Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura

Autor: Elien Roose, Claudia Tersteeg, Ruth Demeersseman, An-Sofie Schelpe, Louis Deforche, Inge Pareyn, Aline Vandenbulcke, Nele Vandeputte, Daan Dierickx, Jan Voorberg, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke

Publikováno v: TH Open, Vol 02, Iss 01, Pp e8-e15 (2018)

Abstract In this study, we investigated a case of pregnancy-onset thrombotic thrombocytopenic purpura (TTP). The patient had severely decreased ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13) activity levels d

Externí odkaz: https://doaj.org/article/1e8e322e788b4091aebd010e59ffcefd

Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.

Autor: Louis Deforche, Claudia Tersteeg, Elien Roose, Aline Vandenbulcke, Nele Vandeputte, Inge Pareyn, Elien De Cock, Hanspeter Rottensteiner, Hans Deckmyn, Simon F De Meyer, Karen Vanhoorelbeke

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160388 (2016)

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy linked to a deficiency in the metalloprotease ADAMTS13. In the current study, a novel mouse model for acquired TTP was generated to facilitate development and

Externí odkaz: https://doaj.org/article/f1966b3c66014898b88b297e085fb9e8

Generation of anti-idiotypic antibodies to detect anti-spacer antibody idiotopes in acute thrombotic thrombocytopenic purpura patients

Autor: Inge Pareyn, Rob Fijnheer, Jan Voorberg, Karen Vanhoorelbeke, Simon F. De Meyer, Marina Biganzoli, Bérangère S. Joly, Flora Peyvandi, Hans Deckmyn, An Sofie Schelpe, Elien Roose, Agnès Veyradier, Ilaria Mancini, Paul Coppo

Publikováno v: Haematologica
Haematologica, 104(6), 1268-1276. Ferrata Storti Foundation

In autoantibody-mediated autoimmune diseases, autoantibody profiling allows patients to be stratified and links autoantibodies with disease severity and outcome. However, in immune-mediated thrombotic thrombocytopenic purpura (iTTP) patients, stratif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7e43bc2ccbb40bba421ecb097a1bed
https://doi.org/10.3324/haematol.2018.205666

Inhibition of adamts13: a novel therapy to treat mechanical circulatory support-induced acquired von willebrand syndrome

Autor: Elien Roose, Shannen J. Deconinck, Sophie Susen, E Bennek-Schopping, Christoph Nix, Inge Pareyn, Claudia Tersteeg, An-Sofie Schelpe, Karen Vanhoorelbeke, Aline Vandenbulcke, Antoine Rauch, Steven Jacobs, S. F. De Meyer, Hendrik B. Feys, Bart Meyns

Publikováno v: European Heart Journal. 41

Introduction Bleeding is the most frequent adverse event in patients with continuous flow mechanical circulatory support (CF-MCS) and has been linked to the occurrence of acquired von Willebrand syndrome (aVWS). MCS devices cause an increased shear-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4fbec6dbce711b31d905085e794f612
https://doi.org/10.1093/ehjci/ehaa946.3836

Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura

Autor: Ygal Benhamou, Andreas Greinacher, Rob Fijnheer, Gilles Kaplanski, Aline Vandenbulcke, Agnès Veyradier, An Sofie Schelpe, György Sinkovits, Bernhard Lämmle, Charlotte Dekimpe, Marienn Réti, Jan Voorberg, Tanja Falter, Elien Roose, Karen Vanhoorelbeke, Flora Peyvandi, Charis von Auer, Ilaria Mancini, Maelle Le Besnerais, Hans Deckmyn, Inge Pareyn, Heidi Rossmann, Edwige Tellier, Hendrik B. Feys, Bérangère S. Joly, Paul Coppo, Zoltán Prohászka, Simon F. De Meyer

Publikováno v: Blood
Blood, 2020, ⟨10.1182/blood.2019004221⟩
Blood, American Society of Hematology, 2020, ⟨10.1182/blood.2019004221⟩
Blood, 136(3), 353-361. American Society of Hematology

Recently, we showed that ADAMTS13 circulates in an open conformation during the acute phase of immune-mediated thrombotic thrombocytopenic purpura (iTTP). Although the cause of this conformational change remains elusive, ADAMTS13 is primarily closed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20044f896d388337cc7297ef42b1b6fa
https://hal.inrae.fr/hal-03157544