Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Inge, Huitinga"'
Autor:
Luuk E. de Vries, Aldo Jongejan, Jennifer Monteiro Fortes, Rawien Balesar, Annemieke J. M. Rozemuller, Perry D. Moerland, Inge Huitinga, Dick F. Swaab, Joost Verhaagen
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This phenomenon has been referred to as ‘resilience’. The molecular and cellular underpinnin
Externí odkaz:
https://doaj.org/article/e03528769b2a4a3cb0f3eb56cfdfb93b
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-33 (2024)
Abstract Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer’s Disease (AD) neuropathological changes. This discrepancy between cognition and pathology has been labeled as resilience and has
Externí odkaz:
https://doaj.org/article/366a52247abc420094a7a727d47c1fd6
Autor:
Aletta M. R. van den Bosch, Marlijn van der Poel, Nina L. Fransen, Maria C. J. Vincenten, Anneleen M. Bobeldijk, Aldo Jongejan, Hendrik J. Engelenburg, Perry D. Moerland, Joost Smolders, Inge Huitinga, Jörg Hamann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Microglia nodules (HLA-DR+ cell clusters) are associated with brain pathology. In this post-mortem study, we investigated whether they represent the first stage of multiple sclerosis (MS) lesion formation. We show that microglia nodules are
Externí odkaz:
https://doaj.org/article/598c1f7d0a794ef3b7096efd7cbff052
Autor:
Karel Scheepstra, Mark Mizee, Dennis Wever, Cheng-Chih Hsiao, Lin Zhang, Dick Swaab, Jörg Hamann, Inge Huitinga
Publikováno v:
Neuroscience Insights, Vol 19 (2024)
Inflammation is a prominent hypothesis in the neurobiology of depression. In our transcriptomic profiling study of microglia in chronic major depressive disorder (MDD), we revealed a distinct disease-associated microglia (DAM) transcriptomic profile
Externí odkaz:
https://doaj.org/article/3a24fda6f1c34f68aff8979409289ab2
Autor:
Sabina Luchetti, Philippe Liere, Antoine Pianos, Ronald W.H. Verwer, Arja Sluiter, Inge Huitinga, Michael Schumacher, Dick F. Swaab, Matthew R.J. Mason
Publikováno v:
Neurobiology of Disease, Vol 183, Iss , Pp 106169- (2023)
Neuroactive steroids are known neuroprotective agents and neurotransmitter regulators. We previously found that expression of the enzymes synthesizing 5α-dihydroprogesterone (5α-DHP), allopregnanolone (ALLO), and dehydroepiandrosterone sulfate (DHE
Externí odkaz:
https://doaj.org/article/98b77096537a4453ac25d7b3fb869775
Autor:
Cheng-Chih Hsiao, Hendrik J. Engelenburg, Aldo Jongejan, Jing Zhu, Baohong Zhang, Michael Mingueneau, Perry D. Moerland, Inge Huitinga, Joost Smolders, Jörg Hamann
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105785- (2023)
Summary: The human brain is populated by perivascular T cells with a tissue-resident memory T (TRM)-cell phenotype, which in multiple sclerosis (MS) associate with lesions. We investigated the transcriptional and functional profile of freshly isolate
Externí odkaz:
https://doaj.org/article/ea87777100934dbb94daef45591458fe
Autor:
Vasiliki-Ilya Gargareta, Josefine Reuschenbach, Sophie B Siems, Ting Sun, Lars Piepkorn, Carolina Mangana, Erik Späte, Sandra Goebbels, Inge Huitinga, Wiebke Möbius, Klaus-Armin Nave, Olaf Jahn, Hauke B Werner
Publikováno v:
eLife, Vol 11 (2022)
Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar. Here, we use quantit
Externí odkaz:
https://doaj.org/article/4e5b92e78c254760b002c60c7dec1836
Autor:
Shanzeh M. Ahmed, Nina L. Fransen, Hanane Touil, Iliana Michailidou, Inge Huitinga, Jennifer L. Gommerman, Amit Bar-Or, Valeria Ramaglia
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Subpial cortical demyelination is an important component of multiple sclerosis (MS) pathology contributing to disease progression, yet mechanism(s) underlying its development remain unclear. Compartmentalized inflammation involving the meninges may d
Externí odkaz:
https://doaj.org/article/df6130b85b53448ba53c213de9c6265e
Autor:
Chotima Böttcher, Marlijn van der Poel, Camila Fernández-Zapata, Stephan Schlickeiser, Julia K. H. Leman, Cheng-Chih Hsiao, Mark R. Mizee, Adelia, Maria C. J. Vincenten, Desiree Kunkel, Inge Huitinga, Jörg Hamann, Josef Priller
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-18 (2020)
Abstract Myeloid cells contribute to inflammation and demyelination in the early stages of multiple sclerosis (MS), but it is still unclear to what extent these cells are involved in active lesion formation in progressive MS (PMS). Here, we have harn
Externí odkaz:
https://doaj.org/article/006079524a1148c4a991c13d07a96ce0
Autor:
Jeroen Melief, Marie Orre, Koen Bossers, Corbert G. van Eden, Karianne G. Schuurman, Matthew R. J. Mason, Joost Verhaagen, Jörg Hamann, Inge Huitinga
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract Inter-individual differences in cortisol production by the hypothalamus–pituitary–adrenal (HPA) axis are thought to contribute to clinical and pathological heterogeneity of multiple sclerosis (MS). At the same time, accumulating evidence
Externí odkaz:
https://doaj.org/article/91ae7c2831ea493c9b3564de0c282815