Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Inge E A Flesch"'
Autor:
Nathan P Croft, Stewart A Smith, Yik Chun Wong, Chor Teck Tan, Nadine L Dudek, Inge E A Flesch, Leon C W Lin, David C Tscharke, Anthony W Purcell
Publikováno v:
PLoS Pathogens, Vol 9, Iss 1, p e1003129 (2013)
Current knowledge about the dynamics of antigen presentation to T cells during viral infection is very poor despite being of fundamental importance to our understanding of anti-viral immunity. Here we use an advanced mass spectrometry method to simul
Externí odkaz:
https://doaj.org/article/6a1915d21ff04a768d317385c5da648c
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003329 (2013)
Immunodominance is a fundamental property of CD8(+) T cell responses to viruses and vaccines. It had been observed that route of administration alters immunodominance after vaccinia virus (VACV) infection, but only a few epitopes were examined and no
Externí odkaz:
https://doaj.org/article/145f7e8c47cc481c895b4a4e2674a510
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39533 (2012)
Enumeration of anti-viral CD8(+) T cells to make comparisons between mice, viruses and vaccines is a frequently used approach, but controversy persists as to the most appropriate methods. Use of peptide-MHC tetramers (or variants) and intracellular s
Externí odkaz:
https://doaj.org/article/de3b264b880542d68f1d0341f77133a6
Publikováno v:
Journal of Virology. 94
Robust priming of CD8+ T cells by viruses is considered to require infection and de novo expression of viral antigens. A corollary of this is that inactivated viruses are thought of as being inevitably poor vaccines for eliciting these responses. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a327808cb6fb6a7edeab2769d709de14
https://doi.org/10.1128/jvi.01486-20
https://doi.org/10.1128/jvi.01486-20
Publikováno v:
Journal of Virology
The design of viral vectored vaccines is often considered to require a trade-off between efficacy and safety. This is especially the case for vaccines that aim to induce killer (CD8+) T cells, where there is a well-established dogma that links infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fa29f480926225b01a2e7d3c0b0c31a
https://pubmed.ncbi.nlm.nih.gov/32759313
https://pubmed.ncbi.nlm.nih.gov/32759313
Autor:
Natasha A. Hollett, David C. Tscharke, Debbie R. Howard, Bárbara Resende Quinan, Inge E. A. Flesch, Flávio Guimarães da Fonseca, Yik Chun Wong
Publikováno v:
The Journal of Immunology. 195:2263-2272
CD8+ T cells that recognize virus-derived peptides presented on MHC class I are vital antiviral effectors. Such peptides presented by any given virus vary greatly in immunogenicity, allowing them to be ranked in an immunodominance hierarchy. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::798e4b42004f68484089c4a847ce88d3
https://doi.org/10.4049/jimmunol.1402508
https://doi.org/10.4049/jimmunol.1402508
Autor:
Christopher C. Goodnow, Inge E. A. Flesch, Hsei Di Law, Natasha A. Hollett, David C. Tscharke, Katrina L. Randall, Lisa A. Miosge, Yovina Sontani
Publikováno v:
Immunology and cell biology
DOCK8 deficiency in humans and mice leads to multiple defects in immune cell numbers and function. Patients with this immunodeficiency have a high morbidity and mortality, and are distinguished by chronic cutaneous viral infections, including those c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc88feba49634575baca62e2dba50ac5
http://europepmc.org/articles/PMC4496291
http://europepmc.org/articles/PMC4496291
Autor:
Fabiana Magalhães Coelho, Flávio Guimarães da Fonseca, Inge E. A. Flesch, Bárbara Resende Quinan, Tânia M.G. Pinho, David C. Tscharke
Publikováno v:
Vaccine. 32(25):2972-2979
Dengue is a global public health concern and this is aggravated by a lack of vaccines or antiviral therapies. Despite the well-known role of CD8(+) T cells in the immunopathogenesis of Dengue virus (DENV), only recent studies have highlighted the imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46d9ea55190766007fcd06fbb841dc9
Autor:
Michael S. Rolph, Inge E. A. Flesch, Stefan H. E. Kaufmann, Brigitte G. Dorner, Richard A. Kroczek, Alexander Scheffold, Martin B. Huser, Andreas Radbruch
Publikováno v:
Proceedings of the National Academy of Sciences. 99:6181-6186
We analyzed for the first time the expression of chemokines in subpopulations of the murine immune system at the single-cell level. We demonstrate in vitro and in a model of murine listeriosis that macrophage inflammatory protein (MIP)-1α, MIP-1β,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa6a810c319d5d745b4d51f749c6584e
https://doi.org/10.1073/pnas.092141999
https://doi.org/10.1073/pnas.092141999
Publikováno v:
International Immunology. 12:1365-1370
Dendritic cells (DC) derived from bone marrow precursors of BALB/c or C57BL/6 mice in low-serum cultures supplemented with granulocyte macrophage colony stimulating factor and Flt(3) ligand were pulsed in vitro with hepatitis B surface antigen (HBsAg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea93289e0940d181c5d556f0f8a0944
https://doi.org/10.1093/intimm/12.9.1365
https://doi.org/10.1093/intimm/12.9.1365