Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Inge Grundke-Iqba"'
Autor:
Niloufar Haque, Sabiha Khatoon, Hitoshi Tanimukai, Jin-Jing Pei, Cheng-Xin Gong, Ezzat El-Akkad, Jian-Zhi Wang, Inge Grundke-Iqba, Ichiro Tsujio, K. Iqbal, Alejandra del C. Alonso
Publikováno v:
Journal of Molecular Neuroscience. 20:425-430
Neurofibrillary degeneration has primary and pivotal involvement in the pathogenesis of Alzheimer disease (AD) and other tauopathies. The inhibition of this lesion offers a promising therapeutic approach. The microtubule- associated protein (MAP) tau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be85ac27945798da11d5df1cd1809dac
https://doi.org/10.1385/jmn:20:3:425
https://doi.org/10.1385/jmn:20:3:425
Autor:
Syed Faraz Kazim, Maria Del Carmen Cardenas-Aguayo, Mohammad Arif, Julie Blanchard, Fatima Fayyaz, Inge Grundke-Iqbal, Khalid Iqbal
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118627 (2015)
Autism is a neurodevelopmental disorder characterized clinically by impairments in social interaction and verbal and non-verbal communication skills as well as restricted interests and repetitive behavior. It has been hypothesized that altered brain
Externí odkaz:
https://doaj.org/article/498060d6645d4890987fdabf79a3f9ae
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145441 (2015)
Deficiency of protein phosphatase-2A is a key event in Alzheimer's disease. An endogenous inhibitor of protein phosphatase-2A, inhibitor-1, I1PP2A, which inhibits the phosphatase activity by interacting with its catalytic subunit protein phosphatase-
Externí odkaz:
https://doaj.org/article/16e459f789194261946582f29e0700a7
Autor:
Xin-Wen Zhou, Xu Li, Cecilia Bjorkdahl, Magnus J. Sjogren, Irina Alafuzoff, Hilkka Soininen, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad, Jin-Jing Pei
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 3, Pp 657-668 (2006)
Alzheimer's disease (AD) is characterized neuropathologically by neuritic plaques (NPs), and neurofibrillary tangles (NFTs). So far, the following key issues are not yet answered to the disease: (1) the accumulation degrees of three Aβ variants, and
Externí odkaz:
https://doaj.org/article/95692e865e09476d8b67ab63c9ea5109
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53596 (2013)
The level of brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is down regulated in Alzheimer's disease (AD), Parkinson's disease (PD), depression, stress, and anxiety; conversely the level of this neurotrophin is increas
Externí odkaz:
https://doaj.org/article/484e658998654683a4c6cf2f073fe5af
Autor:
Yanxing Chen, Zhu Tian, Zhihou Liang, Shenggang Sun, Chun-Ling Dai, Moon H Lee, Frank M LaFerla, Inge Grundke-Iqbal, Khalid Iqbal, Fei Liu, Cheng-Xin Gong
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51432 (2012)
Alzheimer's disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD). Most AD cases are sporadic and may result from multiple etiologic factors, including environmental, genetic and metabolic factors, whereas FAD is caused by mutation
Externí odkaz:
https://doaj.org/article/b925367975d240459302aebf8b4a08f8
Autor:
Ying Liu, Xiaojing Li, Yang Yu, Jianhua Shi, Zhihou Liang, Xiaoqin Run, Yi Li, Chun-ling Dai, Inge Grundke-Iqbal, Khalid Iqbal, Fei Liu, Cheng-Xin Gong
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43724 (2012)
O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins by β-N-acetylglucosamine (GlcNAc). The dynamic addition and removal of O-GlcNAc groups to and from proteins are catalyzed by O-linked N-acetylglucosamine transf
Externí odkaz:
https://doaj.org/article/5d92d290dacf402aa99ac4bdf76c10f4
Autor:
Yang Yu, Lan Zhang, Xiaojing Li, Xiaoqin Run, Zhihou Liang, Yi Li, Ying Liu, Moon H Lee, Inge Grundke-Iqbal, Khalid Iqbal, David J Vocadlo, Fei Liu, Cheng-Xin Gong
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35277 (2012)
Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD). The aggregation of hyperphosphorylated tau into neurofibrillary tangles is also a hallmark brain lesion of AD.
Externí odkaz:
https://doaj.org/article/80f37ffca10b4571acc9a2b1c9580bfe