Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features – a retrospective analysis of the HIT ependymoma trial cohort

Autor: André O. von Bueren, Martin Mynarek, Stefan Rutkowski, Ludger Klein-Hitpass, Inken Wohlers, Torsten Pietsch, Stephanie T Jünger, Sven Rahmann, Beate Timmermann, Natalia Velez-Char, Monika Warmuth-Metz, Katja von Hoff, Rolf-Dieter Kortmann, Evelyn Dörner, Anja zur Mühlen

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)
Acta Neuropathologica Communications
Acta neuropathologica communications, Vol. 7, No 1 (2019) P. 181

Introduction Risk stratification of children with ependymomas of the posterior fossa in current therapeutic protocols is mainly based on clinical criteria. We aimed to identify independent outcome predictors for this disease entity by a systematic in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af76a756fc70196b913cc6a2c917e0a
http://link.springer.com/article/10.1186/s40478-019-0820-5

Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma

Autor: Manfred Westphal, Markus Glatzel, Carsten Friedrich, Christian Bernreuther, Ronald Simon, André O. von Bueren, Diego Sepulveda-Falla, Larissa Kolevatova, Leander van den Boom, Tobias Grob

Publikováno v: Child's Nervous System, Vol. 32, No 2 (2016) pp. 281-90

The aim of this study was to investigate the epidermal growth factor receptor (EGFR) status in ependymoma specimens, as there is a need for new prognostic and druggable targets in this disease. Ependymomas (WHO grade II, n = 40; WHO grade III, n = 15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e736afa605a01f39bd79d97ee80b35
https://pubmed.ncbi.nlm.nih.gov/26686534