Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Inge E. A. Flesch"'
Autor:
Nathan P Croft, Stewart A Smith, Yik Chun Wong, Chor Teck Tan, Nadine L Dudek, Inge E A Flesch, Leon C W Lin, David C Tscharke, Anthony W Purcell
Publikováno v:
PLoS Pathogens, Vol 9, Iss 1, p e1003129 (2013)
Current knowledge about the dynamics of antigen presentation to T cells during viral infection is very poor despite being of fundamental importance to our understanding of anti-viral immunity. Here we use an advanced mass spectrometry method to simul
Externí odkaz:
https://doaj.org/article/6a1915d21ff04a768d317385c5da648c
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003329 (2013)
Immunodominance is a fundamental property of CD8(+) T cell responses to viruses and vaccines. It had been observed that route of administration alters immunodominance after vaccinia virus (VACV) infection, but only a few epitopes were examined and no
Externí odkaz:
https://doaj.org/article/145f7e8c47cc481c895b4a4e2674a510
Publikováno v:
Journal of Virology. 94
Robust priming of CD8+ T cells by viruses is considered to require infection and de novo expression of viral antigens. A corollary of this is that inactivated viruses are thought of as being inevitably poor vaccines for eliciting these responses. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a327808cb6fb6a7edeab2769d709de14
https://doi.org/10.1128/jvi.01486-20
https://doi.org/10.1128/jvi.01486-20
Publikováno v:
Journal of Virology
The design of viral vectored vaccines is often considered to require a trade-off between efficacy and safety. This is especially the case for vaccines that aim to induce killer (CD8+) T cells, where there is a well-established dogma that links infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fa29f480926225b01a2e7d3c0b0c31a
https://pubmed.ncbi.nlm.nih.gov/32759313
https://pubmed.ncbi.nlm.nih.gov/32759313
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39533 (2012)
Enumeration of anti-viral CD8(+) T cells to make comparisons between mice, viruses and vaccines is a frequently used approach, but controversy persists as to the most appropriate methods. Use of peptide-MHC tetramers (or variants) and intracellular s
Externí odkaz:
https://doaj.org/article/de3b264b880542d68f1d0341f77133a6
Autor:
Sally L Heading, Bjoern Peters, Inge E. A. Flesch, A. J. Stewart Smith, Anthony W. Purcell, Prince Sebastian, Jana Pickering, David C. Tscharke, Matthew J Witney, Nathan P. Croft, Alessandro Sette, Pouya Faridi, John Sidney, Nicole L. La Gruta
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance CD8+ T cells are key to the defense of animals against virus infection. These immune cells recognize peptides derived from viral proteins that are displayed on the surface of infected cells in a complex with host proteins known as MHC I.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e599974cff6da8bfe381358bd8bc8b4
https://pubmed.ncbi.nlm.nih.gov/30718433
https://pubmed.ncbi.nlm.nih.gov/30718433
Autor:
Natasha A. Hollett, David C. Tscharke, Debbie R. Howard, Bárbara Resende Quinan, Inge E. A. Flesch, Flávio Guimarães da Fonseca, Yik Chun Wong
Publikováno v:
The Journal of Immunology. 195:2263-2272
CD8+ T cells that recognize virus-derived peptides presented on MHC class I are vital antiviral effectors. Such peptides presented by any given virus vary greatly in immunogenicity, allowing them to be ranked in an immunodominance hierarchy. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::798e4b42004f68484089c4a847ce88d3
https://doi.org/10.4049/jimmunol.1402508
https://doi.org/10.4049/jimmunol.1402508
Autor:
Christopher C. Goodnow, Inge E. A. Flesch, Hsei Di Law, Natasha A. Hollett, David C. Tscharke, Katrina L. Randall, Lisa A. Miosge, Yovina Sontani
Publikováno v:
Immunology and cell biology
DOCK8 deficiency in humans and mice leads to multiple defects in immune cell numbers and function. Patients with this immunodeficiency have a high morbidity and mortality, and are distinguished by chronic cutaneous viral infections, including those c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc88feba49634575baca62e2dba50ac5
http://europepmc.org/articles/PMC4496291
http://europepmc.org/articles/PMC4496291
Autor:
Fabiana Magalhães Coelho, Flávio Guimarães da Fonseca, Inge E. A. Flesch, Bárbara Resende Quinan, Tânia M.G. Pinho, David C. Tscharke
Publikováno v:
Vaccine. 32(25):2972-2979
Dengue is a global public health concern and this is aggravated by a lack of vaccines or antiviral therapies. Despite the well-known role of CD8(+) T cells in the immunopathogenesis of Dengue virus (DENV), only recent studies have highlighted the imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46d9ea55190766007fcd06fbb841dc9
Publikováno v:
Journal of Virology. 83:9008-9012
Heterologous prime-boost is a common vaccination strategy to elicit CD8 + T cells (T CD8+ ), and vaccinia virus (VACV) has been widely used as a boosting vector. Studies with other viruses have suggested that priming may reduce responses to native ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d2c2cc089c67de55358b3e8eaa7d9a
https://doi.org/10.1128/jvi.00410-09
https://doi.org/10.1128/jvi.00410-09