Clinical Implications of Minimal Residual Disease Detection in Infants With KMT2A-Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Autor: Tomasz Szczepański, Claus Meyer, Maria Grazia Valsecchi, Jan Stary, Birgitte Lausen, Alina Ferster, Gabriele Escherich, Inge M. van der Sluis, Martin Schrappe, Myriam Campbell, Vincent H.J. van der Velden, Giovanni Cazzaniga, Rishi S. Kotecha, Luca Lo Nigro, Julia Alten, Andishe Attarbaschi, Franco Locatelli, Andrea Biondi, Ajay Vora, Rolf Marschalek, Chi Kong Li, Jan Zuna, Benoit Brethon, Rob Pieters, Paola De Lorenzo, Philip Ancliffe, Janine Stutterheim

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(6), 652-662. American Society of Clinical Oncology

PURPOSE Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of KMT2A gene rearrangements and poor outcome. We evaluated the value of minimal residual disease (MRD) in infants with KMT2A-rearranged ALL treated within the Int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6e805aa4f36865f5de5258990e88b0
http://www.scopus.com/inward/record.url?scp=85102211952&partnerID=8YFLogxK

Combinatorial efficacy of entospletinib and chemotherapy in patient-derived xenograft models of infant acute lymphoblastic leukemia

Autor: Min Wang, Joseph P. Loftus, Lisa M Niswander, Stacey Tannheimer, Patrick A. Brown, Anella Yahiaoui, Sarah K. Tasian, Asen Bagashev, Allyson Schauf

Publikováno v: Haematologica

Survival of infants with KMT2A-rearranged acute lymphoblastic leukemia (ALL) remains dismal despite intensive chemotherapy. We observed constitutive phosphorylation of spleen tyrosine kinase (SYK) and associated signaling proteins in infant ALL patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74395599a840c456d0bbee25719b9029
http://europepmc.org/articles/PMC8018117

Efficacy of combined CDK9/BET inhibition in preclinical models of MLL-rearranged acute leukemia

Autor: John Toubia, Hannah McCalmont, Debora A. Casolari, Chelsea Mayoh, Saumya E. Samaraweera, Richard J D'Andrea, Sarah C Bray, Ka Leung Li, Ian D. Lewis, Rab K. Prinjha, Nicholas Smithers, Luke Jones, Shudong Wang, Richard B. Lock

Publikováno v: Blood Advances. 4:296-300

Chromosomal rearrangements of the lysine methyltransferase 2A (KMT2A or MLL) gene are observed in ;10% of all acute leukemias, with particularly high frequency (;80%) in infant acute lymphoblastic leukemia (ALL),1 where, despite aggressive chemothera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac76a42f5d50145a4ad43bba4449e8e2
https://doi.org/10.1182/bloodadvances.2019000586

Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia

Autor: Jette Ford, Sébastien Malinge, Joyce Oommen, Sajla Singh, Anastasia M. Hughes, Emanuela Ferrari, Grace-Alyssa Chua, Mark N. Cruickshank, Rishi S. Kotecha, Laurence C. Cheung, Ursula R. Kees, Richard B. Lock

Publikováno v: Haematologica. 104:e300-e303

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d1cdfb9054505856971b3105a150375
https://doi.org/10.3324/haematol.2018.192906

FLT3 inhibitor lestaurtinib plus chemotherapy for newly diagnosed KMT2A-rearranged infant acute lymphoblastic leukemia: Children’s Oncology Group trial AALL0631

Autor: Joanne M. Hilden, Mignon L. Loh, Stephen P. Hunger, Lia Gore, Elizabeth A. Raetz, Naomi J. Winick, William L. Carroll, Donald Small, John A. Kairalla, Cindy Wang, Wanda L. Salzer, Nyla A. Heerema, Zo Ann E. Dreyer, Meenakshi Devidas, Michael J. Borowitz, Andrew J. Carroll, Patrick A. Brown

Publikováno v: Leukemia

Infants with KMT2A‐rearranged acute lymphoblastic leukemia (KMT2A-r ALL) have a poor prognosis. KMT2A-r ALL overexpresses FLT3, and the FLT3 inhibitor (FLT3i) lestaurtinib potentiates chemotherapy‐induced cytotoxicity in preclinical models. Child

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936bfdc962c0b2ff7a0463ffafe7612c
https://europepmc.org/articles/PMC8763141/