Zobrazeno 1 - 10
of 495
pro vyhledávání: '"Infectious Diseases/Protozoal Infections"'
Autor:
Walker, RG, Thomson, G, Malone, K, Nowicki, MW, Brown, E, Blake, DG, Turner, NJ, Walkinshaw, MD, Grant, KM, Mottram, JC, Kita, K
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 4, p e1033 (2011)
PLoS Neglected Tropical Diseases
Walker, R G, Thomson, G, Malone, K, Nowicki, M W, Brown, E, Blake, D G, Turner, N J, Walkinshaw, M D, Grant, K M & Mottram, J C 2011, ' High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase ', PLoS Neglected Tropical Diseases, vol. 5, no. 4, e1033, pp.-. https://doi.org/10.1371/journal.pntd.0001033
PLoS Neglected Tropical Diseases
Walker, R G, Thomson, G, Malone, K, Nowicki, M W, Brown, E, Blake, D G, Turner, N J, Walkinshaw, M D, Grant, K M & Mottram, J C 2011, ' High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase ', PLoS Neglected Tropical Diseases, vol. 5, no. 4, e1033, pp.-. https://doi.org/10.1371/journal.pntd.0001033
Background Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4a59d8a81dce37c29a9e8c905839f0
https://ora.ox.ac.uk/objects/uuid:b7ac0f17-98da-41fb-a2d5-8f53ae85b653
https://ora.ox.ac.uk/objects/uuid:b7ac0f17-98da-41fb-a2d5-8f53ae85b653
Autor:
Makie Taal, David J. Conway, Climent Casals-Pascual, Davis Nwakanma, Aja Adam Jagne Sonko, Kalifa Bojang, Serign J. Ceesay, Sarah I. Nogaro, Natalia Gomez-Escobar, Tumani Corrah, Ebako N. Takem, Michael Walther, Momodou Cherno Jaye, Anthony J. C. Fulford
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12242 (2010)
PLoS ONE, Vol 5, Iss 8, p e12242 (2010)
BACKGROUND: A substantial decline in malaria was reported to have occurred over several years until 2007 in the western part of The Gambia, encouraging consideration of future elimination in this previously highly endemic region. Scale up of interven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796eb466db57b911ddf68e960851cc1d
https://ora.ox.ac.uk/objects/uuid:4ed14527-6bbb-4f21-878e-4f93542cd4ba
https://ora.ox.ac.uk/objects/uuid:4ed14527-6bbb-4f21-878e-4f93542cd4ba
Autor:
Bui H. Manh, Rosalind E. Howes, Andrew J. Tatem, Thomas P. Van Boeckel, William H. Temperley, Anand P. Patil, J. Kevin Baird, Carlos A Guerra, Peter W. Gething, Robert W. Snow, Simon I. Hay, Iqbal R. F. Elyazar, Caroline W Kabaria
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 8, p e774 (2010)
PLoS neglected tropical diseases, 4 (8
PLoS Neglected Tropical Diseases
PLoS neglected tropical diseases, 4 (8
PLoS Neglected Tropical Diseases
Background: A research priority for Plasmodium vivax malaria is to improve our understanding of the spatial distribution of risk and its relationship with the burden of P. vivax disease in human populations. The aim of the research outlined in this a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f334da912b88c33135b8393a572b5c1f
https://doi.org/10.1371/journal.pntd.0000774
https://doi.org/10.1371/journal.pntd.0000774
Autor:
Dominic P. Kwiatkowski, Conor P. Doherty, Sarah H. Atkinson, Chidi V. Nweneka, Sharon E. Cox, Hala Ghattas, Kirk A. Rockett, Anthony J. C. Fulford, Andrew M. Prentice
Publikováno v:
PLoS ONE, Vol 2, Iss 4, p e362 (2007)
PLoS ONE
PLoS ONE
BACKGROUND: Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations-despite the increased risk of mortality in the homozygous states. Previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c1e029c9e5b3cc463754b169ff85ac
https://ora.ox.ac.uk/objects/uuid:8f132597-bd1c-4769-a594-811400ca335d
https://ora.ox.ac.uk/objects/uuid:8f132597-bd1c-4769-a594-811400ca335d
Publikováno v:
PloS Pathogens
PLOS Pathogens, Vol. 6, No 10 (2010)
PLoS Pathogens, Vol 6, Iss 10, p e1001132 (2010)
PLoS Pathogens
PLOS Pathogens, Vol. 6, No 10 (2010)
PLoS Pathogens, Vol 6, Iss 10, p e1001132 (2010)
PLoS Pathogens
The invasive forms of apicomplexan parasites share a conserved form of gliding motility that powers parasite migration across biological barriers, host cell invasion and egress from infected cells. Previous studies have established that the duration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d61054b1ded49e55a0e41e35871fede
http://www.ncbi.nlm.nih.gov/pubmed/20949068
http://www.ncbi.nlm.nih.gov/pubmed/20949068
Autor:
