammary gland: dominance of IGF-1R and IRR over the IR, and cyclical IGF-1R expression
Autor: Robert Klopfleisch, Martin B. Oleksiewicz, Henning Hvid, Henrik Jeldtoft Jensen, Inger Thorup, Sara G. Vienberg, Bo Falck Hansen
Publikováno v: Journal of Applied Toxicology. 31:312-328
Supra-pharmacological doses of the insulin analog X10 (AspB10) increased the incidence of mammary tumors in female Sprague-Dawley rats in chronic toxicity studies, most likely via receptor-mediated mechanisms. However, little is known about the expre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4357dc29d35cc17c3654679bf99b1526
https://doi.org/10.1002/jat.1627
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7
Prolonged effect of GlycoPEGylated rFVIIa (40k-PEG-rFVIIa) in rabbits correlates to activity in plasma
Autor: Mette B. Hermit, Henrik Agersø, Mikael Tranholm, Inger Thorup, Brit B. Sørensen, Mirella Ezban, Henning R. Stennicke, Peter B. Johansen, Søren E. Bjørn
Publikováno v: Thrombosis and Haemostasis. 104:157-164
SummaryThe pharmacokinetics and pharmacodynamics of 40k-PEG-rFVIIa, a GlycoPEGylated derivative of recombinant wild-type FVIIa, were compared with rFVIIa in rabbits. The procoagulant effect was determined as the weight of the clot formed in a defined
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee203d12d8fee4b1d344f1588763a1e6
https://doi.org/10.1160/th09-11-0797
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8
Generalized Cellular Hypertrophy is Induced by a Dual-Acting PPAR Agonist in Rat Urinary Bladder Urothelium In Vivo
Autor: Torben S. Guldberg, Peter R. Brinck, Inger Thorup, Anne Charlotte Hegelund, Marianne B. Jensen, Ulla K. Thinggaard, Ingrid Sjögren, Henriette S. Nielsen, Lars Fogh Iversen, Martin B. Oleksiewicz, Hanne V. Andersen, Lis Jørgensen
Publikováno v: Toxicologic Pathology. 33:552-560
Some developmental dual-acting PPARα/γ agonists, such as ragaglitazar, have shown carcinogenic effects in the rodent urinary bladder urothelium after months-years of dosing. We examined early (precancerous) changes in the bladder urothelium of rats
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c61986d6c55074d8bf062939d91022
https://doi.org/10.1080/01926230500214657
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9
Biomarkers for early effects of carcinogenic dual-acting PPAR agonists in rat urinary bladder urotheliumin vivo
Autor: Martin B. Oleksiewicz, Frederikke Lihme Egerod, Inger Thorup, T. Storgaard, Lars Fogh Iversen, Henriette S. Nielsen
Publikováno v: Biomarkers. 10:295-309
Small-molecule agonists of the peroxisome proliferator-activated receptor (PPAR) alpha and gamma isoforms (dual-acting PPAR agonists) can cause urothelial cancers in rodents. Rats were dosed orally for 16 days with bladder carcinogenic (ragaglitazar)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09768b3467ca0722b475c1db6a19b28
https://doi.org/10.1080/13547500500218682
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10
IQ (2-amino-3-methylimidazo[4,5-f]quinoline)-induced aberrant crypt foci and colorectal tumour development in rats fed two different carbohydrate diets
Autor: Inger Thorup, Otto A. Meyer, Anne-Marie Mølck, E. Kristiansen
Publikováno v: European Journal of Cancer Prevention. 10:501-506
In most aberrant crypt foci (ACF) and colorectal tumour studies, chemical carcinogens not normally found in food have been used as initiators. In the present study the food-related compound, IQ (2-amino-3-methyl-imidazo[4,5-f]quinoline), has been use
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3f9dc7a0f83d6f14e6320ba53b552c
https://doi.org/10.1097/00008469-200112000-00004
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