Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Ing-Jun Chen"'
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 32, Iss 12, Pp 607-613 (2016)
We have demonstrated that KMUP-1 (7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) blunts monocrotaline-induced pulmonary arterial hypertension by altering Ca2+ sensitivity, K+-channel function, endothelial nitric oxide synthase acti
Externí odkaz:
https://doaj.org/article/0438741bf6dc45eda66b6b236904e4bc
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 32, Iss 2, Pp 55-67 (2016)
KMUP-3 (7-{2-[4-(4-nitrobenzene) piperazinyl]ethyl}-1, 3-dimethylxanthine) displays cardioprotection and increases cardiac output, and is suggested to increase cardiac performance and improve myocardial infarction. To determine whether KMUP-3 improve
Externí odkaz:
https://doaj.org/article/5826019ccdbc408a98c460af869e34ab
Autor:
Kung-Kai Kuo, Bin-Nan Wu, Chung-Pin Liu, Tzu-Yang Yang, Li-Pin Kao, Jiunn-Ren Wu, Wen-Ter Lai, Ing-Jun Chen
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2070-2084 (2015)
The phosphodiesterase inhibitor (PDEI)/eNOS enhancer KMUP-1, targeting G-protein coupled receptors (GPCRs), improves dyslipidemia. We compared its lipid-lowering effects with simvastatin and explored hormone-sensitive lipase (HSL) translocation in he
Externí odkaz:
https://doaj.org/article/5f6e602ec203408b9a39e18c4690ac5f
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 10435-10449 (2015)
The signaling cascades of the mitogen activated protein kinase (MAPK) family, calcineurin/NFATc4, and PI3K/Akt/GSK3, are believed to participate in endothelin-1 (ET-1)-induced cardiac hypertrophy. The aim of this study was to investigate whether KMUP
Externí odkaz:
https://doaj.org/article/4316c01349014302a182e2173a271f4e
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 31, Iss 5, Pp 241-254 (2015)
Ascorbic acid bound to KMUP-1 and sildenafil were examined for their antioxidant effects on vascular endothelium growth factor (VEGF) and endothelium nitric oxide synthase (eNOS) in hypoxic pulmonary artery (PA). Inhaled KMUP-1 and oral sildenafil re
Externí odkaz:
https://doaj.org/article/bda08f84fc2a43989507964cc9da25bb
Autor:
Chung-Pin Liu, Zen-Kong Dai, Chein-Heng Huang, Jwu-Lai Yeh, Bin-Nan Wu, Jiunn-Ren Wu, Ing-Jun Chen
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 30, Iss 6, Pp 267-278 (2014)
This study investigates whether endothelin-1 (ET-1) mediates monocrotaline (MCT)-induced pulmonary artery hypertension (PAH) and right ventricular hypertrophy (RVH), and if so, whether the G-protein coupled receptor antagonist KMUP-1 (7-{2-[4-(2-chlo
Externí odkaz:
https://doaj.org/article/5d1a2db06be941da943fb906c2540c3d
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 30, Iss 3, Pp 116-124 (2014)
Eugenosedin-A (Eu-A) effects on vascular endothelial dysfunction and oxidative stress in a hyperlipidemic rat model were investigated. Rats were randomly divided into four groups: two control groups and two treatment groups. The control rats received
Externí odkaz:
https://doaj.org/article/a8bc53fb3c204846b30c3e1c37464091
Autor:
Jwu-Lai Yeh, Chung-Pin Liu, Jong-Hau Hsu, Ching-Jiunn Tseng, Ping-Ju Wu, Yi-Ya Wang, Jiunn-Ren Wu, Ing-Jun Chen
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 28, Iss 11, Pp 567-576 (2012)
Hypertension can induce left ventricular hypertrophy (LVH), and the nitric oxide (NO) pathway plays an important role in the pathogenesis of cardiac hypertrophy. This study aimed to examine whether KMUP-1, a novel xanthine-based derivative, could inh
Externí odkaz:
https://doaj.org/article/c5ddc6882dc54f78bddb4c0e6a192f04
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 27, Iss 12, Pp 538-543 (2011)
This study investigated whether KMUP-1, a xanthine-based derivative, inhibits L-type Ca2+ currents (ICa,L) in rat basilar artery smooth muscle cells (RBASMCs). We used whole cell patch-clamp recording to monitor Ba2+ currents (IBa) through L-type Ca2
Externí odkaz:
https://doaj.org/article/1a3a3942ee174b0e8eb05015e4f347aa
Autor:
Jiunn-Ren Wu, Shu-Fen Liou, Shin-Wha Lin, Chee-Yin Chai, Zen-Kong Dai, Jyh-Chong Liang, Ing-Jun Chen, Jwu-Lai Yeh
Publikováno v:
Российский кардиологический журнал, Vol 0, Iss 5, Pp 41-51 (2010)
Lercanidipine, a calcium channel antagonist, is currently employed in the treatment of essential hypertension and angina pectoris. The purpose of this study was to elucidate the anti-proliferative effect of lercanidipine and to investigate the molecu
Externí odkaz:
https://doaj.org/article/95b33e42788248c3b877adb65f589d87