Zobrazeno 1 - 10
of 998
pro vyhledávání: '"Ingenuity Pathway Analysis"'
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Lung cancer is the second most common cancer with the highest mortality in the world. Calumenin as a molecular chaperone that not only binds various proteins within the endoplasmic reticulum but also plays crucial roles in diverse
Externí odkaz:
https://doaj.org/article/a312498234b9490f864c4aaf73145400
Autor:
Cameron Church, Christian X. Fay, Emil Kriukov, Hui Liu, Ashley Cannon, Lauren Ashley Baldwin, David K. Crossman, Bruce Korf, Margaret R. Wallace, Andrea M. Gross, Brigitte C. Widemann, Robert A. Kesterson, Petr Baranov, Deeann Wallis
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Neurofibromatosis Type 1 (NF1) is caused by loss of function variants in the NF1 gene. Most patients with NF1 develop skin lesions called cutaneous neurofibromas (cNFs). Currently the only approved therapeutic for NF1 is selumetinib, a mitog
Externí odkaz:
https://doaj.org/article/d00a5353dd604d0dbaf40783a4391f24
Autor:
Abdulwahab Noorwali, Fadwa Aljoud, Amani Alghamdi, Noora Sattami, Taghreed Bashah, Abdulsalam Noorwali, Peter Natesan Pushparaj, Kalamegam Gauthaman
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39940- (2024)
Background: Osteoarthritis (OA) is a prevalent joint disorder characterized by joint pain, functional impairment, and disability. The current study investigated the therapeutic effects of intra-articular injection of rat bone marrow-derived mesenchym
Externí odkaz:
https://doaj.org/article/37c709e0c4ff4e2eb2664a37708ff7fa
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundSenescence-accelerated mouse prone 8 (SAMP8) and age-matched SAMR1 mice are used to study the pathogenesis and therapeutics of Alzheimer’s disease (AD); however, the molecular mechanisms are not completely understood.ObjectiveThis study a
Externí odkaz:
https://doaj.org/article/0f28bf38c3e24ef6a9311d06c955bc64
Autor:
Mitsunori Yoshida, Andrew Taejun Kwon, Xian-Yang Qin, Hajime Nishimura, Shiori Maeda, Yuji Miyamoto, Yasuhiro Yoshida, Yoshihiko Hoshino, Harukazu Suzuki
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Mycobacterium avium complex (MAC) is a non-tuberculous mycobacterium widely distributed in the environment. Even though MAC infection is increasing in older women and immunocompromised patients, to our knowledge there has been no comprehensive analys
Externí odkaz:
https://doaj.org/article/9cccf859784c4b5e801c6070707c53dc
Autor:
Janina Pearce, Caitlin Durr, Xufeng Qu, Jinze Liu, Leslie Randall, Devin Miller, Sadia Sayeed, Victoria Bae-Jump, Stephanie Sullivan
Publikováno v:
Gynecologic Oncology Reports, Vol 52, Iss , Pp 101360- (2024)
Objective: Endometrial cancer (EC) incidence and mortality are increasing with striking racial disparities. Race and obesity are known risk factors for EC, however, their relationship and impact on tumor biology in higher grade endometrioid EC are un
Externí odkaz:
https://doaj.org/article/470c11da6866428aa530153c10b7eb16
Publikováno v:
Middle East Fertility Society Journal, Vol 28, Iss 1, Pp 1-16 (2023)
Abstract Background Parkinson’s disease (PD) is a neurodegenerative condition that is characterized by a progressive decline of neural pathways, and its pathology is associated with alpha-synuclein abnormalities. Currently, infertility affects abou
Externí odkaz:
https://doaj.org/article/e2b3cf8a37ce4d40af97d239df160303
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 6, Pp n/a-n/a (2023)
Abstract We previously reported that sodium pentobarbital inhibited the growth of the breast cancer associated with the normalization of microcirculatory hemodynamics and oxygenation. Here, we aimed to screen the key regulatory proteins involved in p
Externí odkaz:
https://doaj.org/article/66206106d46f4553b4cfa2a305e58805
Autor:
Firoz Ahmed
Publikováno v:
AIMS Bioengineering, Vol 10, Iss 2, Pp 111-140 (2023)
Type 2 diabetes (T2D) is a major global health problem often caused by the inability of pancreatic islets to compensate for the high insulin demand due to apoptosis. However, the complex mechanisms underlying the activation of apoptosis and its count
Externí odkaz:
https://doaj.org/article/a227e5877f7c4d87b47d3392b1ca7f8f
Autor:
Hajime Nakamura, Megumi Watanabe, Kohichi Takada, Tatsuya Sato, Fumihito Hikage, Araya Umetsu, Joji Muramatsu, Masato Furuhashi, Hiroshi Ohguro
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1011 (2024)
To elucidate the currently unknown molecular mechanisms responsible for the similarity and difference during the acquirement of resistance against gemcitabine (GEM) and paclitaxel (PTX) in patients with pancreatic carcinoma, we examined two-dimension
Externí odkaz:
https://doaj.org/article/5a9bb5f575f542c9bb1f971bdb0e4e6f