VEXAS Syndrome: A Call for Diagnostic Awareness Based on a Case Series of Seven Patients

Autor: Filipe R. Pinto, António Lamas, Daniel G. Oliveira, Márcia E. Oliveira, Raquel Faria

Publikováno v: Acta Médica Portuguesa (2023)

N/a.

Externí odkaz: https://doaj.org/article/1f33e427401d43a5908a454c928cf115

The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2

Autor: Tim Vierbuchen, Shiuli Agarwal, John L. Johnson, Liraz Galia, Xuqiu Lei, Karina Stein, David Olagnier, Karoline I. Gaede, Christian Herzmann, Christian K. Holm, Holger Heine, Athma Pai, Aisling O’Hara Hall, Kasper Hoebe, Katherine A. Fitzgerald

Publikováno v: Vierbuchen, T, Agarwal, S, Johnson, J L, Galia, L, Lei, X, Stein, K, Olagnier, D, Gaede, K I, Herzmann, C, Holm, C K, Heine, H, Pai, A, O'Hara Hall, A, Hoebe, K & Fitzgerald, K A 2023, ' The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 1, pp. e2213715120 . https://doi.org/10.1073/pnas.2213715120

The nuclear long non-coding RNA LUCAT1 has previously been identified as a negative feedback regulator of type I interferon and inflammatory cytokine expression in human myeloid cells. Here, we define the mechanistic basis for the suppression of infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4119871f4c6d7df23af628c24378908e
https://pubmed.ncbi.nlm.nih.gov/36577072

DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Autor: Wielscher, Matthias, Mandaviya, Pooja R, Kuehnel, Brigitte, Joehanes, Roby, Mustafa, Rima, Robinson, Oliver, Zhang, Yan, Bodinier, Barbara, Walton, Esther, Mishra, Pashupati P, Schlosser, Pascal, Wilson, Rory, Tsai, Pei-Chien, Palaniswamy, Saranya, Marioni, Riccardo E, Fiorito, Giovanni, Cugliari, Giovanni, Karhunen, Ville, Ghanbari, Mohsen, Psaty, Bruce M, Loh, Marie, Bis, Joshua C, Lehne, Benjamin, Sotoodehnia, Nona, Deary, Ian J, Chadeau-Hyam, Marc, Brody, Jennifer A, Cardona, Alexia, Selvin, Elizabeth, Smith, Alicia K, Miller, Andrew H, Torres, Mylin A, Marouli, Eirini, Gào, Xin, Van Meurs, Joyce BJ, Graf-Schindler, Johanna, Rathmann, Wolfgang, Koenig, Wolfgang, Peters, Annette, Weninger, Wolfgang, Farlik, Matthias, Zhang, Tao, Chen, Wei, Xia, Yujing, Teumer, Alexander, Nauck, Matthias, Grabe, Hans J, Doerr, Macus, Lehtimäki, Terho, Guan, Weihua, Milani, Lili, Tanaka, Toshiko, Fisher, Krista, Waite, Lindsay L, Kasela, Silva, Vineis, Paolo, Verweij, Niek, Van Der Harst, Pim, Iacoviello, Licia, Sacerdote, Carlotta, Panico, Salvatore, Krogh, Vittorio, Tumino, Rosario, Tzala, Evangelia, Matullo, Giuseppe, Hurme, Mikko A, Raitakari, Olli T, Colicino, Elena, Baccarelli, Andrea A, Kähönen, Mika, Herzig, Karl-Heinz, Li, Shengxu, BIOS Consortium, Conneely, Karen N, Kooner, Jaspal S, Köttgen, Anna, Heijmans, Bastiaan T, Deloukas, Panos, Relton, Caroline, Ong, Ken K, Bell, Jordana T, Boerwinkle, Eric, Elliott, Paul, Brenner, Hermann, Beekman, Marian, Levy, Daniel, Waldenberger, Melanie, Chambers, John C, Dehghan, Abbas, Järvelin, Marjo-Riitta

