Modulation of inflammation by treatment with tocilizumab after out-of-hospital cardiac arrest and associations with clinical status, myocardial- and brain injury

Autor: Martin Abild Stengaard Meyer, Mette Bjerre, Sebastian Wiberg, Johannes Grand, Laust Emil Roelsgaard Obling, Anna Sina Pettersson Meyer, Jakob Josiassen, Martin Frydland, Jakob Hartvig Thomsen, Ruth Frikke-Schmidt, Jesper Kjaergaard, Christian Hassager

Publikováno v: Meyer, M A S, Bjerre, M, Wiberg, S, Grand, J, Obling, L E R, Meyer, A S P, Josiassen, J, Frydland, M, Thomsen, J H, Frikke-Schmidt, R, Kjaergaard, J & Hassager, C 2023, ' Modulation of inflammation by treatment with tocilizumab after out-of-hospital cardiac arrest and associations with clinical status, myocardial-and brain injury ', Resuscitation, vol. 184, 109676 . https://doi.org/10.1016/j.resuscitation.2022.109676
Abild Stengaard Meyer, M, Bjerre, M, Wiberg, S, Grand, J, Emil Roelsgaard Obling, L, Sina Pettersson Meyer, A, Josiassen, J, Frydland, M, Hartvig Thomsen, J, Frikke-Schmidt, R, Kjaergaard, J & Hassager, C 2023, ' Modulation of inflammation by treatment with tocilizumab after out-of-hospital cardiac arrest and associations with clinical status, myocardial-and brain injury ', Resuscitation, vol. 184, 109676 . https://doi.org/10.1016/j.resuscitation.2022.109676

Aim: To investigate how the inflammatory response after out-of-hospital cardiac arrest (OHCA) is modulated by blocking IL-6-mediated signalling with tocilizumab, and to relate induced changes to clinical status, myocardial- and brain injury. Methods:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a14cdc5c535e007b55e3599dc852155
https://curis.ku.dk/portal/da/publications/modulation-of-inflammation-by-treatment-with-tocilizumab-after-outofhospital-cardiac-arrest-and-associations-with-clinical-status-myocardial-and-brain-injury(742a522b-4500-4683-a32f-b07b50b27480).html

Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue

Autor: Van Du T. Tran, Gabriela Aguileta, Béatrice Desvergne, Aurélien Thomas, Nasim Bararpour, Carine Winkler, Anne Wilson, Nicolas Guex, Greta Maria Paola Giordano Attianese, Marco Pagni, Federica Gilardi, Khanh B. Trang, Tiziana Caputo

Publikováno v: Cellular and molecular life sciences, vol. 78, no. 1, pp. 227-247
Cellular and Molecular Life Sciences

Chronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-associated co-morbidities. However, the molecular mechanisms initiating this inflammation in WAT are poo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d560e66d0cd72ae04098a74c1047d7bf
https://doi.org/10.1007/s00018-020-03485-z

HO-1 mitigates acute kidney injury and subsequent kidney-lung cross-talk

Autor: Maxime Rossi, Jean-Michel Hougardy, Oberdan Leo, Sandrine Delbauve, Thierry Roumeguere, Eric Wespes, Véronique Flamand, Alain Le Moine

Publikováno v: Free radical research, 53 (9-10

Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). IRI-induced AKI releases proinflammatory cytokines (e.g. IL-1β, TNF-α, IL-6) that induce a syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be4121bfcdfc537082305204dbd0625
https://doi.org/10.1080/10715762.2019.1668936

SARS-CoV-2-related MIS-C:A key to the viral and genetic causes of Kawasaki disease?

