Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Ingemar Jacobson"'
Autor:
Annika Åstrand, Monika Sundqvist, Maria Thorstensson, Tomas Fex, Andreas Nordin, Ahlke Hayen, Annika Björe, Ulrik Gran, Christina Olsson, Johan Sundell, Elin Forsström, Emma Lindhardt, Jonas Boström, Gunilla Linhardt, Teresa Collins, Boel Löfberg, Fanyi Jiang, Roine I. Olsson, Ingemar Jacobson, Anna Öhrn, Karolina Aplander, Olle Hidestål, Jonna Gyll
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:706-710
Diphenylphosphinic amides and diphenylphosphine oxides have been synthesized and tested as inhibitors of the Kv1.5 potassium ion channel as a possible treatment for atrial fibrillation. In vitro structure-activity relationships are discussed and seve
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 63:40-46
Accumulating evidence suggest that drug-induced QT prolongation per se poorly predicts repolarisation-related proarrhythmia liability. We examined whether beat-by-beat variability of the QT interval may be a complementary proarrhythmia marker to QT p
Publikováno v:
Biophysical Journal. 99(9):2726-2736
A wide range of ion channels have been considered as potential targets for pharmacological treatment of atrial fibrillation. The Kv1.5 channel, carrying the IKur current, has received special attention because it contributes to repolarization in the
Publikováno v:
Trends in Pharmacological Sciences. 31:364-371
Atrial fibrillation (AF) is an arrhythmia of growing clinical concern that is increasing in prevalence and is associated with significant morbidity and mortality. Pharmacological agents remain the first-line therapy for the AF patient, and the potent
Publikováno v:
Journal of Cardiovascular Pharmacology. 46:7-17
AZD7009 is a novel antiarrhythmic compound in early clinical development for management of atrial fibrillation. Electrophysiological studies in animals have shown high antiarrhythmic efficacy, predominant action on atrial electrophysiology, and low p
Autor:
Annika Åstrand, Anna Rönnborg, Emma Lindhardt, Ulrik Gran, Gert Strandlund, Hans Emtenäs, Zhong-Qing Yuan, Jonas Boström, Johan Sundell, Jonna Gyll, Ågot Högberg, Boel Löfberg, Tommy Iliefski, Roine I. Olsson, Birgit Andersson, Olle Hidestål, Tor Svensson, Ingemar Jacobson, Elin Forsström, Frida Persson, Christina Olsson, Annika Björe, Gunilla Linhardt, Öjvind Davidsson, Ola Fjellström, Jesper Malmberg
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(5)
A series of lactam sulfonamides has been discovered and optimized as inhibitors of the Kv1.5 potassium ion channel for treatment of atrial fibrillation. In vitro structure–activity relationships from lead structure C to optimized structure 3y are d
Publikováno v:
Anatomy and Embryology. 200:541-549
The mucosa of the esophagus consists of stratified squamous epithelium that has a considerable resistance to injury. Intercellular glycoconjugates appear to constitute a major permeability barrier in the superficial portion of the esophageal mucosa.
Publikováno v:
Analytical Chemistry. 70:2468-2474
We present a capillary electrophoresis-patch clamp detection system optimized for screening of antagonists and inhibitors of ligand-gated ion channels. In this system, highly selective receptor agonists are delivered through the electrophoresis capil
Autor:
Ann-Kristin Nordkam, Malin Florentzson, Leif Carlsson, Annika Åstrand, Ingemar Jacobson, Emma Lindhardt, Gunilla Linhardt, Göran Duker
Publikováno v:
Journal of cardiovascular pharmacology and therapeutics. 18(3)
Objective: To examine the electrophysiological, hemodynamic, and antiarrhythmic effects of the novel antiarrhythmic agent AZ13395438. Methods: The ion channel-blocking potency of AZ13395438 was assessed in Chinese hamster ovary cells stably expressin
Autor:
Alexander Moscho, Owe Orwar, Richard H. Scheller, Kent Jardemark, Harvey A. Fishman, Richard N. Zare, Ingemar Jacobson
Publikováno v:
Science. 272:1779-1782
Gamma-aminobutyrate acid, L-glutamate, and N-methyl-D-aspartate were separated by capillary electrophoresis and detected by the use of whole-cell and outside-out patch-clamp techniques on freshly dissociated rat olfactory interneurons. These neuroact