Výsledky vyhledávání - "Infectious Diseases/Prion Diseases"

Sheep and goat BSE propagate more efficiently than cattle BSE in human PrP transgenic mice

Autor: Hubert Laude, Juan María Torres, Fabienne Reine, Laetitia Herzog, Juan Carlos Espinosa, Alfonso Gutiérrez-Adán, Emilie Jaumain, Vincent Béringue, Danielle Padilla, Belén Pintado, Olivier Andreoletti

Publikováno v: PLoS Pathogens, Vol 7, Iss 3, p e1001319 (2011)
PLoS Pathogens
Plos Pathogens 3 (7), e1001319. (2011)
Repositorio de Resultados de Investigación del INIA
INIA: Repositorio de Resultados de Investigación del INIA
PLoS Pathogens, Public Library of Science, 2011, 7 (3), pp.e1001319. ⟨10.1371/journal.ppat.1001319⟩
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA

A new variant of Creutzfeldt Jacob Disease (vCJD) was identified in humans and linked to the consumption of Bovine Spongiform Encephalopathy (BSE)-infected meat products. Recycling of ruminant tissue in meat and bone meal (MBM) has been proposed as o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f4eb89c9ebae306fc20118e09d341a
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21445238/pdf/?tool=EBI

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The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

Autor: Jacob I. Ayers, Charles R. Schutt, Anthony E. Kincaid, Jason C. Bartz, Ronald A. Shikiya, Adriano Aguzzi

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 7, Iss 3, p e1001317 (2011)

Prion strains are characterized by differences in the outcome of disease, most notably incubation period and neuropathological features. While it is established that the disease specific isoform of the prion protein, PrPSc, is an essential component

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873e574df389edc7632837c7aa00588b
http://europepmc.org/articles/PMC3060105

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Molecular interactions between prions as seeds and recombinant prion proteins as substrates resemble the biological interspecies barrier in vitro

Autor: Lars Luers, Detlev Riesner, Luitgard Nagel-Steger, Jürgen Weiβ, Jan Stöhr, Giannantonio Panza, Dieter Willbold, Eva Birkmann

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14283 (2010)
PLoS one 5, e14283 (2010). doi:10.1371/journal.pone.0014283
PLoS ONE

Prion diseases like Creutzfeldt-Jakob disease in humans, Scrapie in sheep or bovine spongiform encephalopathy are fatal neurodegenerative diseases, which can be of sporadic, genetic, or infectious origin. Prion diseases are transmissible between diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa5b084d643b58d5951596a465f87d0
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21151607/?tool=EBI

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Highly efficient protein misfolding cyclic amplification

Autor: Irina Alexeeva, Valeriy G. Ostapchenko, Regina Savtchenk, Nuria González-Montalbán, Natallia Makarava, Ilia V. Baskakov, Robert G. Rohwer

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 7, Iss 2, p e1001277 (2011)

Protein misfolding cyclic amplification (PMCA) provides faithful replication of mammalian prions in vitro and has numerous applications in prion research. However, the low efficiency of conversion of PrPC into PrPSc in PMCA limits the applicability o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ef12c81799967a140415babb76afda
https://pubmed.ncbi.nlm.nih.gov/21347353

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Glycosaminoglycan Sulphation Affects the Seeded Misfolding of a Mutant Prion Protein

Autor: David E. Hoke, Katrina Gouramanis, Steven J. Collins, Andrew F. Hill, Jeremy M. Welton, Victoria A. Lawson, Brooke Lumicisi, Colin L. Masters, Dorothy A Machalek, Helen M. J. Klemm, James D. Stewart

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12351 (2010)

BackgroundThe accumulation of protease resistant conformers of the prion protein (PrP(res)) is a key pathological feature of prion diseases. Polyanions, including RNA and glycosaminoglycans have been identified as factors that contribute to the propa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2562de4fb35c85a91dc4e7c9191dd96a
http://europepmc.org/articles/PMC2925953

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Novel quantitative real-time LCR for the sensitive detection of SNP frequencies in pooled DNA: method development, evaluation and application

Autor: Chrysostomos I. Dovas, Androniki Psifidi, Georgios Banos

Publikováno v: PLoS ONE
Psifidi, A, Dovas, C & Banos, G 2011, ' Novel Quantitative Real-Time LCR for the Sensitive Detection of SNP Frequencies in Pooled DNA: Method Development, Evaluation and Application ', PLoS ONE, vol. 6, no. 1, ARTN e14560 . https://doi.org/10.1371/journal.pone.0014560
PLoS ONE, Vol 6, Iss 1, p e14560 (2011)

Background: Single nucleotide polymorphisms (SNP) have proven to be powerful genetic markers for genetic applications in medicine, life science and agriculture. A variety of methods exist for SNP detection but few can quantify SNP frequencies when th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912c8a897022e1b83a658d6b0b0b8efc
https://pubmed.ncbi.nlm.nih.gov/21283808

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Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells

Autor: Qi Shi, Xin Wang, Cao Chen, Xiao-Ping Dong, Kun Xu, Jun Han, Chen Gao, Xiaoli Li, Gui-Rong Wang, Chan Tian

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e14602 (2011)

BackgroundGenetic prion diseases are linked to point and inserted mutations in the prion protein (PrP) gene that are presumed to favor conversion of the cellular isoform of PrP (PrP(C)) to the pathogenic one (PrP(Sc)). The pathogenic mechanisms and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ace49b42d9c9c0dba2431d14d73ae0
https://pubmed.ncbi.nlm.nih.gov/21298055

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Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays

Autor: Kimberly Meade-White, Ryuichiro Atarashi, Kazunori Sano, Christina D. Orrú, Byron Caughey, Brent Race, Andrew Timmes, Richard A. Bessen, Jason M. Wilham, Lara M. Taubner

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 6, Iss 12, p e1001217 (2010)

A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such measurements have typically required prolonged bioassays in animals. Highly sensitive, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7c0e17126eef7d218508f8f718b2a3
https://pubmed.ncbi.nlm.nih.gov/21152012

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Prion Shedding from Olfactory Neurons into Nasal Secretions

Autor: Richard A. Bessen, Diana Lowe, Ryan Boharski, Harold K. Shearin, Jason M. Wilham, Byron Caughey, James Wiley, Scott Martinka

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 6, Iss 4, p e1000837 (2010)

This study investigated the role of prion infection of the olfactory mucosa in the shedding of prion infectivity into nasal secretions. Prion infection with the HY strain of the transmissible mink encephalopathy (TME) agent resulted in a prominent in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ba2e93d6d7756b6b25d61b00554324
http://europepmc.org/articles/PMC2855443

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A camelid anti-PrP antibody abrogates PrP replication in prion-permissive neuroblastoma cell lines

Autor: Monique David, Mourad Tayebi, William Alexander Taylor, Daryl R. Jones, Clive Bate

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9804 (2010)
PLoS ONE

The development of antibodies effective in crossing the blood brain barrier (BBB), capable of accessing the cytosol of affected cells and with higher affinity for PrP(Sc) would be of paramount importance in arresting disease progression in its late s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d199190547da7ebc4fed43ab777435fb
http://europepmc.org/articles/PMC2842437?pdf=render

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