Renato Sathler-Avelar, Juliana A. S. Gomes, Manoel Otávio da Costa Rocha, Fernanda Fortes de Araújo, Rodrigo Correa-Oliveira, Andréa Teixeira-Carvalho, Paulo R. Z. Antas, R.T. Pinho, Danielle Marquete Vitelli-Avelar, Olindo Assis Martins-Filho, Silvana Maria Elói-Santos
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 5, Iss 5, p e992 (2011)
PLoS Neglected Tropical Diseases, Vol 5, Iss 5, p e992 (2011)
CD25(High) CD4+ regulatory T cells (Treg cells) have been described as key players in immune regulation, preventing infection-induced immune pathology and limiting collateral tissue damage caused by vigorous anti-parasite immune response. In this rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c1eed8da7fed5a8d8f217512daf8a9
https://pubmed.ncbi.nlm.nih.gov/21655351
https://pubmed.ncbi.nlm.nih.gov/21655351
Autor:
Daniel L. Hartl, Daria Van Tyne, Elaine Angelino, Kayla G. Barnes, Nicholas A. Furlotte, Bruce W. Birren, David M. B. Rosen, Dyann F. Wirth, Souleymane Mboup, Daniel L. K. Yamins, Ilya Shlyakhter, Charles A. Johnson, Rachel F. Daniels, Sarah K. Volkman, Joseph F. Cortese, Eleazar Eskin, Justin S. Becker, Sharon R. Grossman, Christian T. Happi, Elinor K. Karlsson, Daniel E. Neafsey, Daouda Ndiaye, Pardis C. Sabeti, Ousmane Sarr, Hyun Min Kang, Danny A. Milner, Eric S. Lander, Stephen F. Schaffner, Amanda K. Lukens, Daniel J. Park, Roger C. Wiegand
Publikováno v:
PLoS Genetics, Vol 7, Iss 4, p e1001383 (2011)
PLoS Genetics
PLoS genetics, vol 7, iss 4
PLoS
PLoS Genetics
PLoS genetics, vol 7, iss 4
PLoS
The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis of these adaptations is criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94d801a32f09b3c69ef6ecacbc5c0d5
http://europepmc.org/articles/PMC3080868?pdf=render
http://europepmc.org/articles/PMC3080868?pdf=render
Autor:
Tatiana M. Lopera-Mesa, Hisashi Fujioka, Nathaniel J. Brittain, Rick M. Fairhurst, Chanaki Amaratunga, Rushina Cholera, Takayuki Arie, Jeffrey R. Keefer
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e14798 (2011)
PLoS ONE
PLoS ONE
Background In Africa, infant susceptibility to Plasmodium falciparum malaria increases substantially as fetal hemoglobin (HbF) and maternal immune IgG disappear from circulation. During the first few months of life, however, resistance to malaria is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e46c76a96ccb9bd100338ecbccb42de
http://europepmc.org/articles/PMC3075246?pdf=render
http://europepmc.org/articles/PMC3075246?pdf=render
Autor:
Takeshi Hatta, Yasunobu Matsumoto, M. Abdul Alim, Takeharu Miyoshi, Anisuzzaman, Naotoshi Tsuji, Kayoko Yamaji, M. Khyrul Islam, Kozo Fujisaki
Publikováno v:
PLoS Pathogens, Vol 7, Iss 3, p e1001312 (2011)
PLoS Pathogens
PLoS Pathogens
Ixodid ticks are notorious blood-sucking ectoparasites and are completely dependent on blood-meals from hosts. In addition to the direct severe effects on health and productivity, ixodid ticks transmit various deadly diseases to humans and animals. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8943b8f94d67b049c02e7220af4fc40
http://europepmc.org/articles/PMC3053353?pdf=render
http://europepmc.org/articles/PMC3053353?pdf=render
Autor:
Agnès Hovasse, Christine Schaeffer-Reiss, Alain Van Dorsselaer, Thomas Mouveaux, Alejandro Olguin-Lamas, Stanislas Tomavo, Edwige Madec, Christian Slomianny, Elisabeth Werkmeister, Stéphane Delhaye, Isabelle Callebaut
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 7, Iss 3, p e1001328 (2011)
PLoS Pathogens, Public Library of Science, 2011, 7 (3), pp.e1001328. ⟨10.1371/journal.ppat.1001328⟩
PLoS Pathogens, 2011, 7 (3), pp.e1001328. ⟨10.1371/journal.ppat.1001328⟩
PLoS Pathogens, Vol 7, Iss 3, p e1001328 (2011)
PLoS Pathogens, Public Library of Science, 2011, 7 (3), pp.e1001328. ⟨10.1371/journal.ppat.1001328⟩
PLoS Pathogens, 2011, 7 (3), pp.e1001328. ⟨10.1371/journal.ppat.1001328⟩
In Toxoplasma gondii, cis-acting elements present in promoter sequences of genes that are stage-specifically regulated have been described. However, the nuclear factors that bind to these cis-acting elements and regulate promoter activities have not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329b799eb81cff83b5f39da58b88ce5b
http://europepmc.org/articles/PMC3068996
http://europepmc.org/articles/PMC3068996