Výsledky vyhledávání

Akademický článek

Molecular architecture of Streptococcus pneumoniae surface thioredoxin‐fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence

Autor: Malek Saleh, Sergio G. Bartual, Mohammed R. Abdullah, Inga Jensch, Tauseef M. Asmat, Lothar Petruschka, Thomas Pribyl, Manuela Gellert, Christopher H. Lillig, Haike Antelmann, Juan A. Hermoso, Sven Hammerschmidt

Publikováno v: EMBO Molecular Medicine, Vol 5, Iss 12, Pp 1852-1870 (2013)

Abstract The respiratory pathogen Streptococcus pneumoniae has evolved efficient mechanisms to resist oxidative stress conditions and to displace other bacteria in the nasopharynx. Here we characterize at physiological, functional and structural leve

Externí odkaz: https://doaj.org/article/2b0324d0639a4157aa467efc73c7a368

Zobrazit plný text záznamu

Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats

Autor: Inga Jensch, Sajida Kanwal, Manfred Rohde, Howard F. Jenkinson, Gottfried J. Palm, Mark Brönstrup, Werner Tegge, Daniela Somplatzki, Sven Hammerschmidt, Thomas P. Kohler

Publikováno v: Molecular Microbiology. 105:839-859

Summary Colonization of mucosal respiratory surfaces is a prerequisite for the human pathobiont Streptococcus pneumoniae (the pneumococcus) to cause severe invasive infections. The arsenal of pneumococcal adhesins interacts with a multitude of extrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60a3304406d8f06e42fbf1a78419f6bd
https://doi.org/10.1111/mmi.13740

Zobrazit plný text záznamu

Fibronectin modulates formation of PF4/heparin complexes and is a potential factor for reducing risk of developing HIT

Autor: Sven Brandt, Patricia Preuße, Elke Hammer, Krystin Krauel, Inga Jensch, Catja Trabhardt, Theodore E. Warkentin, Martin Mandelkow, Andreas Greinacher, Sven Hammerschmidt

Publikováno v: Blood. 133(9)

Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating anti–platelet factor 4 (PF4)/heparin antibodies. Platelet activation assays that use “washed” platelets are more sensitive for detecting HIT antibodies than platelet-rich p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecf9c1c350d74d382a616c8fa802710
https://pubmed.ncbi.nlm.nih.gov/30819779

Zobrazit plný text záznamu

Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats

Autor: Sajida, Kanwal, Inga, Jensch, Gottfried J, Palm, Mark, Brönstrup, Manfred, Rohde, Thomas P, Kohler, Daniela, Somplatzki, Werner, Tegge, Howard F, Jenkinson, Sven, Hammerschmidt

Publikováno v: Molecular microbiology. 105(6)

Colonization of mucosal respiratory surfaces is a prerequisite for the human pathobiont Streptococcus pneumoniae (the pneumococcus) to cause severe invasive infections. The arsenal of pneumococcal adhesins interacts with a multitude of extracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3b43d0ba6418c2a25963c2fb8d259d1
https://pubmed.ncbi.nlm.nih.gov/28657670

Zobrazit plný text záznamu

New insights in heparin-induced thrombocytopenia by the use of fluid-phase assays to detect specifically platelet factor 4/heparin complex antibodies and antibody-secreting cells

Autor: Hans-Peter Müller, Inga Jensch, Adnan Alahmad, Andreas Greinacher, Matthias Hundt, Annika Schulze, Krystin Krauel

Publikováno v: Thrombosis Research. 134:174-181

Introduction The key feature of heparin-induced thrombocytopenia (HIT) is the production of antibodies (Ab) against the platelet factor 4 (PF4)/heparin complex. These Ab are directed against neoepitopes of the PF4 tetramer, which are induced by the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76130650158139857a93176f40667199
https://doi.org/10.1016/j.thromres.2014.04.014

Zobrazit plný text záznamu

Heterologous expression of pneumococcal virulence factor PspC on the surface of Lactococcus lactis confers adhesive properties

Autor: Inga Jensch, Sven Hammerschmidt, Gerhard Burchhardt, Tauseef M. Asmat, Katharina Klingbeil

Publikováno v: Microbiology; Vol 158

Lactococcus lactis is a non-pathogenic bacterium that is used in the food industry but is also used as a heterologous host to reveal protein functions of pathogenic bacteria. The adhesin PspC from Streptococcus pneumoniae is a choline-binding protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01a8c4f169ea24eb948e5f07fc6b6f6
https://doi.org/10.1099/mic.0.053603-0

Zobrazit plný text záznamu

Complement Regulator Factor H Mediates a Two-step Uptake of Streptococcus pneumoniae by Human Cells

Autor: Sven Hammerschmidt, Vaibhav Agarwal, Peter F. Zipfel, Inga Jensch, Tauseef M. Asmat, Shanshan Luo

Publikováno v: Journal of Biological Chemistry. 285:23486-23495

Streptococcus pneumoniae, a human pathogen, recruits complement regulator factor H to its bacterial cell surface. The bacterial PspC protein binds Factor H via short consensus repeats (SCR) 8–11 and SCR19–20. In this study, we define how bacteria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cda9b27cad296d77f44bebb791c1710
https://doi.org/10.1074/jbc.m110.142703

Zobrazit plný text záznamu

PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections

Autor: Marcus Fulde, Daniela Somplatzki, Lothar Petruschka, Inga Jensch, Sandra Ebert, Michael Rothe, Sven Hammerschmidt, Roland Nau, Simone Bergmann, Manfred Rohde, Gustavo Gámez

Publikováno v: Molecular Microbiology. 77:22-43

The genomic analysis of Streptococcus pneumoniae strains identified the Pneumococcal adherence and virulence factor B (PavB), whose repetitive sequences, designated Streptococcal Surface REpeats (SSURE), interact with human fibronectin. Here, we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51ec135a3af6859e9a334d569848faa8
https://doi.org/10.1111/j.1365-2958.2010.07189.x

Zobrazit plný text záznamu

Further insights into the anti-PF4/heparin IgM immune response

Autor: Andreas Greinacher, Tamam Bakchoul, Matthias Hundt, Krystin Krauel, Hansjörg Schwertz, Rabie Jouni, Inga Jensch, Julia van der Linde, Andreas Koster, Annika Schulze, Sixten Selleng, Christine Hackbarth, Bernhard Hietkamp

Publikováno v: Thrombosis and haemostasis. 115(4)

SummaryAnti-platelet factor 4 (PF4)/heparin antibodies are not only the cause of heparin-induced thrombocytopenia but might also play a role in the antibacterial host defence. Recently, marginal zone (MZ) B cells were identified to be crucial for ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeb5e1c7a0631a45e16215b48969bca
https://pubmed.ncbi.nlm.nih.gov/26467272

Zobrazit plný text záznamu

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Autor: Thomas Pribyl, Sven Hammerschmidt, Thomas P. Kohler, Mohammed R. Abdullah, Christian Schulz, Inga Jensch, Malek Saleh

Pneumonia is one of the major health care problems in developing and industrialized countries and is associated with considerable morbidity and mortality. Despite advances in knowledge of this illness, the availability of intensive care units (ICU),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76658912dbb188249329412ff6199af1
https://europepmc.org/articles/PMC4130511/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání