Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Inge van der Werf"'
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Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells
Autor: Inge van der Werf, Phoebe K. Mondala, S. Kathleen Steel, Larisa Balaian, Luisa Ladel, Cayla N. Mason, Raymond H. Diep, Jessica Pham, Jacqueline Cloos, Gertjan J.L. Kaspers, Warren C. Chan, Adam Mark, James J. La Clair, Peggy Wentworth, Kathleen M. Fisch, Leslie A. Crews, Thomas C. Whisenant, Michael D. Burkart, Mary E. Donohoe, Catriona H.M. Jamieson
Publikováno v: Cell reports. Medicine, vol 4, iss 3
Cell reports. Medicine, 4(3):100962. Cell Press
Cell Reports Medicine, 4(3):100962. Cell Press
van der Werf, I, Mondala, P K, Steel, S K, Balaian, L, Ladel, L, Mason, C N, Diep, R H, Pham, J, Cloos, J, Kaspers, G J L, Chan, W C, Mark, A, la Clair, J J, Wentworth, P, Fisch, K M, Crews, L A, Whisenant, T C, Burkart, M D, Donohoe, M E & Jamieson, C H M 2023, ' Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells ', Cell reports. Medicine, vol. 4, no. 3, 100962, pp. 100962 . https://doi.org/10.1016/j.xcrm.2023.100962, https://doi.org/10.1016/j.xcrm.2023.100962
Pediatric acute myeloid leukemia (pAML) is typified by high relapse rates and a relative paucity of somatic DNA mutations. Although seminal studies show that splicing factor mutations and mis-splicing fuel therapy-resistant leukemia stem cell (LSC) g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635fc2f87ba6c7bb45c6b2245e0c70ae
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150286973&origin=inward
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5
Splicing factor gene mutations in acute myeloid leukemia offer additive value if incorporated in current risk classification
Autor: Manja Meggendorfer, Torsten Haferlach, Martijn W. Heymans, Anna Wojtuszkiewicz, Stephan Hutter, Inge van der Werf, Peter J. M. Valk, Jeroen Janssen, Wolfgang Kern, Constance Baer, Claudia Haferlach, Gert J. Ossenkoppele, Jacqueline Cloos
Publikováno v: van der Werf, I, Wojtuszkiewicz, A, Meggendorfer, M, Hutter, S, Baer, C, Heymans, M, Valk, P J M, Kern, W, Haferlach, C, Janssen, J J W M, Ossenkoppele, G J, Cloos, J & Haferlach, T 2021, ' Splicing factor gene mutations in acute myeloid leukemia offer additive value if incorporated in current risk classification ', Blood, vol. 5, no. 17, pp. 3254-3265 . https://doi.org/10.1182/BLOODADVANCES.2021004556
Blood advances, 5(17), 3254-3265. American Society of Hematology
Blood Adv
Blood, 5(17), 3254-3265. American Society of Hematology
Splicing factor (SF) mutations are important contributors to the pathogenesis of hematological malignancies; however, their relevance in risk classification of acute myeloid leukemia (AML) warrants further investigation. To gain more insight into the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b931cbfeb92bbcc17c321c20398001
https://doi.org/10.1182/bloodadvances.2021004556
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6
SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia
Autor: Gerrit Jansen, Inge van der Werf, Stephan Hutter, Richard W.J. Groen, Manja Meggendorfer, Torsten Haferlach, Claudia Haferlach, Jacqueline Cloos, Wencke Walter, Jeroen Janssen, Wolfgang Kern, Rocco Sciarrillo, Gertjan J.L. Kaspers, Gert J. Ossenkoppele, Huilan Yao, Anna Wojtuszkiewicz
Publikováno v: Leukemia
van der Werf, I, Wojtuszkiewicz, A, Yao, H, Sciarrillo, R, Meggendorfer, M, Hutter, S, Walter, W, Janssen, J, Kern, W, Haferlach, C, Haferlach, T, Jansen, G, Kaspers, G J L, Groen, R, Ossenkoppele, G & Cloos, J 2021, ' SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia ', Leukemia, vol. 35, no. 9, pp. 2698-2702 . https://doi.org/10.1038/s41375-021-01273-7
Leukemia, 35(9), 2698-2702. Nature Publishing Group
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2f2344a2058417f639d2e1f5215bfc
https://doi.org/10.1038/s41375-021-01273-7
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10
Deregulation of Splicing in Pediatric Acute Myeloid Stem and Progenitor Cells
Autor: Cayla Mason, Phoebe Mondala, Inge van der Werf, Ruben van Boxtel, Markus J van Roosmalen, Kathleen M. Fisch, Jacqueline Cloos, Adam Mark, Raymond Diep, Larisa Balaian, James J. La Clair, Leslie Crews, Gertjan J.L. Kaspers, Luisa Ladel, Catriona Jamieson, Warren C. W. Chan, Kathleen Steel, Thomas Whisenant, Peggy Wentworth, Mary Donohoe, Michael D. Burkart
Publikováno v: Mondala, P, Van Der Werf, I, Balaian, L, Steel, K, Ladel, L, Mason, C, Diep, R, Cloos, J, Kaspers, G, van Roosmalen, M J, Van Boxtel, R, Chan, W, Mark, A, Donohoe, M, La Clair, J, Wentworth, P, Fisch, K, Crews, L A, Whisenant, T, Burkart, M & Jamieson, C 2021, ' Deregulation of Splicing in Pediatric Acute Myeloid Stem and Progenitor Cells ', Blood, vol. 138 . https://doi.org/10.1182/blood-2021-154120
Blood, 138. American Society of Hematology
Currently, the limited capacity of pediatric acute myeloid leukemia (AML) therapies to prevent recurrence has contributed to high mortality rates. While dormant self-renewing leukemia stem cells (LSCs) contribute to adult AML relapse, their role in p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d410fc7237fa86fcd9dbbeb5e49ba660
https://doi.org/10.1182/blood-2021-154120
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