Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Inge Mannaerts"'
Autor:
Vincent De Smet, Elif Gürbüz, Nathalie Eysackers, Liza Dewyse, Ayla Smout, Mina Kazemzadeh Dastjerd, Pierre Lefesvre, Nouredin Messaoudi, Hendrik Reynaert, Stefaan Verhulst, Inge Mannaerts, Leo A. van Grunsven
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101036- (2024)
Background & Aims: Chronic liver disease (CLD) remains a global health issue associated with a significant disease burden. Liver fibrosis, a hallmark of CLD, is characterised by the activation of hepatic stellate cells (HSCs) that gain profibrotic ch
Externí odkaz:
https://doaj.org/article/a220db56f1c24cd99ae3f6a1a5825e81
Autor:
Xiaojie Yu, Natalia Elfimova, Marion Müller, Daniel Bachurski, Ulrike Koitzsch, Uta Drebber, Esther Mahabir, Hinrich P. Hansen, Scott L. Friedman, Sabine Klein, Hans Peter Dienes, Marianna Hösel, Reinhard Buettner, Jonel Trebicka, Vangelis Kondylis, Inge Mannaerts, Margarete Odenthal
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1701-1716 (2022)
Background & Aims: Liver fibrosis arises from long-term chronic liver injury, accompanied by an accelerated wound healing response with interstitial accumulation of extracellular matrix (ECM). Activated hepatic stellate cells (HSC) are the main sourc
Externí odkaz:
https://doaj.org/article/4c80ebac8aa7408c99ac2c230a18d43f
Autor:
Vincent De Smet, Nathalie Eysackers, Vincent Merens, Mina Kazemzadeh Dastjerd, Georg Halder, Stefaan Verhulst, Inge Mannaerts, Leo A. van Grunsven
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021)
Abstract Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently, HSC-based therapeutic candidates largely focus o
Externí odkaz:
https://doaj.org/article/8ea65b2a9036464990e291a1c81feff9
Autor:
Stefaan Verhulst, Elise Anne van Os, Vincent De Smet, Nathalie Eysackers, Inge Mannaerts, Leo A. van Grunsven
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Liver sinusoidal endothelial cells have a gatekeeper function in liver homeostasis by permitting substrates from the bloodstream into the space of Disse and regulating hepatic stellate cell activation status. Maintenance of LSEC's highly specialized
Externí odkaz:
https://doaj.org/article/f46cb7bc70ac436c9cf53041418e0672
Autor:
Joeri Lambrecht, Stefaan Verhulst, Inge Mannaerts, Jan-Peter Sowa, Jan Best, Ali Canbay, Hendrik Reynaert, Leo A. van Grunsven
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 501-512 (2019)
Background: Platelet Derived Growth Factor Receptor beta (PDGFRβ) has been associated to hepatic stellate cell activation and has been the target of multiple therapeutic studies. However, little is known concerning its use as a diagnostic agent. Met
Externí odkaz:
https://doaj.org/article/5f85e40af5a64303a768e25e13006a94
Publikováno v:
Cancers, Vol 13, Iss 23, p 5914 (2021)
Primary and secondary liver cancer are the third cause of death in the world, and as the incidence is increasing, liver cancer represents a global health burden. Current treatment strategies are insufficient to permanently cure patients from this dev
Externí odkaz:
https://doaj.org/article/686a35c1083e420d8ccc2916dc55145c
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
P311 was first identified by the group of Studler et al. (1993) in the developing brain. In healthy, but mainly in pathological tissues, P311 is implicated in cell migration and proliferation. Furthermore, evidence in models of tissue fibrosis points
Externí odkaz:
https://doaj.org/article/4b2966d8481f4802805d22a6616f78c0
Autor:
Inge Mannaerts, Nathalie Eysackers, Oscar O Onyema, Katrien Van Beneden, Sergio Valente, Antonello Mai, Margarete Odenthal, Leo A van Grunsven
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55786 (2013)
BackgroundThe conversion of a quiescent vitamin A storing hepatic stellate cell (HSC) to a matrix producing, contractile myofibroblast-like activated HSC is a key event in the onset of liver disease following injury of any aetiology. Previous studies
Externí odkaz:
https://doaj.org/article/6144dd832fc24bf0a35956ebb8b9d756
Autor:
Inge Mannaerts, Ben Schroyen, Stefaan Verhulst, Leentje Van Lommel, Frans Schuit, Marc Nyssen, Leo A van Grunsven
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84071 (2013)
BACKGROUND: Scarring of the liver is the result of prolonged exposure to exogenous or endogenous stimuli. At the onset of fibrosis, quiescent hepatic stellate cells (HSCs) activate and transdifferentiate into matrix producing, myofibroblast-like cell
Externí odkaz:
https://doaj.org/article/93b1bde42e3148d6936b0d3dd3616c96
Publikováno v:
Methods in Molecular Biology ISBN: 9781071632062
In vitro models of liver fibrosis have evolved from mono-cultures of primary rodent hepatic stellate cells and stellate cell lines, to more complex co-cultures of primary or stem cell-derived liver cells. Great progress has been made in the developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8044085d53c37b440c52c1559393cece
https://biblio.vub.ac.be/vubir/generation-and-culture-of-primary-mouse-hepatocytehepatic-stellate-cell-spheroids(ef299663-68a1-4ed6-aad3-9f38734d2e58).html
https://biblio.vub.ac.be/vubir/generation-and-culture-of-primary-mouse-hepatocytehepatic-stellate-cell-spheroids(ef299663-68a1-4ed6-aad3-9f38734d2e58).html