Increased cyclooxygenase-2 expression and prostaglandin E2production in pressurized renal medullary interstitial cells

Autor: Inge Carlsen, Kaitlin E. Donohue, Jørgen Frøkiær, Dix P. Poppas, Angela L. Selzer, Jie Chen, Rikke Nørregaard, Diane Felsen, Anja M. Jensen

Publikováno v: Carlsen, I G, Donohue, K E, Jensen, A M, Selzer, A L, Chen, J, Poppas, D P, Felsen, D, Frøkiær, J & Nørregaard, R 2010, ' Increased cyclooxygenase-2 expression and prostaglandin E2 production in pressurized renal medullary interstitial cells ', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology . https://doi.org/10.1152/ajpregu.00544.2009

Renal medullary interstitial cells (RMICs) are subjected to osmotic, inflammatory, and mechanical stress as a result of ureteral obstruction, which may influence the expression and activity of cyclooxygenase type 2 (COX-2). Inflammatory stress strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68859423534400a1346e0b1c1dca03f2
https://doi.org/10.1152/ajpregu.00544.2009

Proteomic identification of early changes in the renal cytoskeleton in obstructive uropathy

Autor: Jørgen Frøkiær, Line Nilsson, Lene Stødkilde, Inge Carlsen, Yan Wang, Johan Palmfeldt, Rikke Nørregaard

Publikováno v: Stødkilde-Jørgensen, L, Palmfeldt, J, Nilsson, L, Carlsen, I G, Wang, Y, Nørregaard, R & Frøkiær, J 2014, ' Proteomic identification of early changes in the renal cytoskeleton in obstructive uropathy ', A J P: Renal Physiology (Online), vol. 306, no. 12 . https://doi.org/10.1152/ajprenal.00244.2013

Bilateral ureteral obstruction (BUO) is associated with renal damage and impaired ability to concentrate urine and is known to induce alterations in an array of kidney proteins. The aim of this study was to identify acute proteomic alterations induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab6e2c5da7029b1cc27dac5082edf48
https://pure.au.dk/portal/da/publications/proteomic-identification-of-early-changes-in-the-renal-cytoskeleton-in-obstructive-uropathy(77ab6cd3-82b9-4adf-a95f-63eba250d0ff).html

ROS-dependence of cyclooxygenase-2 induction in rats subjected to unilateral ureteral obstruction

Autor: Rikke Nørregaard, Jørgen Frøkiær, Inge Carlsen, Martin Østergaard, Michael Christensen, Line Nilsson

Publikováno v: Oestergaard, M, Christensen, M, Nilsson, L, Carlsen, I, Frokiaer, J & Norregaard, R 2014, ' ROS-dependence of cyclooxygenase-2 induction in rats subjected to unilateral ureteral obstruction ', A J P: Renal Physiology (Online), vol. 306(2), pp. F258-70 . https://doi.org/10.1152/ajprenal.00352.2013

Oxidative stress resulting from unilateral ureteral obstruction (UUO) may be aggravated by increased production of ROS. Previous studies have demonstrated increased cyclooxygenase (COX)-2 expression in renal medullary interstitial cells (RMICs) in re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cace7b5553433d2050133aaefa17068a
https://pure.au.dk/portal/da/publications/rosdependence-of-cyclooxygenase2-induction-in-rats-subjected-to-unilateral-ureteral-obstruction(d9e89cde-4c25-4df6-ab82-66b0a7ffe830).html

HSP27 regulation in acute unilateral obstructed kidney, along with RMIC and collecting duct cells subjected to mechanical, oxidative, and inflammatory stress

Autor: Jørgen Frøkiær, Rikke Nørregaard, Inge Carlsen, Line Nilsson

Publikováno v: The FASEB Journal. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d0f795bc7a370170043710965c52f51
https://doi.org/10.1096/fasebj.26.1_supplement.691.7