Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Inge R. Holtman"'
Autor:
Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna P. Ainslie, Luiza Reali Nazario, Fleur van Buuren-Broek, Ayla C. Scholma, Hilmar R.J. van Weering, Nieske Brouwer, Jeffrey Sewdihal, Uilke Brouwer, Rob P. Coppes, Inge R. Holtman, Bart J.L. Eggen, Susanne M. Kooistra, Lara Barazzuol
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113764- (2024)
Summary: Over half of patients with brain tumors experience debilitating and often progressive cognitive decline after radiotherapy treatment. Microglia, the resident macrophages in the brain, have been implicated in this decline. In response to vari
Externí odkaz:
https://doaj.org/article/bae07cfdb73044fea7306f15d1eb7d28
Autor:
Maren Stolp Andersen, Manuela Tan, Inge R. Holtman, John Hardy, International Parkinson's Disease Genomics Consortium, Lasse Pihlstrøm
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 8, Pp 1289-1295 (2022)
Abstract Parkinson's disease and Alzheimer's disease show overlapping features both clinically and neuropathologically and elucidating shared mechanisms could have important implications for therapeutic strategies. Evidence for genetic overlap is lim
Externí odkaz:
https://doaj.org/article/0db31bf225c94953a92f8af0974f82d4
Autor:
Alexi Nott, Inge R. Holtman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Microglia, the macrophages of the brain, are vital for brain homeostasis and have been implicated in a broad range of brain disorders. Neuroinflammation has gained traction as a possible therapeutic target for neurodegeneration, however, the precise
Externí odkaz:
https://doaj.org/article/aedfb94a0f2c4cf3929513c06cdd49dc
Autor:
Divya Raj, Zhuoran Yin, Marjolein Breur, Janine Doorduin, Inge R. Holtman, Marta Olah, Ietje J. Mantingh-Otter, Debby Van Dam, Peter P. De Deyn, Wilfred den Dunnen, Bart J. L. Eggen, Sandra Amor, Erik Boddeke
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Chronic neuroinflammation, which is primarily mediated by microglia, plays an essential role in aging and neurodegeneration. It is still unclear whether this microglia-induced neuroinflammation occurs globally or is confined to distinct brain regions
Externí odkaz:
https://doaj.org/article/9439d85e5db044c7933800e88c63d130
Autor:
Alyse de Boer, Aletta M.R. van den Bosch, Nienke J. Mekkes, Nina Fransen, Eric Hoekstra, Joost Smolders, Jörg Hamann, Inge Huitinga, Inge R. Holtman
Multiple sclerosis (MS) is a heterogeneous disorder with regards to clinical presentation and pathophysiology. Stratification into biologically distinct subgroups could enhance prognostication and efficacious allocation to disease-modifying therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c044576007e1b87da8ece0b5a9761da7
https://doi.org/10.1101/2023.05.15.23289980
https://doi.org/10.1101/2023.05.15.23289980
Autor:
Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna P. Ainslie, Luiza Reali Nazario, Fleur van Buuren-Broek, Ayla C. Scholma, Nieske Brouwer, Jeffrey Sewdihal, Uilke Brouwer, Rob P. Coppes, Inge R. Holtman, Bart J.L. Eggen, Susanne M. Kooistra, Lara Barazzuol
SummaryMore than half of all brain tumour survivors experience debilitating and often progressive cognitive decline after treatment with radiotherapy. Microglia, the resident macrophages in the brain, have been implicated in this decline. In response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f71502130d4c0f871db0431181da7158
https://doi.org/10.1101/2023.05.10.539581
https://doi.org/10.1101/2023.05.10.539581
Autor:
Maren Stolp Andersen, Lynne Krohn, Ziv Gan-Or, Lasse Pihlstrøm, Inge R. Holtman, Sara Bandres-Ciga, Regina H. Reynolds, Mina Ryten, John Hardy
Publikováno v:
Annals of Neurology, 89(5), 942-951. Wiley
Objective Understanding how different parts of the immune system contribute to pathogenesis in Parkinson's disease is a burning challenge with important therapeutic implications. We studied enrichment of common variant heritability for Parkinson's di
Autor:
Agnieszka Wlodarczyk, Mads Thomassen, Bart J. L. Eggen, Morten Blaabjerg, Kirstine Nolling Jensen, Morten Meyer, Trevor Owens, Joanna Marczynska, Reza Khorooshi, Inge R. Holtman, Mark Burton, Nasrin Asgari
Publikováno v:
Glia, 69(4), 943-953. Wiley
Wlodarczyk, A, Khorooshi, R M H, Marczynska, J, Holtman, I R, Burton, M, Jensen, K N, Blaabjerg, M, Meyer, M, Thomassen, M, Eggen, B J L, Asgari, N & Owens, T 2021, ' Type I interferon-activated microglia are critical for neuromyelitis optica pathology ', Glia, vol. 69, no. 4, pp. 943-953 . https://doi.org/10.1002/glia.23938
Wlodarczyk, A, Khorooshi, R M H, Marczynska, J, Holtman, I R, Burton, M, Jensen, K N, Blaabjerg, M, Meyer, M, Thomassen, M, Eggen, B J L, Asgari, N & Owens, T 2021, ' Type I interferon-activated microglia are critical for neuromyelitis optica pathology ', Glia, vol. 69, no. 4, pp. 943-953 . https://doi.org/10.1002/glia.23938
Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system (CNS) most frequently mediated by serum autoantibodies against the water channel aquaporin 4, expressed on CNS astrocytes, resulting in primary astrocytopathy. There
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b21ec4df9a60fb6e346101a8646c71e
https://research.rug.nl/en/publications/32701755-bdab-4e88-9bf1-745a1135d88d
https://research.rug.nl/en/publications/32701755-bdab-4e88-9bf1-745a1135d88d
Autor:
Miao Yu, Johannes C. M. Schlachetzki, Christopher K. Glass, James B. Brewer, Fred H. Gage, Inge R. Holtman, Robert A. Rissman, Bing Ren, Nicole G. Coufal, Alexi Nott
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Regina H. Reynolds, John Hardy, Mina Ryten, Lynne Krohn, Inge R. Holtman, Sara Bandres-Ciga, Maren Stolp Andersen, Lasse Pihlstrøm, Ziv Gan-Or
ObjectiveUnderstanding how different parts of the immune system contribute to pathogenesis in Parkinson’s disease is a burning challenge with important therapeutic implications. We studied enrichment of common variant heritability for Parkinson’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88cc03f44da1044db883c00b1606951d
https://doi.org/10.1101/2020.11.25.20238162
https://doi.org/10.1101/2020.11.25.20238162