Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ingeborg B, Hooijkaas"'
Autor:
Jan Hendrik van Weerd, Rajiv A Mohan, Karel van Duijvenboden, Ingeborg B Hooijkaas, Vincent Wakker, Bastiaan J Boukens, Phil Barnett, Vincent M Christoffels
Publikováno v:
eLife, Vol 9 (2020)
Genome-wide association studies have implicated common genomic variants in the gene desert upstream of TBX3 in cardiac conduction velocity. Whether these noncoding variants affect expression of TBX3 or neighboring genes and how they affect cardiac co
Externí odkaz:
https://doaj.org/article/46aaf9b6deb8477aad93b64460517e7b
Autor:
Marie Günthel, Karel van Duijvenboden, Dennis E. M. de Bakker, Ingeborg B. Hooijkaas, Jeroen Bakkers, Phil Barnett, Vincent M. Christoffels
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 11, p 134 (2021)
Myocardial infarction causes ventricular muscle loss and formation of scar tissue. The surviving myocardium in the border zone, located adjacent to the infarct, undergoes profound changes in function, structure and composition. How and to what extent
Externí odkaz:
https://doaj.org/article/e52b4995265f4ae59569e0a64eefa134
Autor:
Malou van den Boogaard, Jan Hendrik van Weerd, Amira C. Bawazeer, Ingeborg B. Hooijkaas, Harmen J.G. van de Werken, Federico Tessadori, Wouter de Laat, Phil Barnett, Jeroen Bakkers, Vincent M. Christoffels
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2704-2714.e5 (2019)
Summary: The human ether-a-go-go-related gene KCNH2 encodes the voltage-gated potassium channel underlying IKr, a current critical for the repolarization phase of the cardiac action potential. Mutations in KCNH2 that cause a reduction of the repolari
Externí odkaz:
https://doaj.org/article/f23e46c627da422ab766f3b9dde3a0a8
Autor:
Lejla Medzikovic, Hylja Heese, Pieter B. van Loenen, Cindy P. A. A. van Roomen, Ingeborg B. Hooijkaas, Vincent M. Christoffels, Esther E. Creemers, Carlie J. M. de Vries, Vivian de Waard
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1600 (2021)
Fibrosis is a hallmark of adverse cardiac remodeling, which promotes heart failure, but it is also an essential repair mechanism to prevent cardiac rupture, signifying the importance of appropriate regulation of this process. In the remodeling heart,
Externí odkaz:
https://doaj.org/article/39513847d0d6451e869bd58e23897a43
Autor:
Ingeborg B. Hooijkaas, Gerard J.J. Boink, Phil Barnett, Vincent Wakker, Jan Hendrik van Weerd, Mathilda T.M. Mommersteeg, Karel van Duijvenboden, Rajiv A Mohan, Jeroen Bakkers, Jianan Wang, Fernanda M Bosada, Bas J. Boukens, Ruben Coronel, Corrie de Gier-de Vries, Vincent M. Christoffels
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18617-18626. National Academy of Sciences
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18617-18626. National Academy of Sciences
Proc Natl Acad Sci U S A
Genome-wide association studies have identified noncoding variants near TBX3 that are associated with PR interval and QRS duration, suggesting that subtle changes in TBX3 expression affect atrioventricular conduction system function. To explore wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8663cd23b81fb29e373e075da220d7c
https://doi.org/10.1073/pnas.1919379117
https://doi.org/10.1073/pnas.1919379117
Autor:
Vincent M. Christoffels, James F. Martin, Ingeborg B. Hooijkaas, Jeroen Bakkers, Petra van der Kraak, Dennis E. M. de Bakker, Rob Janssen, Matthew C. Hill, Phil Barnett, Karel van Duijvenboden, Esther E. Creemers, Marie Günthel, Ingeborg van der Made, Joyce C K Man, Aryan Vink
Publikováno v:
Circulation, 140(10), 864-879. Lippincott Williams and Wilkins
Circulation, 140(10), 864-879. Lippincott Williams & Wilkins
Circulation, 140(10), 864-879. Lippincott Williams & Wilkins
Background: Surviving cells in the postinfarction border zone are subjected to intense fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been specifically implicated in cardiac regeneration. Here, we defined their uniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc5ca3766b718ac09d3a301b5b9e8d3
