Spatiotemporal assessment of spontaneous metastasis formation using multimodal in vivo imaging in HER2+ and triple negative metastatic breast cancer xenograft models in mice.

Autor: Inga B Fricke, Raquel De Souza, Lais Costa Ayub, Giulio Francia, Robert Kerbel, David A Jaffray, Jinzi Zheng

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0196892 (2018)

Preclinical breast cancer models recapitulating the clinical course of metastatic disease are crucial for drug development. Highly metastatic cell lines forming spontaneous metastasis following orthotopic implantation were previously developed and ch

Externí odkaz: https://doaj.org/article/890f83c3666a49c6a3928d72dc7dcc3d

Suppl. Fig. 1: Experimental design. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Autor: Andreas H. Jacobs, Alexandra Winkeler, Michael Schäfers, Sven Hermann, Michael T. Kuhlmann, Cornelius Faber, Andreas Faust, Stefan Wagner, Katrin Schwegmann, Lisa Honold, Sonja Schelhaas, Inga B. Fricke, Lydia Wachsmuth, Thomas Viel, Benoit Thézé, Hayet Pigeon, Bastian Zinnhardt

Gli36dEGFR cells were implanted. Thereafter, two imaging sequences were conducted: In sequence 1, T2w MRI and PET with [18F]DPA-714 was performed, while [18F]BR-351 PET and [18F]FET PET were conducted at day 13 and 14, respectively. In imaging sequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0216f18421d6c4898467c85050d36071
https://doi.org/10.1158/0008-5472.22417415

Suppl. Fig. 4: Influence of imaging sequence. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Autor: Andreas H. Jacobs, Alexandra Winkeler, Michael Schäfers, Sven Hermann, Michael T. Kuhlmann, Cornelius Faber, Andreas Faust, Stefan Wagner, Katrin Schwegmann, Lisa Honold, Sonja Schelhaas, Inga B. Fricke, Lydia Wachsmuth, Thomas Viel, Benoit Thézé, Hayet Pigeon, Bastian Zinnhardt

(A) T/B ratios, (B-D) tracer volumes, (E-J) areas of unique tracer uptake and overlapping regions. No significant effect on volumetric data was observed based on the order of imaging experiments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a843dfe71ebb02507a4270e4ee203449
https://doi.org/10.1158/0008-5472.22417406.v1

Suppl. Fig. 3: Illustration of the applied thresholding. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Autor: Andreas H. Jacobs, Alexandra Winkeler, Michael Schäfers, Sven Hermann, Michael T. Kuhlmann, Cornelius Faber, Andreas Faust, Stefan Wagner, Katrin Schwegmann, Lisa Honold, Sonja Schelhaas, Inga B. Fricke, Lydia Wachsmuth, Thomas Viel, Benoit Thézé, Hayet Pigeon, Bastian Zinnhardt

(A) An elliptical VOI (yellow) was drawn in the striatum. (B) Another elliptical VOI (green) was placed over the affected hemisphere. (C) After application of a thresholding based on the control VOI. The same original VOIs (left and middle) were used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2777e1bbef7baae06da639c6fe614b
https://doi.org/10.1158/0008-5472.22417409

Evaluation of 18F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue

Autor: Michael Green, Marie-Claude Asselin, Inga B. Fricke, Marco Mottinelli, Andreas H. Jacobs, Christopher R. McCurdy, Hervé Boutin, Andrew C Robinson, Michael Kassiou, David M. A. Mann, Samuel D. Banister, Matthias Vandesquille, Elizabeth Barnett, Christophe Mesangeau, Christian Prenant, Francois-Xavier Lepelletier

Publikováno v: Theranostics
Lepelletier, F-X, Vandesquille, M, Asselin, M-C, Prenant, C, Robinson, A, Mann, D, Green, M, Barnett, E, Banister, S D, Mottinelli, M, Mesangeau, C, McCurdy, C R, Fricke, I, Jacobs, A H, Kassiou, M & Boutin, H 2020, ' Evaluation of 18F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue ', Theranostics, pp. 7938-7955 . https://doi.org/10.7150/thno.47585
Lepelletier, F-X, Vandesquille, M, Asselin, M-C, Prenant, C, Robinson, A C, Mann, D M A, Green, M, Barnett, E, Banister, S D, Mottinelli, M, Mesangeau, C, McCurdy, C R, Fricke, I B, Jacobs, A H, Kassiou, M & Boutin, H 2020, ' Evaluation of F-18-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue ', Theranostics, vol. 10, no. 18, pp. 7938-7955 . https://doi.org/10.7150/thno.47585

The sigma 1 receptor (S1R) is widely expressed in the CNS and is mainly located on the endoplasmic reticulum. The S1R is involved in the regulation of many neurotransmission systems and, indirectly, in neurodegenerative diseases. The S1R may therefor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b66b6d22f18230f2146945e0b49917
https://doi.org/10.7150/thno.47585