Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Inge S. Zuhorn"'
Autor:
Bhagyashree S. Joshi, Inge S. Zuhorn
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102134- (2023)
Summary: Here, we present a protocol using genetic engineering techniques to prepare small extracellular vesicles (sEVs) enriched in the chaperone protein DNAJB6. We describe steps to prepare cell lines overexpressing DNAJB6, followed by the isolatio
Externí odkaz:
https://doaj.org/article/ac884dc55b954567aea88275495d0288
Autor:
Bhagyashree S. Joshi, Sameh A. Youssef, Reinier Bron, Alain de Bruin, Harm H. Kampinga, Inge S. Zuhorn
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103282- (2021)
Summary: Huntington disease (HD) is a devastating neurodegenerative disorder characterized by aggregation of huntingtin (HTT) protein containing expanded polyglutamine (polyQ) tracts. DNAJB6, a member of the DNAJ chaperone family, was reported to eff
Externí odkaz:
https://doaj.org/article/7e72da794b2c4764b06ad74b280ea482
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2485 (2022)
Cell-derived extracellular vesicles (EVs) are effectors of cell-to-cell communication that are in the spotlight as promising candidates for in vivo drug delivery because of their ability to enter cells and deliver cargo. For example, proteins of inte
Externí odkaz:
https://doaj.org/article/fc20a9876cde450ab33b27dbfb3f3f96
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8418 (2022)
Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease with unknown etiology that can be characterized by the presence of demyelinated lesions. Prevailing treatment protocols in MS rely on the modulation of the inflammatory proc
Externí odkaz:
https://doaj.org/article/a2a2ab8105284e4f9a53f81c68ff8c7a
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Nanoparticles are promising tools for nanomedicine in a wide array of therapeutic and diagnostic applications. Yet, despite the advances in the biomedical applications of nanomaterials, relatively few nanomedicines made it to the clinics. The formati
Externí odkaz:
https://doaj.org/article/a8fc4f090a574da08056b28bffc00752
Autor:
Juan Villar-Vesga, Julián Henao-Restrepo, Daniëlle C. Voshart, David Aguillon, Andrés Villegas, Diana Castaño, Julián D. Arias-Londoño, Inge S. Zuhorn, Laís Ribovski, Lara Barazzuol, Gloria P. Cardona-Gómez, Rafael Posada-Duque
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Evidence suggests that extracellular vesicles (EVs) act as mediators and biomarkers of neurodegenerative diseases. Two distinct forms of Alzheimer disease (AD) are known: a late-onset sporadic form (SAD) and an early-onset familial form (FAD). Recent
Externí odkaz:
https://doaj.org/article/b8a7c53b691342daba3e611386f296c6
Autor:
Huaiying Zhang, Damla Keskin, Willy H. de Haan-Visser, Guangyue Zu, Patrick van Rijn, Inge S. Zuhorn
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1964 (2021)
Gene therapy is a promising treatment for hereditary diseases, as well as acquired genetic diseases, including cancer. Facing the complicated physiological and pathological environment in vivo, developing efficient non-viral gene vectors is needed fo
Externí odkaz:
https://doaj.org/article/d7ab6458ceae48b59d21b301d3a768ab
Autor:
Natalia Ortí-Casañ, Yingying Wu, Petrus J. W. Naudé, Peter P. De Deyn, Inge S. Zuhorn, Ulrich L. M. Eisel
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Accumulating experimental evidence shows the important linkage between tumor necrosis factor-α (TNF) and AD, but the exact role of TNF in A
Externí odkaz:
https://doaj.org/article/b25979966f3a451cbf0782759e37c72d
Publikováno v:
Pharmaceutics, Vol 6, Iss 4, Pp 557-583 (2014)
The blood–brain barrier acts as a physical barrier that prevents free entry of blood-derived substances, including those intended for therapeutic applications. The development of molecular Trojan horses is a promising drug targeting technology that
Externí odkaz:
https://doaj.org/article/579c748e1d424aa99b8095a133a63ff4
Autor:
Katica Stojanov, Erik F.J. de Vries, Dick Hoekstra, Aren van Waarde, Rudi A.J.O. Dierckx, Inge S. Zuhorn
Publikováno v:
Molecular Imaging, Vol 11 (2012)
The introduction of neural stem cells into the brain has promising therapeutic potential for the treatment of neurodegenerative diseases. To monitor the cellular replacement therapy, that is, to determine stem cell migration, survival, and differenti
Externí odkaz:
https://doaj.org/article/a11b677c5dff4752ab19095441aeb110