Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Inge Grundke-Iqbal"'
Autor:
Syed Faraz Kazim, Maria Del Carmen Cardenas-Aguayo, Mohammad Arif, Julie Blanchard, Fatima Fayyaz, Inge Grundke-Iqbal, Khalid Iqbal
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118627 (2015)
Autism is a neurodevelopmental disorder characterized clinically by impairments in social interaction and verbal and non-verbal communication skills as well as restricted interests and repetitive behavior. It has been hypothesized that altered brain
Externí odkaz:
https://doaj.org/article/498060d6645d4890987fdabf79a3f9ae
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145441 (2015)
Deficiency of protein phosphatase-2A is a key event in Alzheimer's disease. An endogenous inhibitor of protein phosphatase-2A, inhibitor-1, I1PP2A, which inhibits the phosphatase activity by interacting with its catalytic subunit protein phosphatase-
Externí odkaz:
https://doaj.org/article/16e459f789194261946582f29e0700a7
Autor:
Xin-Wen Zhou, Xu Li, Cecilia Bjorkdahl, Magnus J. Sjogren, Irina Alafuzoff, Hilkka Soininen, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad, Jin-Jing Pei
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 3, Pp 657-668 (2006)
Alzheimer's disease (AD) is characterized neuropathologically by neuritic plaques (NPs), and neurofibrillary tangles (NFTs). So far, the following key issues are not yet answered to the disease: (1) the accumulation degrees of three Aβ variants, and
Externí odkaz:
https://doaj.org/article/95692e865e09476d8b67ab63c9ea5109
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53596 (2013)
The level of brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is down regulated in Alzheimer's disease (AD), Parkinson's disease (PD), depression, stress, and anxiety; conversely the level of this neurotrophin is increas
Externí odkaz:
https://doaj.org/article/484e658998654683a4c6cf2f073fe5af
Autor:
Yanxing Chen, Zhu Tian, Zhihou Liang, Shenggang Sun, Chun-Ling Dai, Moon H Lee, Frank M LaFerla, Inge Grundke-Iqbal, Khalid Iqbal, Fei Liu, Cheng-Xin Gong
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51432 (2012)
Alzheimer's disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD). Most AD cases are sporadic and may result from multiple etiologic factors, including environmental, genetic and metabolic factors, whereas FAD is caused by mutation
Externí odkaz:
https://doaj.org/article/b925367975d240459302aebf8b4a08f8
Autor:
Ying Liu, Xiaojing Li, Yang Yu, Jianhua Shi, Zhihou Liang, Xiaoqin Run, Yi Li, Chun-ling Dai, Inge Grundke-Iqbal, Khalid Iqbal, Fei Liu, Cheng-Xin Gong
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43724 (2012)
O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins by β-N-acetylglucosamine (GlcNAc). The dynamic addition and removal of O-GlcNAc groups to and from proteins are catalyzed by O-linked N-acetylglucosamine transf
Externí odkaz:
https://doaj.org/article/5d92d290dacf402aa99ac4bdf76c10f4
Autor:
Yang Yu, Lan Zhang, Xiaojing Li, Xiaoqin Run, Zhihou Liang, Yi Li, Ying Liu, Moon H Lee, Inge Grundke-Iqbal, Khalid Iqbal, David J Vocadlo, Fei Liu, Cheng-Xin Gong
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35277 (2012)
Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD). The aggregation of hyperphosphorylated tau into neurofibrillary tangles is also a hallmark brain lesion of AD.
Externí odkaz:
https://doaj.org/article/80f37ffca10b4571acc9a2b1c9580bfe
Biochemical Markers for Alzheimer Disease as Reflection of the Neuropathology in Cerebrospinal Fluid
Publikováno v:
Alzheimer Disease ISBN: 9781003067665
Alzheimer Disease
Alzheimer Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969e409388e434992ebcb880af796426
https://doi.org/10.1201/9781003067665-18
https://doi.org/10.1201/9781003067665-18
Publikováno v:
Journal of Alzheimer's Disease. 45:423-435
Protein phosphatase-2A (PP2A) deficiency is a cause of the abnormal hyperphosphorylation of tau, which composes neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brain. We previously reported that both mRNA and protein expression of inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c05aadf58b8661c468fa713ec2a7f1
https://doi.org/10.3233/jad-142403
https://doi.org/10.3233/jad-142403
Autor:
Julie Blanchard, Syed Faraz Kazim, Frank M. LaFerla, Yunn Chyn Tung, Chun-ling Dai, Inge-Grundke Iqbal, Khalid Iqbal
Publikováno v:
Neurobiology of Disease, Vol 71, Iss, Pp 110-130 (2014)
Besides the presence of amyloid beta (Aβ) plaques and neurofibrillary tangles, neurogenesis and synaptic plasticity are markedly impaired in Alzheimer's disease (AD) possibly contributing to cognitive impairment. In this context, neurotrophic factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de12a8a826d06f3249804ca608a7907
http://www.sciencedirect.com/science/article/pii/S0969996114001958
http://www.sciencedirect.com/science/article/pii/S0969996114001958