https://doi.org/10.1161/circulationaha.118.038944
https://doi.org/10.1161/circulationaha.118.038944
Autor:
Vincent M. Christoffels, Cindy P. A. A. van Roomen, Esther E. Creemers, Ingeborg B. Hooijkaas, Hylja Heese, Lejla Medzikovic, Vivian de Waard, Pieter B. van Loenen, Carlie J.M. de Vries
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1600, p 1600 (2021)
International journal of molecular sciences, 22(4):1600, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 4
International journal of molecular sciences, 22(4):1600, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 4
Fibrosis is a hallmark of adverse cardiac remodeling, which promotes heart failure, but it is also an essential repair mechanism to prevent cardiac rupture, signifying the importance of appropriate regulation of this process. In the remodeling heart,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12eb506173a64890e4cbc9c10f583829
https://www.mdpi.com/1422-0067/22/4/1600
https://www.mdpi.com/1422-0067/22/4/1600
Autor:
Joyce C K, Man, Karel, van Duijvenboden, Peter H L, Krijger, Ingeborg B, Hooijkaas, Ingeborg, van der Made, Corrie, de Gier-de Vries, Vincent, Wakker, Esther E, Creemers, Wouter, de Laat, Bastiaan J, Boukens, Vincent M, Christoffels
Publikováno v:
Circ Res
ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by the clustered genesTo explore the physiological functions of the enhancer cluster and elucidate the genomic mechanism underlyingBy analyzing epigenetic data we uncovere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::122f4e3901c11ca0942167cfeb96a916
https://pubmed.ncbi.nlm.nih.gov/33411631
https://pubmed.ncbi.nlm.nih.gov/33411631
Autor:
Esther E. Creemers, Vincent Wakker, Peter Hl L. Krijger, Corrie de Gier-de Vries, Vincent M. Christoffels, Wouter de Laat, Karel van Duijvenboden, Ingeborg van der Made, Joyce C K Man, Ingeborg B. Hooijkaas, Bastiaan J. Boukens
Publikováno v:
Circulation Research. Lippincott Williams & Wilkins
Circulation research, 128(1), 115-129. Lippincott Williams and Wilkins
Circulation research, 128(1), 115-129. Lippincott Williams and Wilkins
Rationale: ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by the clustered genes Nppa and Nppb , are important prognostic, diagnostic, and therapeutic proteins in cardiac disease. The spatiotemporal expression pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37936b5a1f3302d084c41fe5d2b55d99
https://hdl.handle.net/20.500.11755/5685a467-2801-4c42-a862-99219d10c9b8
https://hdl.handle.net/20.500.11755/5685a467-2801-4c42-a862-99219d10c9b8
Autor:
Brian L. Black, Karel van Duijvenboden, Stephanie Protze, Michael D. Wilson, Corrie de Gier-de Vries, Rajiv A Mohan, Vincent W. W. van Eif, Arie O. Verkerk, Fernanda M Bosada, Tanvi Sinha, Ian C. Scott, Auriane C. Ernault, Jeroen Bakkers, Xuefei Yuan, Vincent Wakker, Bastiaan J. Boukens, Ingeborg B. Hooijkaas, Vincent M. Christoffels
Publikováno v:
Circ Res
Circulation Research, 127(12), 1522-1535. Lippincott Williams & Wilkins
Circulation research, 127(12), 1522-1535. Lippincott Williams and Wilkins
Circulation Research
Circulation Research, American Heart Association, 2020, 127 (12), pp.1522-1535. ⟨10.1161/CIRCRESAHA.120.317054⟩
Circulation Research, 127(12), 1522-1535. Lippincott Williams & Wilkins
Circulation research, 127(12), 1522-1535. Lippincott Williams and Wilkins
Circulation Research
Circulation Research, American Heart Association, 2020, 127 (12), pp.1522-1535. ⟨10.1161/CIRCRESAHA.120.317054⟩
Rationale: The development and function of the pacemaker cardiomyocytes of the sinoatrial node (SAN), the leading pacemaker of the heart, are tightly controlled by a conserved network of transcription factors, including TBX3 (T-box transcription fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71635892586d118c861bf7fd7d94417
https://europepmc.org/articles/PMC8153223/
https://europepmc.org/articles/PMC8153223/
