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Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma.

Autor: Floros KV; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298 USA., Fairchild CK Jr; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA., Li J; University of Utah, Huntsman Cancer Institute, 2000 Circle of Hope Drive, Salt Lake City, UT 84112 USA., Zhang K; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298 USA., Roberts JL; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298 USA., Kurupi R; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine Saint Louis, MO 63110 USA., Hu B; Department of Pathology, Virginia Commonwealth University and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA., Kraskauskiene V; Department of Pathology, Virginia Commonwealth University and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA., Hosseini N; Department of Pathology, Virginia Commonwealth University and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA., Shen S; Department of Pathology, Virginia Commonwealth University and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA., Inge MM; Department of Biology, Boston University, Boston, MA 02215, USA.; Biological Design Center, Boston University, Boston, MA 02215, USA., Smith-Fry K; University of Utah, Huntsman Cancer Institute, 2000 Circle of Hope Drive, Salt Lake City, UT 84112 USA., Li L; University of Utah, Huntsman Cancer Institute, 2000 Circle of Hope Drive, Salt Lake City, UT 84112 USA., Sotiriou A; Soft Tissue Sarcoma Research Group, Hopp Children's Cancer Center, Heidelberg (KiTZ), German Cancer Research Center (DKFZ), Heidelberg, Germany., Dalton KM; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298 USA., Jose A; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA., Abdelfadiel EI; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298 USA., Xing Y; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298 USA., Hill RD; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298 USA., Slaughter JM; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298 USA., Shende M; Department of Pathology, Virginia Commonwealth University and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA., Lorenz MR; Department of Pathology, Virginia Commonwealth University and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA., Hinojosa MR; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, USA.; Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas, USA., Belvin BR; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA., Lai Z; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, USA.; Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas, USA., Boikos SA; Department of Hematology and Oncology, Georgetown Lombardi Comprehensive Cancer Center, 3800 Reservoir Rd NW Ste E501, Washington, DC 20007 USA., Stamatouli AM; Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia USA., Lewis JP; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA.; Department of Microbiology & Immunology and Massey Cancer Center, Richmond VA, USA., Manjili MH; Department of Microbiology & Immunology and Massey Cancer Center, Richmond VA, USA., Valerie K; Department of Radiation Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond VA, 23298 USA., Li R; Program in Microbiology and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA., Banito A; Soft Tissue Sarcoma Research Group, Hopp Children's Cancer Center, Heidelberg (KiTZ), German Cancer Research Center (DKFZ), Heidelberg, Germany., Poklepovic A; Department of Internal Medicine, Division of Oncology, Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Koblinski JE; Department of Pathology, Virginia Commonwealth University and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA., Siggers T; Department of Biology, Boston University, Boston, MA 02215, USA.; Biological Design Center, Boston University, Boston, MA 02215, USA.; Bioinformatics Program, Boston University, Boston, MA 02215, USA., Dozmorov MG; Department of Biostatistics, Virginia Commonwealth University, Richmond VA, 23298 USA., Jones KB; University of Utah, Huntsman Cancer Institute, 2000 Circle of Hope Drive, Salt Lake City, UT 84112 USA., Radhakrishnan SK; Department of Pathology, Virginia Commonwealth University and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA., Faber AC; VCU Philips Institute, Virginia Commonwealth University School of Dentistry and Massey Comprehensive Cancer Center, Richmond VA, 23298 USA.; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298 USA.

Publikováno v: Research square [Res Sq] 2024 Jun 06. Date of Electronic Publication: 2024 Jun 06.