Výsledky vyhledávání - "Ingela Ahlstedt"

Akademický článek

Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts

Autor: Martin Uhrbom, Lars Muhl, Guillem Genové, Jianping Liu, Henrik Palmgren, Ida Alexandersson, Fredrik Karlsson, Alex-Xianghua Zhou, Sandra Lunnerdal, Sonja Gustafsson, Byambajav Buyandelger, Kasparas Petkevicius, Ingela Ahlstedt, Daniel Karlsson, Leif Aasehaug, Liqun He, Marie Jeansson, Christer Betsholtz, Xiao-Rong Peng

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Cell identities are defined by intrinsic transcriptional networks and spatio-temporal environmental factors. Here, we explored multiple factors that contribute to the identity of adipose stem cells, including anatomic location, microvascular

Externí odkaz: https://doaj.org/article/1b79a0f896454151b3ae472ae9fc9feb

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Akademický článek

TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

The regulation of cellular phosphatidylethanolamine (PE) acyl chain composition is poorly understood. Here, the authors show that TLCD1 and TLCD2 proteins mediate the formation of monounsaturated fatty acid-containing PE species and promote the progr

Externí odkaz: https://doaj.org/article/15464563b39b4d54986a8c040d9d92b8

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Akademický článek

FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis

Autor: Cong Liu, Milena Schönke, Borah Spoorenberg, Joost M Lambooij, Hendrik JP van der Zande, Enchen Zhou, Maarten E Tushuizen, Anne-Christine Andreasson, Andrew Park, Stephanie Oldham, Martin Uhrbom, Ingela Ahlstedt, Yasuhiro Ikeda, Kristina Wallenius, Xiao-Rong Peng, Bruno Guigas, Mariëtte R Boon, Yanan Wang, Patrick CN Rensen

Publikováno v: eLife, Vol 12 (2023)

Analogues of the hepatokine fibroblast growth factor 21 (FGF21) are in clinical development for type 2 diabetes and nonalcoholic steatohepatitis (NASH) treatment. Although their glucose-lowering and insulin-sensitizing effects have been largely unrav

Externí odkaz: https://doaj.org/article/10b3762987d94deeac6dedce6336b7ac

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Akademický článek

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Publikováno v: Molecular Metabolism, Vol 22, Iss , Pp 49-61 (2019)

Objective: Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of advanced chronic liver disease. The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributo

Externí odkaz: https://doaj.org/article/f77b71978d104e8aa87a52faaeaa4522

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Akademický článek

Modeling human pancreatic beta cell dedifferentiation

Autor: Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann

Publikováno v: Molecular Metabolism, Vol 10, Iss , Pp 74-86 (2018)

Objective: Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Methods: Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pa

Externí odkaz: https://doaj.org/article/68b32ae0380845d7a7bc838551e3e8a7

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Akademický článek

Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.

Autor: Christopher J Lelliott, Andrea Ahnmark, Therese Admyre, Ingela Ahlstedt, Lorraine Irving, Feenagh Keyes, Laurel Patterson, Michael B Mumphrey, Mikael Bjursell, Tracy Gorman, Mohammad Bohlooly-Y, Andrew Buchanan, Paula Harrison, Tristan Vaughan, Hans-Rudolf Berthoud, Daniel Lindén

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e112109 (2014)

We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose c

Externí odkaz: https://doaj.org/article/b7aa8b820e4f483cb303314c37c5602a

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Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells

Autor: Sven Göpel, Morten Gram Pedersen, Ingela Ahlstedt, Mickaël F. El Hachmane

Publikováno v: Scientific Reports

Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an important factor during development of diabetes. However, regulation of glucagon secretion is poor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d6d7cec13b58aaecd775a1142c2bd1

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