Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Inflammasomes/drug effects"'
Autor:
Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm
Publikováno v:
Østergaard, J A, Jha, J C, Sharma, A, Dai, A, Choi, J S Y, De Haan, J B, Cooper, M E & Jandeleit-Dah, K 2022, ' Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease ', Clinical Science, vol. 136, no. 2, pp. 167-180 . https://doi.org/10.1042/CS20210865
Clinical Science (London, England : 1979)
Clinical Science (London, England : 1979)
Activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome has been reported in diabetic complications including diabetic kidney disease (DKD). However, it remains unknown if NLRP3 inhibition
Publikováno v:
Scientific Reports
Scientific reports, vol. 7, pp. 43844
Scientific reports, vol. 7, pp. 43844
The inflammasome–IL-1 axis and type I interferons (IFNs) have been shown to exert protective effects upon respiratory tract infections. Conversely, IL-1 has also been implicated in inflammatory airway pathologies such as asthma and chronic obstruct
Autor:
Stephanie Zwicker, D. Bureik, Aleksandra Batycka-Baran, Thomas Ruzicka, Simon Rothenfusser, Andreas Schmidt, Ronald Wolf, Michel Gilliet, Eva Hattinger, Peter-Arne Gerber
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175153 (2017)
PloS one, vol. 12, no. 4, pp. e0175153
PLoS ONE
PloS one, vol. 12, no. 4, pp. e0175153
PLoS ONE
IL-1β is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis. Its production is controlled at the transcriptional level and by subsequent posttranslational
Autor:
François Trottein, Adam P Uldrich, Thierry Mallevaey, Christophe Paget, Paul J Neeson, Dale I. Godfrey, Geoffrey R. Hill, N. A. Gherardin, Paul A. Beavis, David Dombrowicz, Delphine Staumont-Sallé, Maya Hassane, Denis A. Mogilenko, N. K. Escalante, Mark J. Smyth, Fernando Souza-Fonseca-Guimaraes, Melvyn T. Chow, Helene Duret, David Ritchie, Gabrielle T. Belz
Publikováno v:
Immunology and Cell Biology
Immunology and Cell Biology, 2015, 93 (2), pp.198-212. ⟨10.1038/icb.2014.94⟩
Immunology and Cell Biology, Nature Publishing Group, 2015, 93 (2), pp.198-212. ⟨10.1038/icb.2014.94⟩
Immunology and Cell Biology, 2015, 93 (2), pp.198-212. ⟨10.1038/icb.2014.94⟩
Immunology and Cell Biology, Nature Publishing Group, 2015, 93 (2), pp.198-212. ⟨10.1038/icb.2014.94⟩
International audience; Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has an important role at mucosal sites in a wide range of immune responses including infection, allergy and auto-immunity. γδ T cells are recognized as IL-17 produ
Publikováno v:
PLoS One, vol. 6, no. 5, pp. e19588
PLoS ONE
PLoS ONE, Vol 6, Iss 5, p e19588 (2011)
PLoS ONE
PLoS ONE, Vol 6, Iss 5, p e19588 (2011)
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocyt
Autor:
Bojan Bujisic, Léa Zaffalon, Manfredo Quadroni, Gianluca Frera, Fabio Martinon, Aubry Tardivel, Aude De Gassart, Jérôme Lugrin, Yvan Jamilloux, Stefanie Siegert, Thomas Henry, Petr Broz, Erh-Ting Hsu, Antonia Di Micco, Christine A. Hrycyna
Publikováno v:
Proceedings of the National Acadamy of Science
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (32), pp.E4671-4680. ⟨10.1073/pnas.1602419113⟩
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (32), pp.E4671-4680. ⟨10.1073/pnas.1602419113⟩
Europe PubMed Central
Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 32, pp. E4671-80
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (32), pp.E4671-4680. ⟨10.1073/pnas.1602419113⟩
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (32), pp.E4671-4680. ⟨10.1073/pnas.1602419113⟩
Europe PubMed Central
Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 32, pp. E4671-80
International audience; Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the immune system by activating inflammatory caspases and cytokines such as IL-1β. The nature of endogenous stress signals that activate