Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Inga Nehlmeier"'
Autor:
Xinyu Ning, Darshita Budhadev, Sara Pollastri, Inga Nehlmeier, Amy Kempf, Iain Manfield, W. Bruce Turnbull, Stefan Pöhlmann, Anna Bernardi, Xin Li, Yuan Guo, Dejian Zhou
Publikováno v:
JACS Au, Vol 4, Iss 8, Pp 3295-3309 (2024)
Externí odkaz:
https://doaj.org/article/757f82838ccf4e62a5f84306bc3cb42c
Autor:
Markus Hoffmann, Lok-Yin Roy Wong, Prerna Arora, Lu Zhang, Cheila Rocha, Abby Odle, Inga Nehlmeier, Amy Kempf, Anja Richter, Nico Joel Halwe, Jacob Schön, Lorenz Ulrich, Donata Hoffmann, Martin Beer, Christian Drosten, Stanley Perlman, Stefan Pöhlmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The SARS-CoV-2 Omicron subvariants BA.1 and BA.2 exhibit reduced lung cell infection relative to previously circulating SARS-CoV-2 variants, which may account for their reduced pathogenicity. However, it is unclear whether lung cell infectio
Externí odkaz:
https://doaj.org/article/d5890df25e6a47a4a0fb537c6e7a81a4
Autor:
Lu Zhang, Alexandra Dopfer-Jablonka, Inga Nehlmeier, Amy Kempf, Luise Graichen, Noemí Calderón Hampel, Anne Cossmann, Metodi V. Stankov, Gema Morillas Ramos, Sebastian R. Schulz, Hans-Martin Jäck, Georg M. N. Behrens, Stefan Pöhlmann, Markus Hoffmann
Publikováno v:
Vaccines, Vol 12, Iss 5, p 487 (2024)
Transmissibility and immune evasion of the recently emerged, highly mutated SARS-CoV-2 BA.2.87.1 are unknown. Here, we report that BA.2.87.1 efficiently enters human cells but is more sensitive to antibody-mediated neutralization than the currently d
Externí odkaz:
https://doaj.org/article/cd69a4083c014053bc288930db5d3c65
Autor:
Markus Hoffmann, Anzhalika Sidarovich, Prerna Arora, Nadine Krüger, Inga Nehlmeier, Amy Kempf, Luise Graichen, Martin S. Winkler, Daniela Niemeyer, Christine Goffinet, Christian Drosten, Sebastian Schulz, Hans-Martin Jäck, Stefan Pöhlmann
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT SARS-CoV-2 variants of concern (VOC) acquired mutations in the spike (S) protein, including E484K, that confer resistance to neutralizing antibodies. However, it is incompletely understood how these mutations impact viral entry into host cel
Externí odkaz:
https://doaj.org/article/b456191be4ea4ac29d1a309a4697f9af
Autor:
Prerna Arora, Amy Kempf, Inga Nehlmeier, Luise Graichen, Martin S. Winkler, Martin Lier, Sebastian Schulz, Hans-Martin Jäck, Anne Cossmann, Metodi V. Stankov, Georg M.N. Behrens, Stefan Pöhlmann, Markus Hoffmann
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110754- (2022)
Summary: Rapid spread of SARS-CoV-2 variants C.1.2 and B.1.621 (Mu variant) in Africa and the Americas, respectively, as well as a high number of mutations in the viral spike proteins raised concerns that these variants might pose an elevated threat
Externí odkaz:
https://doaj.org/article/1fb852d0d9bb437db843675916e4b705
Autor:
Ruth Lydia Olga Lambertz, Ingo Gerhauser, Inga Nehlmeier, Sabine Gärtner, Michael Winkler, Sarah Rebecca Leist, Heike Kollmus, Stefan Pöhlmann, Klaus Schughart
Publikováno v:
Virology Journal, Vol 17, Iss 1, Pp 1-7 (2020)
Abstract The host cell protease TMPRSS2 cleaves the influenza A virus (IAV) hemagglutinin (HA). Several reports have described resistance of Tmprss2 −/− knock-out (KO) mice to IAV infection but IAV of the H2 subtype have not been examined yet. He
Externí odkaz:
https://doaj.org/article/80ba7f63acba4da4966497bb19a13d35
Autor:
Kristin Metzdorf, Henning Jacobsen, Marina C. Greweling-Pils, Markus Hoffmann, Tatjana Lüddecke, Felicitas Miller, Lars Melcher, Amy M. Kempf, Inga Nehlmeier, Dunja Bruder, Marek Widera, Sandra Ciesek, Stefan Pöhlmann, Luka Čičin-Šain
Publikováno v:
Viruses, Vol 15, Iss 2, p 271 (2023)
The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into lung cells, and TMPRSS2 inhibitors are being developed for COVID-19 therap
Externí odkaz:
https://doaj.org/article/4f1096b942ec4b998af992c93448d0a4
Autor:
Prerna Arora, Lu Zhang, Cheila Rocha, Luise Graichen, Inga Nehlmeier, Amy Kempf, Anne Cossmann, Gema Morillas Ramos, Eva Baier, Björn Tampe, Onnen Moerer, Steffen Dickel, Martin S. Winkler, Georg M. N. Behrens, Stefan Pöhlmann, Markus Hoffmann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14057 (2022)
Recently, a recombinant SARS-CoV-2 lineage, XD, emerged that harbors a spike gene that is largely derived from the Omicron variant BA.1 in the genetic background of the Delta variant. This finding raised concerns that the recombinant virus might exhi
Externí odkaz:
https://doaj.org/article/14c4ce1145744cba81384e99b38a7b6f
Autor:
Anzhalika Sidarovich, Nadine Krüger, Cheila Rocha, Luise Graichen, Amy Kempf, Inga Nehlmeier, Martin Lier, Anne Cossmann, Metodi V. Stankov, Sebastian R. Schulz, Georg M. N. Behrens, Hans-Martin Jäck, Stefan Pöhlmann, Markus Hoffmann
Publikováno v:
Viruses, Vol 14, Iss 11, p 2475 (2022)
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitates viral entry into host cells and is the key target for neutralizing antibodies. The SARS-CoV-2 lineage B.1.620 carries fifteen mutations in the S protein
Externí odkaz:
https://doaj.org/article/5777d3dcf3384ed790818719c997e62a
Autor:
Teresa Plegge, Martin Spiegel, Nadine Krüger, Inga Nehlmeier, Michael Winkler, Mariana González Hernández, Stefan Pöhlmann
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214968 (2019)
Emerging viruses such as severe fever and thrombocytopenia syndrome virus (SFTSV) and Ebola virus (EBOV) are responsible for significant morbidity and mortality. Host cell proteases that process the glycoproteins of these viruses are potential target
Externí odkaz:
https://doaj.org/article/94923d9504f14b10b9296b50976b70df