Publikováno v: Nature Communications, 13(1). NATURE PORTFOLIO
Nat. Commun. 13:2408 (2022)
Nature Communications, 13:2408. Nature Publishing Group
Nature Communications
Nature Communications, 13(1):2408. Nature Publishing Group
Wielscher, M, Mandaviya, P R, Kuehnel, B, Joehanes, R, Mustafa, R, Robinson, O, Zhang, Y, Bodinier, B, Walton, E, Mishra, P P, Schlosser, P, Wilson, R, Tsai, P-C, Palaniswamy, S, Marioni, R E, Fiorito, G, Cugliari, G, Karhunen, V, Ghanbari, M, Psaty, B M, Loh, M, Bis, J C, Lehne, B, Sotoodehnia, N, Deary, I J, Chadeau-Hyam, M, Brody, J A, Cardona, A, Selvin, E, Smith, A K, Miller, A H, Torres, M A, Marouli, E, Gào, X, van Meurs, J B J, Graf-Schindler, J, Rathmann, W, Koenig, W, Peters, A, Weninger, W, Farlik, M, Zhang, T, Chen, W, Xia, Y, Teumer, A, Nauck, M, Grabe, H J, Doerr, M, Lehtimäki, T, Guan, W, Milani, L, Tanaka, T, Fisher, K, Waite, L L, Kasela, S, Vineis, P, Verweij, N, van der Harst, P, Iacoviello, L, Sacerdote, C, Panico, S, Krogh, V, Tumino, R, Tzala, E, Matullo, G, Hurme, M A, Raitakari, O T, Colicino, E, Baccarelli, A A, Kähönen, M, Herzig, K-H, Li, S, Conneely, K N, Kooner, J S, Köttgen, A, Heijmans, B T, Deloukas, P, Relton, C, Ong, K K, Bell, J T, Boerwinkle, E, Elliott, P, Brenner, H, Beekman, M, Levy, D, Waldenberger, M, Chambers, J C, Dehghan, A & Järvelin, M-R 2022, ' DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases ', Nature Communications, vol. 13, 2408 . https://doi.org/10.1038/s41467-022-29792-6

Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive protein levels and find t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf8cc1ac792293a388782a2252ded72
https://doi.org/10.1038/s41467-022-29792-6

Genetic analysis of over half a million people characterises C-reactive protein loci

Autor: Saredo Said, Raha Pazoki, Ville Karhunen, Urmo Võsa, Symen Ligthart, Barbara Bodinier, Fotios Koskeridis, Paul Welsh, Behrooz Z. Alizadeh, Daniel I. Chasman, Naveed Sattar, Marc Chadeau-Hyam, Evangelos Evangelou, Marjo-Riitta Jarvelin, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan

Publikováno v: Nature communications
Nature Communications, 13(1):2198. Nature Publishing Group

Data availability: The summary statistics of the CHARGE CRP GWAS used in this study is publicly available from the IEU open GWAS project accession code ieu-b-35 (Trait: C-Reactive protein level - IEU Open GWAS project (mrcieu.ac.uk)). The derived CRP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717c65319920c0aaba1c7586672585a2
http://hdl.handle.net/10044/1/96684

Dietary tryptophan deficiency and its supplementation compromises inflammatory mechanisms and disease resistance in a teleost fish

Autor: Luís E.C. Conceição, Sergio Fernández-Boo, Rita Azeredo, Jorge Dias, Benjamín Costas, Marina Machado, A. Domingues

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports

Tryptophan participates on several physiological mechanisms of the neuroendocrine-immune network and plays a critical role in macrophages and lymphocytes function. This study intended to evaluate the modulatory effects of dietary tryptophan on the Eu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1034b2c1543a2a27320594b17ece3f
http://link.springer.com/article/10.1038/s41598-019-44205-3