Zobrazeno 1 - 10
of 605
pro vyhledávání: '"Ingemar, Björkhem"'
Autor:
Anna Sandebring-Matton, Julen Goikolea, Ingemar Björkhem, Laura Paternain, Nina Kemppainen, Tiina Laatikainen, Tiia Ngandu, Juha Rinne, Hilkka Soininen, Angel Cedazo-Minguez, Alina Solomon, Miia Kivipelto
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Background 27-Hydroxycholesterol (27-OH), the main circulating oxysterol in humans and the potential missing link between peripheral hypercholesterolemia and Alzheimer’s disease (AD), has not been investigated previously in relation to cog
Externí odkaz:
https://doaj.org/article/331e6ffc2e9744dcabc5a657dfe423ad
Autor:
Anne Kristine G. Hansen, Trond M. Kortner, Aleksei Krasnov, Ingemar Björkhem, Michael Penn, Åshild Krogdahl
Publikováno v:
BMC Veterinary Research, Vol 16, Iss 1, Pp 1-15 (2020)
Abstract Background Various intestinal morphological alterations have been reported in cultured fish fed diets with high contents of plant ingredients. Since 2000, salmon farmers have reported symptoms indicating an intestinal problem, which we sugge
Externí odkaz:
https://doaj.org/article/28c8eac84e6f417180dff4c151ca6852
Autor:
Stefan Hauser, Marion Poenisch, Yvonne Schelling, Philip Höflinger, Stefanie Schuster, Axel Teegler, Rabea Betten, Jan-Åke Gustafsson, Jeannette Hübener-Schmid, Thomas Schlake, Frédéric Chevessier-Tünnesen, Nigel Horscroft, Ingemar Björkhem, Ludger Schöls
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 359-370 (2019)
Hereditary spastic paraplegia type 5 is a neurodegenerative disease caused by loss-of-function mutations in the CYP7B1 gene encoding the oxysterol 7-α-hydroxylase involved in bile acid synthesis in the liver. Lack of CYP7B1 leads to an accumulation
Externí odkaz:
https://doaj.org/article/4aeaa97d4bae48d099f191ccf0272017
Autor:
Emanuele Porru, Erik Edström, Lisa Arvidsson, Adrian Elmi-Terander, Alexander Fletcher-Sandersjöö, Anita Lövgren Sandblom, Magnus Hansson, Frida Duell, Ingemar Björkhem
Publikováno v:
Brain Sciences, Vol 12, Iss 11, p 1450 (2022)
Idiopathic normal pressure hydrocephalus (iNPH) is the most common form of hydrocephalus in the adult population, and is often treated with cerebrospinal fluid (CSF) drainage using a ventriculoperitoneal (VP) shunt. Symptoms of iNPH include gait impa
Externí odkaz:
https://doaj.org/article/61c367d9fb9949ba8ba68eaec67e7e71
Autor:
Vilma Alanko, Adhara Gaminde‐Blasco, Tania Quintela‐López, Raúl Loera‐Valencia, Alina Solomon, Ingemar Björkhem, Angel Cedazo‐Minguez, Silvia Maioli, Graziella Tabacaru, María Latorre‐Leal, Carlos Matute, Miia Kivipelto, Elena Alberdi, Anna Sandebring‐Matton
Publikováno v:
Glia. 71:1414-1428
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf749767c89e96ac7d960d2955368c73
https://doi.org/10.1002/glia.24348
https://doi.org/10.1002/glia.24348
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 2, Pp 455-459 (2017)
We confirmed previous findings by a Japanese group that there is an accumulation of 7α-hydroxy-3-oxo-4-cholestenoic acid (7-Hoca) in human subdural hematomas. The accumulation correlated with the time from the bleeding to the sample collection. We p
Externí odkaz:
https://doaj.org/article/b9a3f79858e14db88ea92533aa574d91
Autor:
Joseph B. Lin, Natalia Mast, Ilya R. Bederman, Yong Li, Henri Brunengraber, Ingemar Björkhem, Irina A. Pikuleva
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 2, Pp 258-264 (2016)
The retina, a thin tissue in the back of the eye, has two apparent sources of cholesterol: in situ biosynthesis and cholesterol available from the systemic circulation. The quantitative contributions of these two cholesterol sources to the retinal ch
Externí odkaz:
https://doaj.org/article/db2d8be25a3c4a7ba7e0fe00491891c1
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
24S-hydroxycholesterol (24OHC) and Tau are produced in neuronal cells and neurodegeneration leads to increased flux of both of them into cerebrospinal fluid (CSF). In the present study, CSF levels of 24OHC and 27S-hydroxycholesterol (27OHC) along wit
Externí odkaz:
https://doaj.org/article/4b7e02575f6344cab47abe59ea18e28d
Autor:
Ingemar Björkhem, Ulf Diczfalusy, Anita Lövgren-Sandblom, Lena Starck, Monica Jonsson, Keri Tallman, Henrik Schirmer, Lilian Bomme Ousager, Peter J. Crick, Yuqin Wang, William J. Griffiths, F. Peter Guengerich
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 6, Pp 1165-1172 (2014)
A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product. Some patients with cereb
Externí odkaz:
https://doaj.org/article/576e66e606e24d37898877f880a7b361
Autor:
Ahmed Saeed, Federico Floris, Ulla Andersson, Irina Pikuleva, Anita Lövgren-Sandblom, Maria Bjerke, Martin Paucar, Anders Wallin, Per Svenningsson, Ingemar Björkhem
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 2, Pp 313-318 (2014)
There is a continuous flux of the oxysterol 27-hydroxycholesterol (27-OHC) from the circulation across the blood-brain barrier (BBB) into the brain. The major metabolite of 27-OHC in the brain is 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA). We con
Externí odkaz:
https://doaj.org/article/59a7314806d24d4a9fc206a8a02a6f57