Autor: Sancho-Shimizu, Vanessa, Brodin, Petter, Cobat, Aurélie, Biggs, Catherine M., Toubiana, Julie, Lucas, Carrie L., Henrickson, Sarah E., Belot, Alexandre, Haddad, Elie, Beland, Kathie, Pujol, Aurora, Schlüter, Agatha, Planas-Serra, Laura, Aguilera-Albesa, Sergio, Valencia-Ramos, Juan, Rodríguez-Palmero, Agustí, Gut, Marta, Rivière, Jacques G., Colobran, Roger, Soler-Palacin, Pere, Rodriguez-Gallego, Carlos, Perez De Diego, Rebeca, Flores, Carlos, Alsina, Laia, Blazquez-Gamero, Daniel, Jordan, Iolanda, Keles, Sevgi, Emiroglu, Melike, Akcan, Ozge Metin, Alkan, Gulsum, Aytekin, Selma Erol, Gul, Yahya, Tüter Öz, Şadiye Kübra, Bozdemir, Sefika Elmas, Bayhan, Gulsum Iclal, Yüksek, Saliha Kanık, Parlakay, Aslınur Özkaya, Gülhan, Belgin, Yahşi, Aysun, Kilic, Ahmet Osman, Karbuz, Adem, Erdeniz, Emine Hafize, Özkan, Esra Akyüz, Orbak, Zerrin, Aydemir, Şehnaz, Celik, Jale Bengi, Kandemir, Bahar, Aytekin, Gökhan, Kapakli, Hasan, Yarar, Volkan, Yosunkaya, Alper, Vatansev, Hulya, Aytekin, Caner, Torun, Selda Hancerli, Nepesov, Serdar, Coskuner, Taner, Sözeri, Betül, Demirkol, Yasemin Kendir, Kasapcopur, Ozgur, Yıldız, Mehmet, Sevketoglu, Esra, Hatipoğlu, Nevin, Özçelik, Tayfun, Yesilbas, Osman, Gayretli Aydin, Zeynep Gökçe, Sediva, Anna, Klocperk, Adam, Bloomfield, Marketa, Meyts, Isabelle, Delafontaine, Selket, Haerynck, Filomeen, Hoste, Levi, Shahrooei, Mohammad, Marque, Laura, Neves, João Farela, Novelli, Giuseppe, Novelli, Antonio, Aiuti, Alessandro, Casari, Giorgio, Bousfiha, Amed Aziz, Almuhsen, Saleh Zaid, Sobh, Ali, Gagro, Alenka, Bajolle, Fanny, Bonnet, Damien, Lebon, Pierre, Lei, Weite, Lee, Danyel, Seeleuthner, Yoann, Zhang, Peng, Maglorius, Majistor, Philippot, Quentin, Pelham, Simon, Bastard, Paul, Zhang, Qian, Jouanguy, Emmanuelle, Puel, Anne, Herberg, Jethro, Kuijpers, Taco W, Bellos, Evangelos, Kaforou, Myrsini, Menikou, Stephanie, Pan-Hammarström, Qiang, Hammarström, Lennart, Abolhassani, Hassan, Bryceson, Yenan, Condino-Neto, Antonio, Prando, Carolina, Bando, Silvia Yumi, Cavalcanti, Andre, Fellay, Jacques, Blanchard-Hohner, Giradine, Mansouri, Davood, Mahmoudi, Shima, Boyarchuk, Oksana, Volokha, Alla, Bondarenko, Anastasiia, Stepanovskiy, Yuriy, Mogensen, Trine, van de Beek, Diederik, Andreakos, Evangelos, Papadaki, Maria, Abou Tayoun, Ahmad, Halwani, Rabih, Al-Mulla, Fahd, Franco, José Luis, Lau, Yu-Lung, Kwan, Mike, Imai, Kohsuke, Okada, Satoshi, Bolze, Alexandre, Butte, Manish J., Hsieh, Elena, Drolet, Beth A, Arkin, Lisa, Itan, Yuval, Maniatis, Tom, Arditi, Moshe, Cooper, Megan, Schmitt, Erica, Chakravorty, Samya, Anderson, Mark S., Su, Helen C., Notarangelo, Luigi D., MIS-C@CHGE, [missing], Tangye, Stuart G., Milner, Joshua D., Levin, Michael, Abel, Laurent, Bogunovic, Dusan, Casanova, Jean-Laurent, Zhang, Shen-Ying

Publikováno v: Sancho-Shimizu, V, Brodin, P, Cobat, A, Biggs, C M, Toubiana, J, Lucas, C L, Henrickson, S E, Belot, A, Tangye, S G, Milner, J D, Levin, M, Abel, L, Bogunovic, D, Casanova, J L, Zhang, S Y & MIS-CCHGE 2021, ' SARS-CoV-2-related MIS-C : A key to the viral and genetic causes of Kawasaki disease? ', Journal of Experimental Medicine, vol. 218, no. 6, e20210446 . https://doi.org/10.1084/jem.20210446
The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, 2021, 218 (6), ⟨10.1084/jem.20210446⟩
JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2 is the trigger of MIS-C, which suggests that other viruses may trigger different forms of Kawasaki disease. The discovery of inborn errors of immunity underlying MIS-C would facilitate that of inborn errors of immunity to viruses underlyin

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https://pure.au.dk/portal/da/publications/sarscov2related-misc(78e24f0b-630f-4730-bc8e-6ca40354d18d).html

Longitudinal Analysis of Inflammatory Response to SARS-CoV-2 in the Upper Respiratory Tract Reveals an Association With Viral Load, Independent of Symptoms

Autor: Diem-Lan Vu, Christiane S. Eberhardt, Benjamin Meyer, Claire-Anne Siegrist, Elodie von Dach, Sylvain Lemeille, Angela Huttner, Laurent Kaiser, Fiona Pigny, Arnaud M. Didierlaurent, Isabella Eckerle, Maria Vono, Paola Martinez-Murillo, Geraldine Blanchard-Rohner

Publikováno v: Journal of clinical immunology, Vol. 41, No 8 (2021) pp. 1723-1732
Journal of Clinical Immunology

Background SARS-CoV-2 infection leads to high viral loads in the upper respiratory tract that may be determinant in virus dissemination. The extent of intranasal antiviral response in relation to symptoms is unknown. Understanding how local innate re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8fc999b67a57d6fac36f5bf6d49ffc
https://doi.org/10.21203/rs.3.rs-203414/v1