Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Inger Sandlie"'
Autor:
Stian Foss, Siri A. Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz, Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg, Simone Mester, Malin Bern, Mitchell Evers, Diane B. Bratlie, Terje E. Michaelsen, Tilman Schlothauer, Devin Sok, Jayanta Bhattacharya, Jeanette Leusen, Thomas Valerius, Sanjay Ram, Suzan H. M. Rooijakkers, Inger Sandlie, Jan Terje Andersen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dos
Externí odkaz:
https://doaj.org/article/e2bf31ade1774fb9ab1a7bfa70490845
Autor:
Torleif Tollefsrud Gjølberg, Rahel Frick, Simone Mester, Stian Foss, Algirdas Grevys, Lene Støkken Høydahl, Øystein Kalsnes Jørstad, Tilman Schlothauer, Inger Sandlie, Morten C. Moe, Jan Terje Andersen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Analysis of clinically approved antibody-based therapeutics reveals different structural designs, such as full-length IgG1 or Fc-fusions, entail distinct biophysical properties that affect FcRn binding, intracellular transport and plasma half-life.
Externí odkaz:
https://doaj.org/article/18d566ba3fec46aab3ecfa4b84b5d168
Autor:
Algirdas Grevys, Rahel Frick, Simone Mester, Karine Flem-Karlsen, Jeannette Nilsen, Stian Foss, Kine Marita Knudsen Sand, Thomas Emrich, Jens Andre Alexander Fischer, Victor Greiff, Inger Sandlie, Tilman Schlothauer, Jan Terje Andersen
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103746- (2022)
Summary: Monoclonal IgG antibodies are the fastest growing class of biologics, but large differences exist in their plasma half-life in humans. Thus, to design IgG antibodies with favorable pharmacokinetics, it is crucial to identify the determinants
Externí odkaz:
https://doaj.org/article/af03cd0842d240c99a1d1d9176bb39cf
Autor:
Simone Mester, Mitchell Evers, Saskia Meyer, Jeannette Nilsen, Victor Greiff, Inger Sandlie, Jeanette Leusen, Jan Terje Andersen
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin. A prerequisite for such design is t
Externí odkaz:
https://doaj.org/article/d68dea8700bb4629943b62d258a17e3a
Autor:
Algirdas Grevys, Jeannette Nilsen, Kine M. K. Sand, Muluneh B. Daba, Inger Øynebråten, Malin Bern, Martin B. McAdam, Stian Foss, Tilman Schlothauer, Terje E. Michaelsen, Gregory J. Christianson, Derry C. Roopenian, Richard S. Blumberg, Inger Sandlie, Jan Terje Andersen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The development of IgG and albumin-based therapeutics with increased half-lives needs more efficient screening procedures. Here the authors report a human endothelial cell-based recycling assay enabling screening of IgG and albumin variants without c
Externí odkaz:
https://doaj.org/article/99bc76e2016a473a870d99a7c561cd47
Autor:
Stian Foss, Maria Bottermann, Alexandra Jonsson, Inger Sandlie, Leo C. James, Jan Terje Andersen
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Tripartite motif containing-21 (TRIM21) is a cytosolic ubiquitin ligase and antibody receptor that provides a last line of defense against invading viruses. It does so by acting as a sensor that intercepts antibody-coated viruses that have evaded ext
Externí odkaz:
https://doaj.org/article/2f798ba3b63b4ce58034b1b7c811ebfc
Autor:
Michal Pyzik, Kine M. K. Sand, Jonathan J. Hubbard, Jan Terje Andersen, Inger Sandlie, Richard S. Blumberg
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids. Although IgG alone can directly protect the body from infection through the
Externí odkaz:
https://doaj.org/article/27e7fa5563db47e0ae8292d94df0547e
Autor:
Kristin Støen Gunnarsen, Lene Støkken Høydahl, Ralf Stefan Neumann, Kaare Bjerregaard-Andersen, Nicolay Rustad Nilssen, Ludvig Magne Sollid, Inger Sandlie, Geir Åge Løset
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195868 (2018)
There is a quest for production of soluble protein of high quality for the study of T-cell receptors (TCRs), but expression often results in low yields of functional molecules. In this study, we used an E. coli chaperone-assisted periplasmic producti
Externí odkaz:
https://doaj.org/article/b5086d7c6cb54c909df8d7002f6c776b
Publikováno v:
Antibodies, Vol 8, Iss 2, p 32 (2019)
Monoclonal antibodies (mAbs) are valuable as research reagents, in diagnosis and in therapy. Their high specificity, the ease in production, favorable biophysical properties and the opportunity to engineer different properties make mAbs a versatile c
Externí odkaz:
https://doaj.org/article/b96e330fee174b9cb1c086573c4de7fe
Publikováno v:
BioTechniques, Vol 44, Iss 4, Pp 551-554 (2008)
Phage display holds a key position in the use of combinatorial library approaches for the purpose of protein engineering and discovery. However, modifying the pIII protein of the phage can severely and negatively influence the infectiousness of the p
Externí odkaz:
https://doaj.org/article/a0fd3f7a685f405a982b28c9d410115b